Critical roles of non-histone protein lysine methylation in human tumorigenesis

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Items 101–200 of 387

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2. The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck
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3. Substrate and Functional Diversity of Protein Lysine Post-translational Modifications
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4. Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites
   Patty B. Chen, Shuai Dominique Ding, Gigliola Zanghì, Valérie Soulard, Peter A. DiMaggio, Matthew John Fuchter, Salaheddine Mécheri, Dominique Mazier, Artur Scherf, Nicholas A. Malmquist · 2016 · Scientific Reports
5. Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells
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6. Protein lysine methyltransferase SMYD 3 is involved in tumorigenesis through regulation of HER 2 homodimerization
   Yuichiro Yoshioka, Takehiro Suzuki, Yo Matsuo, Giichiro Tsurita, Toshiaki Watanabe, Naoshi Dohmae, Yusuke Nakamura, Ryuji Hamamoto · 2017 · Cancer Medicine
7. BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation
   Zlata Vershinin, Michal Feldman, Thilo Werner, Lital Estrella Weil, Margarita Kublanovsky, Elina Abaev-Schneiderman, Menachem Y. Sklarz, Enid Y.N. Lam, Khawla Alasad, S. Picaud et al. · 2021 · Science Advances
8. Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila
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9. Repressing the repressor: Ezh2 mediates macrophage activation
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10. Histone methyl transferases: A class of epigenetic opportunities to counter uncontrolled cell proliferation
    Pankaj Kumar Singh · 2019 · European Journal of Medicinal Chemistry
11. SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck
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12. PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP
    Xiaolan Deng, Gottfried von Keudell, Takehiro Suzuki, Naoshi Dohmae, Makoto Nakakido, Lianhua Piao, Yuichiro Yoshioka, Yusuke Nakamura, Ryuji Hamamoto · 2015 · Oncotarget
13. GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1
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14. Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors
    Scott D. Cowen, Daniel John Russell, Leslie A. Dakin, Huawei Chen, Nicholas Larsen, Robert E. Godin, Scott R. Throner, Xiaolan Zheng, Audrey Molina, Jiaquan Wu et al. · 2016 · Journal of Medicinal Chemistry
15. Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis
    Chayanid Ongpipattanakul, Satish K. Nair · 2018 · ACS Chemical Biology
16. Inhibition of SMYD2 Sensitized Cisplatin to Resistant Cells in NSCLC Through Activating p53 Pathway
    Lei Shang, Minjie Wei · 2019 · Frontiers in Oncology
17. iLM-2L: A two-level predictor for identifying protein lysine methylation sites and their methylation degrees by incorporating K-gap amino acid pairs into Chou׳s general PseAAC
    Zhe Ju, Jun-Zhe Cao, Hong Gu · 2015 · Journal of Theoretical Biology
18. SETDB1 acts as a topological accessory to Cohesin via an H3K9me3-independent, genomic shunt for regulating cell fates
    Tushar Warrier, Chadi A. El Farran, Yingying Zeng, Benedict Shao Quan Ho, Don Loi Xu, Qiuye Bao, Zi Hao Zheng, Huck‐Hui Ng, Kelly Yu Sing Tan, Huck‐Hui Ng et al. · 2022 · Nucleic Acids Research
19. Targeting protein methylation: from chemical tools to precision medicines
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20. SMYD2 inhibition–mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity
    Ming Tang, Guofang Chen, Bo Tu, Zhiyi Hu, Yujia Huang, Christopher C. DuFort, Xiaoping Wan, Zhiyong Mao, Yongzhong Liu, Wei‐Guo Zhu et al. · 2023 · Science Advances
21. SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression
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22. Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome
    Kyle K. Biggar, François Charih, Huadong Liu, Yasser B. Ruiz‐Blanco, Leanne Stalker, Anand Chopra, Justin Connolly, Hemanta Adhikary, Kristin Frensemier, Matthew Hoekstra et al. · 2020 · Cell Reports
23. On the Need to Tell Apart Fraternal Twins eEF1A1 and eEF1A2, and Their Respective Outfits
    Alberto Mills, Federico Gago · 2021 · International Journal of Molecular Sciences
24. A Positive Correlation Between the EZH2 and PD-L1 Expression in Resected Lung Adenocarcinomas
    Gouji Toyokawa, Kazuki Takada, Tetsuzo Tagawa, Ryuji Hamamoto, Yuichi Yamada, Mototsugu Shimokawa, Yoshinao Oda, Yoshihiko Maehara · 2018 · The Annals of Thoracic Surgery
25. Nuclear E-Cadherin Acetylation Promotes Colorectal Tumorigenesis via Enhancing β-Catenin Activity
    Yongxu Zhao, Tao Yu, Nan Zhang, Jianxia Chen, Peng Zhang, Shuang Li, Lijun Luo, Zhenling Cui, Yue Qin, Feng Liu · 2018 · Molecular Cancer Research
26. Methyltransferase-like 21c methylates and stabilizes the heat shock protein Hspa8 in type I myofibers in mice
    Wang, Chao, Arrington, Justine, Ratliff, Anna C., Chen, Jingjuan, Horton, Hannah E., Nie, Yaohui, Yue, Feng, Hrycyna, Christine A., Tao, W. Andy, Kuang, Shihuan · 2019 · Journal of Biological Chemistry
27. Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia
    Liping Dou, Fei Yan, Jiuxia Pang, Dehua Zheng, Dandan Li, Li Gao, Lijun Wang, Yihan Xu, Jinlong Shi, Qian Wang et al. · 2019 · Nature Communications
28. Recent advances in nuclear receptor-binding SET domain 2 (NSD2) inhibitors: An update and perspectives
    Li Zhang, Xiaoming Zha · 2023 · European Journal of Medicinal Chemistry
29. Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
    Kwangho Kim, Tae Young Ryu, Eunsun Jung, Tae‐Su Han, Jin‐Kwon Lee, Seon‐Kyu Kim, Yuna Roh, Moo‐Seung Lee, Cho‐Rok Jung, Jung Hwa Lim et al. · 2023 · Experimental & Molecular Medicine
30. An integrated genomic analysis of Tudor domain–containing proteins identifies PHD finger protein 20‐like 1 (PHF20L1) as a candidate oncogene in breast cancer
    Yuanyuan Jiang, Lanxin Liu, Wenqi Shan, Zeng-Quan Yang · 2015 · Molecular Oncology
31. The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling
    Shuman Gao, Zhiqiang Wang, Wencai Wang, Xueli Hu, Peilin Chen, Jiwen Li, Xin‐Hua Feng, Jiemin Wong, James X. Du · 2017 · Journal of Biological Chemistry
32. SETD6 dominant negative mutation in familial colorectal cancer type X
    Lorena Martín-Morales, Michal Feldman, Zlata Vershinin, Pilar Garré, Trinidad Caldés, Dan Levy · 2017 · Human Molecular Genetics
33. Histone methyltransferase SMYD2 selective inhibitor LLY-507 in combination with poly ADP ribose polymerase inhibitor has therapeutic potential against high-grade serous ovarian carcinomas
    Asako Kukita, Kenbun Sone, Katsutoshi Oda, Ryuji Hamamoto, Syuzo Kaneko, Masaaki Komatsu, Miku Wada, Harunori Honjoh, Yoshiko Kawata, Machiko Kojima et al. · 2019 · Biochemical and Biophysical Research Communications
34. SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells
    Theodore Vougiouklakis, Kenbun Sone, Vassiliki Saloura, Hyun‐Soo Cho, Takehiro Suzuki, Naoshi Dohmae, Houda Alachkar, Yusuke Nakamura, Ryuji Hamamoto · 2015 · Oncotarget
35. Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastoma
    Yatian Li, Zhenyue Gao, Yuhong Wang, Bo Pang, Binbin Zhang, Ruxin Hu, Yuqing Wang, Chao Liu, Xuebin Zhang, Jingxuan Yang et al. · 2023 · Nature Communications
36. KDM1A and KDM3A promote tumor growth by upregulating cell cycle-associated genes in pancreatic cancer
    Xuyang Hou, Qiuguo Li, Leping Yang, Zhulin Yang, Jun He, Qinglong Li, Daming Li · 2021 · Experimental Biology and Medicine
37. EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerization
    A, Peng, Xu, Xinyi, Wang, Chenglin, Yang, Jing, Wang, Shida, Dai, Jiewen, Ye, Ling · 2018 · Epigenetics & Chromatin
38. High expression of SMYD3 indicates poor survival outcome and promotes tumour progression through an IGF-1R/AKT/E2F-1 positive feedback loop in bladder cancer
    Guoliang Wang, Yi Huang, Feilong Yang, Xiaojun Tian, Kun Wang, Li Liu, Yidong Fan, Xiaofeng Li, Luchao Li, Benkang Shi et al. · 2020 · Aging
39. DNA or Protein Methylation-Dependent Regulation of Activator Protein-1 Function
    Eunji Kim, Akash Ahuja, Mi‐Yeon Kim, Jae Youl Cho · 2021 · Cells
40. The EEF1AKMT3/MAP2K7/TP53 axis suppresses tumor invasiveness and metastasis in gastric cancer
    Yo Han Hong, Nur Aziz, Jae Gwang Park, Dagyeong Lee, Jin Kyeong Kim, Seung A Kim, Wooram Choi, Hwa Pyoung Lee, Hwa Pyoung Lee, Ha Thi Huyen Trang et al. · 2022 · Cancer Letters
41. Tiam1 methylation by NSD2 promotes Rac1 signaling activation and colon cancer metastasis
    Da Song, Fuqing Hu, Changsheng Huang, Jingqin Lan, Xiaowei She, Chongchong Zhao, Hong Wu, Anyi Liu, Qi Wu, Yaqi Chen et al. · 2023 · Proceedings of the National Academy of Sciences
42. SETD6 is a negative regulator of oxidative stress response
    Ayelet Chen, Michal Feldman, Zlata Vershinin, Dan Levy · 2016 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
43. Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis
    Shunsuke Kuroki, Yuji Nakai, Ryo Maeda, Naoki Okashita, Mika Akiyoshi, Yutaro Yamaguchi, Satsuki Kitano, Hitoshi Miyachi, Ryuichiro Nakato, Kenji Ichiyanagi et al. · 2018 · Stem Cell Reports
44. Functions and mechanisms of non-histone post-translational modifications in cancer progression
    Zongyang Li, Tao Zhu, Yushu Wu, Yongbo Yu, Yun-jiang Zang, Lebo Yu, Zhilei Zhang · 2025 · Cell Death Discovery
45. Proteomic Analysis of a Fraction with Intact Eyespots of Chlamydomonas reinhardtii and Assignment of Protein Methylation
    Nicole Eitzinger, Volker Wagner, Wolfram Weisheit, Stefan Geimer, David Boness, Georg Kreimer, Maria Mittag · 2015 · Frontiers in Plant Science
46. Roles of post-translational modifications of UHRF1 in cancer
    Lili Gu, Y H Fu, Xiong Li · 2024 · Epigenetics & Chromatin
47. The histone methyltransferase SMYD2 is a novel therapeutic target for the induction of apoptosis in ovarian clear cell carcinoma cells
    Machiko Kojima, Kenbun Sone, Katsutoshi Oda, Ryuji Hamamoto, Syuzo Kaneko, Shinya Oki, Asako Kukita, Akira Kawata, Harunori Honjoh, Yoshiko Kawata et al. · 2020 · Oncology Letters
48. Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma
    Sangchul Kim, Amina Bolatkan, Syuzo Kaneko, Noriko Ikawa, Ken Asada, Masaaki Komatsu, Shinya Hayami, Hidenori Ojima, Nobutsugu Abe, Hiroki Yamaue et al. · 2019 · Biomolecules
49. Chemical biology and pharmacology of histone lysine methylation inhibitors
    Samir H. Barghout, Raquel A. C. Machado, Dalia Baršytė-Lovejoy · 2022 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
50. Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins
    Lianhua Piao, Makoto Nakakido, Takehiro Suzuki, Naoshi Dohmae, Yusuke Nakamura, Ryuji Hamamoto · 2016 · Oncotarget
51. An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates
    Hazem Ahmed, Shili Duan, C.H. Arrowsmith, Dalia Baršytė-Lovejoy, Matthieu Schapira · 2016 · Journal of Proteome Research
52. Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors
    Ciro Milite, Alessandra Feoli, Monica Viviano, Donatella Rescigno, Antonello Mai, Sabrina Castellano, Gianluca Sbardella · 2016 · ChemMedChem
53. The complexity of epigenetic diseases
    Ailbhe Jane Brazel, Douglas Vernimmen · 2015 · The Journal of Pathology
54. Functional analysis of the methyltransferase SMYD in the single-cell model organism Tetrahymena thermophila
    Xiaolu Zhao, Yuan Li, Lili Duan, Xiao Chen, Fengbiao Mao, Mina Juma, Yifan Liu, WEIBO B. SONG, Shan Gao · 2020 · Marine Life Science & Technology
55. SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk
    Valentina Lukinović, Simone Hausmann, Gaël S. Roth, Clément Oyeniran, Tanveer Ahmad, Ning Tsao, Joshua R. Brickner, Alexandre G. Casanova, Florent Chuffart, Ana Morales Benitez et al. · 2022 · Cancer Discovery
56. MAT2A facilitates PDCD6 methylation and promotes cell growth under glucose deprivation in cervical cancer
    Hui Luo, Yizuo Song, Jianan Zhang, Yi Liu, Fengyun Chen, Zhiwei Peter Wang, Xueqiong Zhu · 2022 · Cell Death Discovery
57. Global lysine methylome profiling using systematically characterized affinity reagents
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58. Enhancer, epigenetics, and human disease
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59. Molecular basis for histidine N3-specific methylation of actin H73 by SETD3
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60. Synthesis and Assays of Inhibitors of Methyltransferases
    Xiao-Chuan Cai, Kanishk Kapilashrami, Minkui Luo · 2016 · Methods in enzymology on CD-ROM/Methods in enzymology
61. Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasis
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62. Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer
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63. Increased serum concentrations of asymmetric dimethylarginine (ADMA) in patients with early-onset coronary artery disease
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64. Lysine Methyltransferases Signaling: Histones are Just the Tip of the Iceberg
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65. DNA damage response and repair pathway modulation by non-histone protein methylation: implications in neurodegeneration
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66. Critical Roles of Protein Arginine Methylation in the Central Nervous System
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67. Analysis of the Substrate Specificity of the SMYD2 Protein Lysine Methyltransferase and Discovery of Novel Non‐Histone Substrates
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68. Functional Interplay between Methyltransferases and Inflammasomes in Inflammatory Responses and Diseases
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69. Histone 3 Lysine 27 Trimethylation Signature in Breast Cancer
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70. SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer
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71. Targeting Suppressor of Variegation 3-9 Homologue 2 (SUV39H2) in Acute Lymphoblastic Leukemia (ALL)
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72. Modulation of the cytoplasmic functions of mammalian post-transcriptional regulatory proteins by methylation and acetylation: a key layer of regulation waiting to be uncovered?
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73. Methyltransferase and demethylase profiling studies during brown adipocyte differentiation
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74. The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation
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75. Subcellular Proteomic Mapping of Lysine Lactylation
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76. Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection
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77. The Histone Methyltransferase SETD8 Regulates the Expression of Tumor Suppressor Genes via H4K20 Methylation and the p53 Signaling Pathway in Endometrial Cancer Cells
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78. Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma
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79. Histone arginine methyltransferase CARM1 selective inhibitor TP-064 induces apoptosis in endometrial cancer
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80. Lysine 68 Methylation‐Dependent SOX9 Stability Control Modulates Chondrogenic Differentiation in Dental Pulp Stem Cells
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81. Post‐translational modifications of protein in response to ionizing radiation
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82. Clinicopathologic significance of protein lysine methyltransferases in cancer
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83. Baicalein Inhibits the SMYD2/RPS7 Signaling Pathway to Inhibit the Occurrence and Metastasis of Lung Cancer
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84. Oligomerization and Auto-methylation of the Human Lysine Methyltransferase SETD6
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85. Integrated genomic analyses identify KDM1A's role in cell proliferation via modulating E2F signaling activity and associate with poor clinical outcome in oral cancer
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86. Peptide inhibition of the SETD6 methyltransferase catalytic activity
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87. Isoform-Specific Lysine Methylation of RORα2 by SETD7 Is Required for Association of the TIP60 Coactivator Complex in Prostate Cancer Progression
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88. Epigenetic reprogramming in gastrointestinal cancer: biology and translational perspectives
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89. Protein Lysine Methyltransferase SMYD2: A Promising Small Molecule Target for Cancer Therapy
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90. Upregulation of PRMT6 by LPS suppresses Klotho expression through interaction with NF‐κB in glomerular mesangial cells
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91. Selective Triazenation Reaction (STaR) of Secondary Amines for Tagging Monomethyl Lysine Post‐Translational Modifications
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92. Protein Methylation in Diabetic Kidney Disease
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93. Protein methyltransferases and demethylases dictate CD8+ T-cell exclusion in squamous cell carcinoma of the head and neck
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94. Novel structural and functional impact of damaging single nucleotide polymorphisms (SNPs) on human SMYD2 protein using computational approaches
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95. SMYD2 aggravates gastrointestinal stromal tumor via upregulation of EZH2 and downregulation of TET1
    Yong Ji, Xiaofeng Xu, Cong Long, Jianjiang Wang, Li Ding, Zhizhong Zheng, Huiping Wu, Liu Yang, Lan Tao, Feng Gao · 2022 · Cell Death Discovery
96. SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair
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97. Lysine methylation signaling in pancreatic cancer
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98. Protein Post-Translational Modification Crosstalk in Acute Myeloid Leukemia Calls for Action
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99. Mechanisms of histone lysine-modifying enzymes: A computational perspective on the role of the protein environment
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100. Chaetocin—A histone methyltransferase inhibitor—Impairs proliferation, arrests cell cycle and induces nucleolar disassembly in Trypanosoma cruzi
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