Cited by 387Cancer-related gene regulationEpigenetics and DNA MethylationRNA modifications and cancer

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Critical roles of non-histone protein lysine methylation in human tumorigenesis

Hamamoto, Ryuji, Saloura, Vassiliki, Nakamura, Yusuke·2015·Nature Reviews Cancer

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Abstract

Several protein lysine methyltransferases and demethylases have been identified to have critical roles in histone modification. A large body of evidence has indicated that their dysregulation is involved in the development and progression of various diseases, including cancer, and these enzymes are now considered to be potential therapeutic targets. Although most studies have focused on histone methylation, many reports have revealed that these enzymes also regulate the methylation dynamics of non-histone proteins such as p53, RB1 and STAT3 (signal transducer and activator of transcription 3), which have important roles in human tumorigenesis. In this Review, we summarize the molecular functions of protein lysine methylation and its involvement in human cancer, with a particular focus on lysine methylation of non-histone proteins.

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Authors: Hamamoto, R., Saloura, V., & Nakamura, Y.
Affiliations: University of Chicago (US)
Corresponding author: Hamamoto, Ryuji
ORCID: Hamamoto, Ryuji
Saloura, Vassiliki
Nakamura, Yusuke
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2015-01-23
Volume: 15
Issue: 2
Pages: 110-124
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc3884
OpenAlex: W2036357556
Cited by: 376
References: 167
Citations by year: 2026: 14 · 2025: 20 · 2024: 27 · 2023: 29 · 2022: 36 · 2021: 30 · 2020: 39 · 2019: 38 · 2018: 33 · 2017: 38 · 2016: 49 · 2015: 22
FWCI: 4.69
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
Keywords: carcinogenesis, p53, RB1, STAT3, lysine methyltransferase, demethylases, cancer therapy targets, histone modifications
MeSH terms: Cell Transformation, Neoplastic, Chromosomal Proteins, Non-Histone, Humans, Lysine, Methylation, Histone-Lysine N-Methyltransferase, Tumor Suppressor Protein p53, Retinoblastoma Protein, STAT3 Transcription Factor

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Critical roles of non-histone protein lysine methylation in human tumorigenesis

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