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Emerging molecular markers of cancer
Abstract
Alterations in gene sequences, expression levels and protein structure or function have been associated with every type of cancer. These 'molecular markers' can be useful in detecting cancer, determining prognosis and monitoring disease progression or therapeutic response. But what is the best way to identify molecular markers and can they be easily incorporated into the clinical setting?
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“Genetic and molecular markers of malignant tumors have been integrated into clinical practice 5,6 , with the US Food and Drug Administration (FDA) providing approval for several companion diagnostic devices and nucleic acid-based tests 7,8 .”
From Multimodal biomedical AI (2022) · cites this paper as [5]
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Metadata
- Authors
- Sidransky, D.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Sidransky, David
- ORCID
- Sidransky, David
- Venue
- Nature Reviews Cancer
- Published
- 2002-03
- Volume
- 2
- Issue
- 3
- Pages
- 210-219
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2010444010
- Cited by
- 662
- References
- 100
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 14 · 2023: 15 · 2022: 14 · 2021: 17 · 2020: 18 · 2019: 13 · 2018: 16 · 2017: 18 · 2016: 30 · 2015: 34 · 2014: 33 · 2013: 33 · 2012: 35
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- molecular markers, tumor markers, cancer detection, prognosis, disease progression monitoring, treatment response monitoring, gene expression changes, protein structure-function relationship, clinical implementation
- MeSH terms
- DNA, Genetic Markers, Humans, Mutation, Neoplasms, Sensitivity and Specificity, Oligonucleotide Array Sequence Analysis
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