Cited by 662Cancer Genomics and DiagnosticsGene expression and cancer classificationCancer-related Molecular Pathways

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Emerging molecular markers of cancer

Sidransky, David·2002·Nature Reviews Cancer

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Abstract

Alterations in gene sequences, expression levels and protein structure or function have been associated with every type of cancer. These 'molecular markers' can be useful in detecting cancer, determining prognosis and monitoring disease progression or therapeutic response. But what is the best way to identify molecular markers and can they be easily incorporated into the clinical setting?

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Crossref · 10.1038/nrc755

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Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
Herman, J. G., Graff, J. R., Myöhänen, S., Nelkin, B. D., & Baylin, S. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9821 · Cited by 5,634
Serial Analysis of Gene Expression
Velculescu, V. E., Zhang, L., Vogelstein, B., & Kinzler, K. W. (1995) · Science · doi:10.1126/science.270.5235.484 · Cited by 3,713
Use of proteomic patterns in serum to identify ovarian cancer
Petricoin, E. F., Ardekani, A. M., Hitt, B. A., Levine, P. J., Fusaro, V. A., Steinberg, S. M., Mills, G. B., Simone, C., Fishman, D. A., Kohn, E. C., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07746-2 · Cited by 3,236
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256
A gene hypermethylation profile of human cancer.
Esteller, M., Corn, P. G., Baylin, S. B., & Herman, J. G. (2001) · PubMed · Cited by 2,032
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E. W., Burger, P. C., Baylin, S. B., & Sidransky, D. (1995) · Nature Medicine · doi:10.1038/nm0795-686 · Cited by 1,992
Self-citation
Hepatogastroenterology
Xu, D., He, X., Chang, Y., Sun, S., Xu, C., & Lin, J. (2012) · Hepatogastroenterology · doi:10.5754/hge12458 · Cited by 1,977
Untitled work
(1977) · PubMed · Cited by 1,801
DNA hypermethylation in tumorigenesis: epigenetics joins genetics
Baylin, S. B., & Herman, J. G. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01971-x · Cited by 1,615

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Villanueva, J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26022 · Cited by 738
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Lee, H., Sun, E., Ham, D., & Weissleder, R. (2008) · Nature Medicine · doi:10.1038/nm.1711 · Cited by 621
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He, Y., Wu, J., Dressman, D. C., Iacobuzio–Donahue, C. A., Markowitz, S. D., Velculescu, V. E., Diaz, L. A., Kinzler, K. W., Vogelstein, B., & Papadopoulos, N. (2010) · Nature · doi:10.1038/nature08802 · Cited by 516
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Shen, L., Kondo, Y., Rosner, G. L., Xiao, L., Hernandez, N., Vilaythong, J. N., Houlihan, P., Krouse, R. S., Prasad, A. R., Einspahr, J. G., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji275 · Cited by 492
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John, M. A. R. S., Li, Y., Zhou, X. C., Denny, P., Ho, C., Montemagno, C. D., Shi, W., Qi, F., Wu, B. M., Sinha, U. K., et al. (2004) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.130.8.929 · Cited by 424
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Self-citation
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Cancer Biomarkers: Are We Ready for the Prime Time?
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Cancer biomarkers - current perspectives.
Bhatt, A. N., Mathur, R., Farooque, A., Verma, A., & Dwarakanath, B. S. R. (2010) · PubMed · Cited by 239
Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival.
Kinch, M. S., Moore, M.-B. H., & Harpole, D. H. (2003) · PubMed · Cited by 235
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Heitzer, E., Auer, M., Hoffmann, E. M., Pichler, M., Gasch, C., Ulz, P., Lax, S., Waldispuehl‐Geigl, J., Mauermann, O., Mohan, S., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28030 · Cited by 176
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Kim, D., Daniel, W. L., & Mirkin, C. A. (2009) · Analytical Chemistry · doi:10.1021/ac9018389 · Cited by 174
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Tan, D. S. W., THOMAS, G. V., Garrett, M. D., Banerji, U., Bono, J. S. D., Kaye, S. B., & Workman, P. (2009) · The Cancer Journal · doi:10.1097/ppo.0b013e3181bd0445 · Cited by 173
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Mandelker, D. L., Yamashita, K., Tokumaru, Y., Mimori, K., Howard, D. L., Tanaka, Y., Carvalho, A. L., Jiang, W.-W., Park, H. L., Kim, M. S., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3923 · Cited by 167
Self-citation
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Serum levels of interleukin-6 in patients with primary head and neck squamous cell carcinoma.
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Chikkaveeraiah, B. V., Bhirde, A. A., Malhotra, R., Patel, V., Gutkind, J. S., & Rusling, J. F. (2009) · Analytical Chemistry · doi:10.1021/ac9018022 · Cited by 151
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Liedl, T., Dietz, H., Yurke, B., & Simmel, F. C. (2007) · Small · doi:10.1002/smll.200700366 · Cited by 150
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Self-citation
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Authors: Sidransky, D.
Affiliations: Johns Hopkins University (US)
Corresponding author: Sidransky, David
ORCID: Sidransky, David
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2002-03
Volume: 2
Issue: 3
Pages: 210-219
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc755
OpenAlex: W2010444010
Cited by: 662
References: 100
Citations by year: 2026: 3 · 2025: 6 · 2024: 14 · 2023: 15 · 2022: 14 · 2021: 17 · 2020: 18 · 2019: 13 · 2018: 16 · 2017: 18 · 2016: 30 · 2015: 34 · 2014: 33 · 2013: 33 · 2012: 35
FWCI: 3.08
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: molecular markers, tumor markers, cancer detection, prognosis, disease progression monitoring, treatment response monitoring, gene expression changes, protein structure-function relationship, clinical implementation
MeSH terms: DNA, Genetic Markers, Humans, Mutation, Neoplasms, Sensitivity and Specificity, Oligonucleotide Array Sequence Analysis

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