The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Molecular imaging of cardiovascular disease with contrast-enhanced ultrasonography
Abstract
Techniques for noninvasive imaging of specific disease-related molecular changes are being developed to enhance diagnosis and therapeutic decision making in the clinical setting, and to facilitate research efforts. Molecular imaging with contrast-enhanced ultrasonography relies on the detection of the acoustic signal produced by microbubble or nanoparticle agents that are targeted to sites of disease. This Review describes the basis for ultrasound molecular imaging, the unique features of contrast agent behavior or detector performance in relation to clinical or research needs, and the progress that has been made to date in imaging key events in cardiovascular medicine, such as atherosclerosis, postischemic inflammation, angiogenesis, transplant rejection and thrombus formation.
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“The echogenicity for effective ultrasound-mediated imaging favours the use of probes that are larger than nanoparticles, including microbubbles and larger liposomes that are 500–800 nm in size155.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [155]
Citations
Cites
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Imaging Tumor Angiogenesis With Contrast Ultrasound and Microbubbles Targeted to α v β 3
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Self-citationMolina, C. A., Ribó, M., Rubiera, M., Montaner, J., Santamarina, E., Delgado‐Mederos, R., Arenillas, J. F., Huertas, R., Purroy, F. F., Delgado, P., et al. (2005) · Stroke · doi:10.1161/01.str.0000199064.94588.39 · Cited by 451
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Self-citationA Novel Site-Targeted Ultrasonic Contrast Agent With Broad Biomedical Application
Lanza, G. M., Wallace, K. D., Scott, M. J., Cacheris, W. P., Abendschein, D. R., Christy, D. H., Sharkey, A. M., Miller, J. G., Gaffney, P. J., & Wickline, S. A. (1996) · Circulation · doi:10.1161/01.cir.94.12.3334 · Cited by 406
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Research works printed but not linked: 1
- Kaufmann, B. A. et al. Molecular imaging of endothelial cell activation predicts future atherosclerotic plaque development [abstract 904-253]. J. Am. Coll. Cardiol. 51 (Suppl. A), A125 (2008).
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Items 101–111 of 111
Bioabsorbable Stent Quo Vadis: A Case for
Gundogan, B., Tan, A., Farhatnia, Y., Alavijeh, M. S., & Cui, Z. (2014)
Evaluation in vitro of new polymeric contrast microbubbles using Qontrast software
Migaleddu, V. (2012) · European Society of Radiology · doi:10.1594/ecr2012/b-0970
Contrast-Enhanced Ultrasound for the Assessment of Response to Therapy
Rojas, J. D. (2018) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/76n1-1j78
Contrast Enhanced Ultrasound: An Overview
Nema, N. T. A., Rawat, S. K. S. K., & Vandre, R. K. (2021) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2021.1010.064
Imaging in Cardiovascular Research
Schäfers, M. A., Tiemann, K., Kuhlmann, M. T., Stegger, L., Schäfers, K. P., & Hermann, S. (2010) · Springer eBooks · doi:10.1007/978-3-642-12945-2_31
Current Awareness in Contrast Media and Molecular Imaging
(2010) · Contrast Media & Molecular Imaging · doi:10.1002/cmmi.283
Gać, P., Jaworski, A., Parfianowicz, A., Surma, A., Jakubowska-Martyniuk, A., Żórawik, A., & Poręba, R. (2024) · Diagnostics · doi:10.3390/diagnostics14222496
Drug Delivery to the Cardiovascular System: Application and Future Prospects
Umar, P. K., Jyoti, J., Asha, A., & Jain, S. K. (2025) · Methods in pharmacology and toxicology · doi:10.1007/978-1-0716-4554-3_15
D, G. D. D., Shunmugavelu, K., & Dhinakaran, E. C. (2025) · Student s Journal of Health Research Africa · doi:10.51168/sjhrafrica.v6i12.2203
Li, X., Chen, J., Sun, P., Zhao, C., Zhang, X., Zhao, P., Liu, J., Shan, J., Yu, D., Yin, L., et al. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116589
Luo, Y., Huang, L., Zhao, J., Ma, Y., Tan, X., Ye, F., Zhao, S., Hu, S., & Zhang, L. (2026) · Small · doi:10.1002/smll.75061
Metadata
- Authors
- Lindner, J. R.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Lindner, Jonathan R.
- ORCID
- Lindner, Jonathan R.
- Venue
- Nature Reviews Cardiology
- Published
- 2009-06-09
- Volume
- 6
- Issue
- 7
- Pages
- 475-481
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W2092160452
- Cited by
- 111
- References
- 40
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 9 · 2014: 8 · 2013: 9 · 2012: 9
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- molecular imaging, contrast-enhanced ultrasound, targeted ultrasound contrast agents, microbubbles, nanoparticle contrast agents, atherosclerosis, post-ischemic inflammation, angiogenesis, graft rejection, thrombus formation, non-invasive imaging
- MeSH terms
- Animals, Cardiovascular Diseases, Contrast Media, Humans, Inflammation, Neovascularization, Pathologic, Predictive Value of Tests, Thrombosis, Ultrasonography, Interventional, Neovascularization, Physiologic, Microbubbles, Nanoparticles
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