The DOI matches its Crossref record; 121 of the 122 references it cites were found in a registry or an index.
The relationship between blood pressure and cognitive function
Open accessAbstract
The relationship between blood pressure (BP) and cognitive outcomes in elderly adults has implications for global health care. Both hypertension and hypotension affect brain perfusion and worsen cognitive outcomes. The presence of hypertension and other vascular risk factors has been associated with decreased performance in executive function and attention tests. Cerebrovascular reserve has emerged as a potential biomarker for monitoring pressure-perfusion-cognition relationships. A decline in vascular reserve capacity can lead to impaired neurovascular coupling and decreased cognitive ability. Endothelial dysfunction, microvascular disease, and mascrovascular disease in midlife could also have an important role in the manifestations and severity of multiple medical conditions underlying cognitive decline late in life. However, questions remain about the role of antihypertensive therapies for long-term prevention of cognitive decline. In this Review, we address the underlying pathophysiology and the existing evidence supporting the role of vascular factors in late-life cognitive decline.
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“In particular, high blood pressure has been linked with the pathophysiology of MCI other than with Alzheimer disease and vascular dementia.10,11”
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The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
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Metadata
- Authors
- Novak, V., & Hajjar, I.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Novak, Vera
- Venue
- Nature Reviews Cardiology
- Published
- 2010-10-26
- Volume
- 7
- Issue
- 12
- Pages
- 686-698
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- PMC
- PMC3328310
- OpenAlex
- W2048075564
- Cited by
- 299
- References
- 122
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 24 · 2021: 15 · 2020: 20 · 2019: 29 · 2018: 15 · 2017: 28 · 2016: 16 · 2015: 19 · 2014: 30 · 2013: 31 · 2012: 20
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (1R01AG028076-A2, R01AG028076, P30AG028717, 1P01AG028717-01A2, K23AG030057)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK084463)
- National Institute of Neurological Disorders and Stroke (R01NS045745)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- blood pressure, cognitive decline, dementia, hypertension, hypotension, cerebral perfusion, cerebrovascular reserve, neurovascular coupling, vascular risk factors, endothelial dysfunction, microangiopathy, macroangiopathy, antihypertensive therapy, executive function, attention, older adults
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Antihypertensive Agents, Blood Pressure, Cognition, Cognition Disorders, Female, Humans, Hypertension, Hypotension, Male, Middle Aged, Risk Factors, Risk Assessment
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