Cited by 299Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsBlood Pressure and Hypertension Studies

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The relationship between blood pressure and cognitive function

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Novak, Vera, Hajjar, Ihab·2010·Nature Reviews Cardiology

DOI 10.1038/nrcardio.2010.161PMC PMC3328310

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Abstract

The relationship between blood pressure (BP) and cognitive outcomes in elderly adults has implications for global health care. Both hypertension and hypotension affect brain perfusion and worsen cognitive outcomes. The presence of hypertension and other vascular risk factors has been associated with decreased performance in executive function and attention tests. Cerebrovascular reserve has emerged as a potential biomarker for monitoring pressure-perfusion-cognition relationships. A decline in vascular reserve capacity can lead to impaired neurovascular coupling and decreased cognitive ability. Endothelial dysfunction, microvascular disease, and mascrovascular disease in midlife could also have an important role in the manifestations and severity of multiple medical conditions underlying cognitive decline late in life. However, questions remain about the role of antihypertensive therapies for long-term prevention of cognitive decline. In this Review, we address the underlying pathophysiology and the existing evidence supporting the role of vascular factors in late-life cognitive decline.

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Authors: Novak, V., & Hajjar, I.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Novak, Vera
ORCID: Novak, Vera
Hajjar, Ihab
Venue: Nature Reviews Cardiology
Publisher: Springer Science and Business Media LLC
Published: 2010-10-26
Volume: 7
Issue: 12
Pages: 686-698
ISSN: 1759-5002 (ISSN-L)
1759-5010
DOI: 10.1038/nrcardio.2010.161
PMC: PMC3328310
OpenAlex: W2048075564
Cited by: 299
References: 122
Citations by year: 2026: 11 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 24 · 2021: 15 · 2020: 20 · 2019: 29 · 2018: 15 · 2017: 28 · 2016: 16 · 2015: 19 · 2014: 30 · 2013: 31 · 2012: 20
FWCI: 2.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Cardiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (1R01AG028076-A2, R01AG028076, P30AG028717, 1P01AG028717-01A2, K23AG030057)
National Institute of Diabetes and Digestive and Kidney Diseases (R21DK084463)
National Institute of Neurological Disorders and Stroke (R01NS045745)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: blood pressure, cognitive decline, dementia, hypertension, hypotension, cerebral perfusion, cerebrovascular reserve, neurovascular coupling, vascular risk factors, endothelial dysfunction, microangiopathy, macroangiopathy, antihypertensive therapy, executive function, attention, older adults
MeSH terms: Age Factors, Aged, Aged, 80 and over, Antihypertensive Agents, Blood Pressure, Cognition, Cognition Disorders, Female, Humans, Hypertension, Hypotension, Male, Middle Aged, Risk Factors, Risk Assessment

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