Natriuretic peptides in cardiometabolic regulation and disease
Abstract
In the 30 years since the identification of the natriuretic peptides, their involvement in regulating fluid and blood pressure has become firmly established. Data indicating a role for these hormones in lifestyle-related metabolic and cardiovascular disorders have also accumulated over the past decade. Dysregulation of the natriuretic peptide system has been associated with obesity, glucose intolerance, type 2 diabetes mellitus, and essential hypertension. Moreover, the natriuretic peptides have been implicated in the protection against atherosclerosis, thrombosis, and myocardial ischaemia. All these conditions can coexist and potentially lead to heart failure, a syndrome associated with a functional natriuretic peptide deficiency despite high circulating concentrations of immunoreactive peptides. Therefore, dysregulation of the natriuretic peptide system, a 'natriuretic handicap', might be an important factor in the initiation and progression of metabolic dysfunction and its accompanying cardiovascular complications. This Review provides a summary of the natriuretic peptide system and its involvement in these cardiometabolic conditions. We propose that these peptides might have an integrating role in lifestyle-related metabolic and cardiovascular disorders.
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Pro-hormone assays for natriuretic peptides are more stable and precise than assays measuring the intact peptides.
“The preferred NPs to measure are the pro-hormones due to the fact that these assays are more stable and precise than assays measuring the intact peptides (7).”
From Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS (2018) · cites this paper as [7]
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- Authors
- Zois, N. E., Bartels, E. D., Hunter, I., Kousholt, B. S., Olsen, L. H., & Goetze, J. P.
- Affiliations
- Copenhagen University Hospital (DK)
- Aarhus University (DK)
- University of Copenhagen (DK)
- Corresponding author
- Goetze, Jens P.
- Venue
- Nature Reviews Cardiology
- Published
- 2014-05-13
- Volume
- 11
- Issue
- 7
- Pages
- 403-412
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W2093885131
- Cited by
- 182
- References
- 7
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 3 · 2023: 13 · 2022: 22 · 2021: 12 · 2020: 19 · 2019: 14 · 2018: 19 · 2017: 15 · 2016: 21 · 2015: 25 · 2014: 3
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Novo Nordisk Fonden (NNF12OC1016060)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- natriuretic peptides, obesity, type 2 diabetes, essential hypertension, atherosclerosis, thrombosis, myocardial ischemia, heart failure, impaired glucose tolerance
- MeSH terms
- Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Obesity, Biomarkers, Glucose Intolerance, Natriuretic Peptides
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