CoChat
Sign Up
Cited by 58Renin-Angiotensin System StudiesSodium Intake and HealthBlood Pressure and Hypertension Studies

Relative Atrial Natriuretic Peptide Deficiency and Inadequate Renin and Angiotensin II Suppression in Obese Hypertensive Men

Asferg, Camilla L., Nielsen, Søren J., Andersen, Ulrik B., Linneberg, Allan, Møller, Daniel V., Hedley, Paula L., Christiansen, Michael, Goetze, Jens P. +2 more·2013·Hypertension
DOI 10.1161/hypertensionaha.111.00791
Open this paper in CoChat — free account

Abstract

Obesity is a strong risk factor for hypertension, but the mechanisms by which obesity leads to hypertension are incompletely understood. On this background, we assessed dietary sodium intake, serum levels of natriuretic peptides (NPs), and the activity of the renin–angiotensin system in 63 obese hypertensive men (obeseHT: body mass index, ≥30.0 kg/m 2 ; 24-hour ambulatory blood pressure, ≥130/80 mm Hg), in 40 obese normotensive men (obeseNT: body mass index, ≥30.0 kg/m 2 ; 24-hour ambulatory blood pressure, <130/80 mm Hg), and in 27 lean normotensive men (leanNT: body mass index, 20.0–24.9 kg/m 2 ; 24-hour ambulatory blood pressure, <130/80 mm Hg). All study subjects were medication free. As a surrogate estimate for dietary sodium intake, we measured sodium excretion in a 24-hour urine collection and we measured serum levels of midregional proatrial NP and plasma levels of renin and angiotensin II. The obese men had higher mean (±SD) urinary sodium excretion (obeseHT, 213.6±85.2 mmol; obeseNT, 233.0±70.0 mmol) than the lean normotensive men (leanNT, 155.5±51.7 mmol; P =0.003). ObeseHT had lower (median [interquartile range]) serum midregional proatrial NP levels (49.2 [37.3–64.7] pmol/L) than leanNT (69.3 [54.3–82.9] pmol/L; P =0.003), whereas obeseNT had midregional proatrial NP levels in between (54.1 [43.2–64.7] pmol/L); obeseNT had lower (median [interquartile range]) plasma levels of renin (5.0 [3.0–8.0] mIU/L versus 9.0 [4.0–18.0]) and angiotensin II (2.4 [1.5–3.5] pmol/L versus 4.2 [2.2–7.9]) than obeseHT ( P ≤0.049), whereas obeseHT had similar plasma levels of renin and angiotensin II as leanNT ( P ≥0.19). Thus, despite a high sodium intake and a high blood pressure, obese hypertensive men have a relative NP deficiency and an inadequate renin–angiotensin system suppression.

Integrity signals

Registry

Crossref · 10.1161/hypertensionaha.111.00791

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Increases in natriuretic peptides associated with high salt intake and volume loading are diminished in obese compared with lean individuals.

    “Increases in NPs associated with high salt intake and volume loading are also diminished in obese compared with lean individuals90–92.”

    From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [90]

  • Men with obesity and hypertension had lower plasma pro-ANP levels than normotensive lean men despite greater sodium intake and larger left atria.

    “Men with obesity and hypertension had lower plasma pro ANP levels than normotensive lean men despite greater sodium intake and larger left atria90,91.”

    From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [90]

  • Obese hypertensive men have lower levels of proatrial natriuretic peptide despite higher sodium intake compared to lean normotensive men.

    “For example, obese hypertensive men have lower levels of proatrial natriuretic peptide despite higher sodium intake compared to lean normotensive men22.”

    From Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms (2015) · cites this paper as [22]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Asferg, C. L., Nielsen, S. J., Andersen, U. B., Linneberg, A., Møller, D. V., Hedley, P. L., Christiansen, M., Goetze, J. P., Esler, M., & Jeppesen, J. L.
Affiliations
  • Statens Serum Institut (DK)
  • From the Department of Clinical Physiology and Nuclear Medicine (C.L.A., U.B.A.), The Research Centre for Prevention and Health (A.L.), and the Department of Medicine (J.L.J.), Copenhagen University Hospital Glostrup, Denmark; the Department of Cardiology, Copenhagen University Hospital Gentofte, Denmark (S.J.N.); Statens Serum Institut, Copenhagen, Denmark (D.V.M., P.L.H., M.C.); the Department of Clinical Chemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark (J.P.G.); the...
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-07
Volume
62
Issue
1
Pages
147-153
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hypertensionaha.111.00791
OpenAlex
W2109945521
Cited by
58
References
44
Citations by year
2025: 4 · 2023: 2 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 4
FWCI
5.21
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
obesity, atrial natriuretic peptide, MR-proANP, renin-angiotensin system, angiotensin II, sodium intake, sodium excretion, renin suppression, men, body mass index, ambulatory blood pressure, renin-angiotensin system blockade
MeSH terms
Adult, Aged, Angiotensin II, Blood Pressure, Body Composition, Follow-Up Studies, Humans, Hypertension, Male, Middle Aged, Atrial Natriuretic Factor, Obesity, Prognosis, Renin, Renin-Angiotensin System, Blood Pressure Monitoring, Ambulatory

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review