The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Chimeric antigen receptor T-cell therapies for lymphoma
Open accessAbstract
New therapies are needed for patients with Hodgkin or non-Hodgkin lymphomas that are resistant to standard therapies. Indeed, unresponsiveness to standard chemotherapy and relapse after autologous stem-cell transplantation are indicators of an especially poor prognosis. Chimeric antigen receptor (CAR) T cells are emerging as a novel treatment modality for these patients. Clinical trial data have demonstrated the potent activity of anti-CD19 CAR T cells against multiple subtypes of B-cell lymphoma, including diffuse large-B-cell lymphoma (DLBCL), follicular lymphoma, mantle-cell lymphoma, and marginal-zone lymphoma. Importantly, anti-CD19 CAR T cells have impressive activity against chemotherapy-refractory lymphoma, inducing durable complete remissions lasting >2 years in some patients with refractory DLBCL. CAR-T-cell therapies are, however, associated with potentially fatal toxicities, including cytokine-release syndrome and neurological toxicities. CAR T cells with novel target antigens, including CD20, CD22, and κ-light chain for B-cell lymphomas, and CD30 for Hodgkin and T-cell lymphomas, are currently being investigated in clinical trials. Centrally manufactured CAR T cells are also being tested in industry-sponsored multicentre clinical trials, and will probably soon become a standard therapy. Herein, we review the clinical efficacy and toxicity of CAR-T-cell therapies for lymphoma, and discuss their limitations and future directions with regard to toxicity management, CAR designs and CAR-T-cell phenotypes, conditioning regimens, and combination therapies.
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Chimeric Antigen Receptor Therapy
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Metadata
- Authors
- Brudno, J. N., & Kochenderfer, J. N.
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2017-08-31
- Volume
- 15
- Issue
- 1
- Pages
- 31-46
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- OpenAlex
- W2751416367
- Cited by
- 516
- References
- 142
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- green
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