The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
Unravelling the biology of SCLC: implications for therapy
Open accessAbstract
Small-cell lung cancer (SCLC) is an aggressive malignancy associated with a poor prognosis. First-line treatment has remained unchanged for decades, and a paucity of effective treatment options exists for recurrent disease. Nonetheless, advances in our understanding of SCLC biology have led to the development of novel experimental therapies. Poly [ADP-ribose] polymerase (PARP) inhibitors have shown promise in preclinical models, and are under clinical investigation in combination with cytotoxic therapies and inhibitors of cell-cycle checkpoints.Preclinical data indicate that targeting of histone-lysine N-methyltransferase EZH2, a regulator of chromatin remodelling implicated in acquired therapeutic resistance, might augment and prolong chemotherapy responses. High expression of the inhibitory Notch ligand Delta-like protein 3 (DLL3) in most SCLCs has been linked to expression of Achaete-scute homologue 1 (ASCL1; also known as ASH-1), a key transcription factor driving SCLC oncogenesis; encouraging preclinical and clinical activity has been demonstrated for an anti-DLL3-antibody–drug conjugate. The immune microenvironment of SCLC seems to be distinct from that of other solid tumours, with few tumour-infiltrating lymphocytes and low levels of the immune-checkpoint protein programmed cell death 1 ligand 1 (PD-L1). Nonetheless, immunotherapy with immune-checkpoint inhibitors holds promise for patients with this disease, independent of PD-L1 status. Herein, we review the progress made in uncovering aspects of the biology of SCLC and its microenvironment that are defining new therapeutic strategies and offering renewed hope for patients.
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Cited by
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data
Rudin, C. M., Poirier, J. T., Byers, L. A., Dive, C., Dowlati, A., George, J., Heymach, J. V., Johnson, J. E., Lehman, J. M., MacPherson, D., et al. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0133-9 · Cited by 1,254
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Metadata
- Authors
- Sabari, J. K., Lok, B. H., Laird, J. H., Poirier, J. T., & Rudin, C. M.
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2017-05-23
- Volume
- 14
- Issue
- 9
- Pages
- 549-561
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- OpenAlex
- W2617007913
- Cited by
- 490
- References
- 140
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Sabari, J. K., Lok, B. H., Laird, J. H., Poirier, J. T., & Rudin, C. M. (2017). Unravelling the biology of SCLC: implications for therapy. Nature Reviews Clinical Oncology. https://doi.org/10.1038/nrclinonc.2017.71
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