The Ever-Expanding Myokinome: Discovery Challenges and Therapeutic Implications

Whitham, Martin, Febbraio, Mark A.·2016·Nature Reviews Drug Discovery
DOI 10.1038/nrd.2016.153

Cited by (279)

Items 201–279 of 279

  1. Myokine Circulating Levels in Postmenopausal Women with Overweight or Obesity: Effects of Resistance Training and/or DHA-Rich n-3 PUFA Supplementation
    Alejandro Martínez-Gayo, Elisa Félix‐Soriano, Javier Ibáñez-Santos, Marisol García‐Unciti, Pedro González‐Muniesa, María Jesús Moreno-Aliaga, on behalf of OBELEX Project · 2025 · Nutrients
  2. Pathophysiological, Translational, and Diagnostic Aspects of ME/CFS: A Focus on Skeletal Muscle Involvement
    Giorgio Fanò, Francesco Coscia, Paola Virginia Gigliotti, Franco Checcaglini, Ugo Carraro, Stefania Fulle, Rosa Mancinelli · 2026 · Diagnostics
  3. The Myokine Adaptome in Health and Disease: Exercise-Induced Cellular Signaling, Muscle–Organ Crosstalk, and Therapeutic Plasticity
    Dan Cristian Mănescu, Camelia Daniela Plastoi, Ancuta Pîrvan, Rodica Dîrnu, Elena Ancuța Floroiu, Andreea Popescu · 2026 · Cells
  4. Enviromimetics: From exercise mimetics to cognitomimetics in the quest for enhanced brain health and cognition
    Anthony John Hannan · 2025 · The Journal of Physiology
  5. “Remote” myokine protects from pulmonary ischemia/reperfusion injury by a surprising “proximal” control mechanism
    Jürgen Bernhagen · 2018 · Annals of Translational Medicine
  6. Distinct Effects of High-Fat and High-Phosphate Diet on Glucose Metabolism and the Response to Voluntary Exercise in Male Mice
    Pablo Vidal, Lisa A. Baer, Elisa Félix‐Soriano, Felix T. Yang, Daniel A. Branch, Kedryn K. Baskin, Kristin I. Stanford · 2022 · Nutrients
  7. Local and systemic transcriptomic responses from acute exercise induced muscle damage of the human knee extensors
    Eric A. Kirk, Christina A. Castellani, Timothy J. Doherty, Charles L. Rice, Shiva M. Singh · 2022 · Physiological Genomics
  8. Comparison of Whole-Body Electrical Stimulation with Aerobic Exercise on Body Composition and Serum Irisin Level in Overweight Adolescents
    Gabrial Pouzesh Jadidi · 2024 · Physical activity in children.
  9. Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation
    Lidan Zhang, Takayuki Kaji, Ayasa Nakamura, Nagomu Maesawa, Kanako Iwamori, Jiayao Xu, Yilin Liu, Akiyoshi Uezumi, Daisuke Kamimura, Masaaki Murakami et al. · 2025 · Nature Communications
  10. The metabolic role of corticotropin-releasing hormone receptor 2 and its UCN peptides: emerging therapeutic potential
    Pablo Vidal, Natalie R. Janzen, Joseph T. Brozinick · 2025 · Skeletal Muscle
  11. The hallmarks of skeletal muscle health
    Anna Vainshtein, Bert Blaauw, Katrien De Bock, Pura Muñoz‐Cánoves, Eric N. Olson, Coen A. C. Ottenheijm, Erik Arne Richter, Jorge Lira Ruas, Laurent Schaeffer, Bruce M. Spiegelman et al. · 2026 · Nature Metabolism
  12. Integrated procedures for accelerating, deepening, and leading genetic inquiry: A first application on human muscle secretome
    Danilo Bondi, Michele Bevere, Rosanna Piccirillo, Guglielmo Sorci, Valentina Di Felice, Andrea David Re Cecconi, Daniela C.S. Damico, Tiziana Pietrangelo, Stefania Fulle · 2023 · Molecular Genetics and Metabolism
  13. ATPase Inhibitory Factor 1—A Novel Marker of Cellular Fitness and Exercise Capacity?
    Remigiusz Domin, Michał Pytka, Jan Niziński, Mikołaj Żołyński, Ariadna Zybek‐Kocik, Elżbieta Wrotkowska, Jacek Zieliński, Przemysław Guzik, Marek Ruchała · 2022 · International Journal of Molecular Sciences
  14. Mechanisms of Exercise in Cancer Prevention, Treatment, and Survivorship
    Hannah Savage, Keri Schadler · 2020 · Springer eBooks
  15. Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel
    Tengteng Huang, Xiaoling Chen, Jun He, Ping Zheng, Yuheng Luo, Aimin Wu, Hui Yan, Bing Yu, Daiwen Chen, Zhiqing Huang · 2024 · eLife
  16. Radiation-induced impairment of skeletal muscle regeneration
    Maja Čemažar, Mihaela Jurdana · 2025 · Radiology and Oncology
  17. Exerkines in diabetic retinopathy: from mechanisms to therapeutic prospects
    Juming Zhu · 2026 · Frontiers in Endocrinology
  18. Neuroligin-3: A Novel Exercise-Induced Secreted Factor Enhancing Insulin Sensitivity in Obese Insulin-Resistant Mice
    Archana Sinha, Debarun Patra, Subrata Mishra, Ankit Vashisth, Shivam Sharma, Upalabdha Dey, Palla Ramprasad, Soumyajit Roy, Aditya Kumar, Kulbhushan Tikoo et al. · 2026 · Diabetes
  19. The emerging role of the Hippo signaling pathway in interorgan crosstalk
    Gahyeon Song, Chaerin Lee, E. Jho · 2026 · The FEBS Journal
  20. Exercise-evoked immunometabolic niches coordinate context-dependent muscle metabolism
    Makoto Kanzaki · 2026 · Trends in Endocrinology and Metabolism
  21. Physical activity learning by medical students: the current picture in Brazil
    Cristiane Soares Ferreira Bortolini, Amanda Capeloto Mastro, Gabriel Marcos Barbosa, Rafael Resende, Luciana Alves de Medeiros, Rita do Socorro Uchôa da Silva, Nilson Penha‐Silva, Miguel Júnior Sordi Bortolini · 2021 · Revista Brasileira de Educação Médica
  22. Studies in Rats of Combined Muscle and Liver Perfusion and of Muscle Extract Indicate That Contractions Release a Muscle Hormone Directly Enhancing Hepatic Glycogenolysis
    Xiao X. Han, Jens Juul Holst, H. Galbo · 2022 · Journal of Personalized Medicine
  23. Effects of Common Myokines on Diabetes Mellitus
    Zhu Yu, Qingqing Liu, Yurong Zhu, Tiantian Guo, Mengtong Jin, Jiali Hao, Chao Qi, Xiaofeng Miao, Duan Xi, Jiamao Fan et al. · 2022 · Journal of Diabetes Mellitus
  24. Exercise and Diet in the Control of Inflammation and Pain
    Jasmine Ji, Aidan McGinnis, Ru‐Rong Ji · 2023 · Springer eBooks
  25. Körperliche Aktivität im Kontext Diabetes mellitus
    Christine Joisten · 2023 · Die Diabetologie
  26. Potential Value and Application of Liquid Biopsy in Tumor, Neurodegeneration, and Muscle Degenerative Diseases
    Lin Chen, Jun Yang, Guodong Xu, Yuxiang Wu · 2023 · Methods in molecular biology
  27. Role of the Glucocorticoid Receptor in Systemic Energy Metabolism
    Hirotoshi Tanaka, Noritada Yoshikawa, Hiroki Yamazaki, Masaaki Uehara, Aya Oda · 2018 · Nihon Naika Gakkai Zasshi
  28. The protective role of hydrogen sulfide on skeletal muscle in cast immobilization model of hindlimbs in rats
    Nehal Abdel -Halim, Shereen M. Samir, khaled ezam, Aya Abd El-Hamed, Soheir Helmy, Hanaa G. Elserougy · 2021 · Bulletin of Egyptian Society for Physiological Sciences
  29. Musculoskeletal Aging, Sarcopenia, and Cancer
    Matteo Cesari, Riccardo Calvani, Emanuele Marzetti · 2018 · Springer eBooks
  30. Obesity and Inflammatory Profile: Is Physical Exercise Able to Reverse This Process? A Mini Review
    2020
  31. Interactions Between Muscle and Bone
    Marco A. P. Brotto · 2018 · Primer on the metabolic bone diseases and disorders of mineral metabolism
  32. MOLECULAR GENETIC FACTORS OF THE SKELETAL MUSCLE HYPERTROPHY
    Svitlana Drozdovska, M. I. Kalinski · 2018 · Bulletin of Problems Biology and Medicine
  33. El músculo, paradigma metabólico en la recuperación nutricional
    Ángel Gil Hernández · 2019 · Nutrición Hospitalaria
  34. The Effects of Acute Exercise and Aging on the Growth of Prostate Cancer Cells
    Ji Hui Hwang · 2019 · Queensland University of Technology
  35. Genetic and epigenetic determinants of muscle mass
    MICHAEL I. KALINSKI, Svitlana Drozdovska · 2019 · Elsevier eBooks
  36. In July 2019 the Portuguese Society of Myology was officially born: the first message from the founders
    Paula Tavares, Carlos Ribeiro · 2019 · European Journal of Translational Myology
  37. From brain to muscle and back : novel approaches to harness the benefits of exercise
    Yildiz Kelahmetoglu · 2020 · Figshare
  38. Skeletal muscle weakness and mitochondrial dysfunction in the osteogenesis imperfecta murine (oim) model
    Victoria L. Gremminger · 2021
  39. Miopatía esquelética en la insuficiencia cardiaca. Implicación potencial de las miocinas
    Iñigo Latasa, Robinson Ramírez‐Vélez, Míkel Izquierdo, Javier Dı́ez · 2021 · Revista Española de Cardiología
  40. Irisin: A small myocin with a wide potential
    Hélida Maravilha Dantas e Sousa Almeida, Eder Almeida Freire, Letícia Carvalho Benitez, Luiz Gabriel Dias, Maria Laryssa Monte da Silveira, Rafaelle Cavalcante de Lira, Raquel Cavalcanti · 2021 · MOL2NET International Conference on Multidisciplinary Sciences (MOL2NET)
  41. Klotho, much more than an anti-aging protein, an emerging exerkine: A systematic review and meta-analysis
    Hugo de Luca Corrêa, Artur Temizio Oppelt Raab, Thamires Marra Araújo, Lysleine Alves Deus, Andrea Lucena Reis, Fernando Sousa Honorato, Paolo Lucas Rodrigues-Silva, Rodrigo Vanerson Passos Neves, Henver S. Brunetta, Marcelo Alves Silva Mori et al. · 2022 · Research Square
  42. Muscle Hormones
    Ana María Rodríguez, Maria Luisa Bonet, Joan Ribot · 2019 · Elsevier eBooks
  43. Establishing and Validating Methods to Assess the Influence of Exercise on Circulating Exosome Profiles in Sedentary Older Adults
    Heather D. Quiriarte · 2021
  44. Exercise serum regulate uric acid transporters in normal rat kidney cells
    Zhongye Jiang, Jianmin Cao, Hao Su, Hui Cao, Ze-Yuan Sun, Hao-Ze Jiang, Yan-Jun Fan · 2022 · Research Square
  45. Exercício físico e sistema purinérgico
    Hugo Falqueto, Jorge Lúcio Rodrigues Júnior, Andréia Machado Cardoso, Leandro Henrique Manfredi · 2021 · Editora UFFS eBooks
  46. EXERCINAS: NOVOS HORIZONTES NA BIOLOGIA DO EXERCÍCIO FÍSICO
    André Katayama Yamada · 2023 · Revista Brasileira de Ciência e Movimento
  47. Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel
    Tengteng Huang, Xiaoling Chen, Jun He, Ping Zheng, Yuheng Luo, Aimin Wu, Hui Yan, Bing Yu, Daiwen Chen, Zhiqing Huang · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Myokines, Measurement, and Technical Considerations
    Craig R. G. Willis, Colleen S. Deane, Timothy Etheridge · 2023 · Neuromethods
  49. Epigenetische Veränderungen in Zusammenhang mit Bewegungstherapie
    Moritz Carl Völker-Albert · 2023 · B&G Bewegungstherapie und Gesundheitssport
  50. THE PARTICIPATION OF IRISIN IN THE MECHANISMS OF WEIGHT LOSS IN OBESITY
    Yu. M. Panchenko, Svitlana Drozdovska · 2023 · Bulletin of Problems Biology and Medicine
  51. Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel
    Tengteng Huang, Xiaoling Chen, Jun He, Ping Zheng, Yuheng Luo, Aimin Wu, Hui Yan, Bing Yu, Daiwen Chen, Zhiqing Huang · 2023 · eLife
  52. Circadian Aspects of Skeletal Muscle Biology
    Julien Delezie, Katja A Lamia · 2024 · Royal Society of Chemistry eBooks
  53. Effects of Extreme Physical and Mental Load on Circulating Exerkines in Professional Athletes
    Roland Ligetvári · 2024
  54. Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel
    Tengteng Huang, Xiaoling Chen, Jun He, Ping Zheng, Yuheng Luo, Aimin Wu, Hui Yan, Bing Yu, Daiwen Chen, Zhiqing Huang · 2024 · eLife
  55. Physiological Mechanisms of Exercise Related to Prevention and Treatment of Breast Cancer: A review
    Maryam Koushkie Jahromi, Ahmadreza Dehghani, Mohammadhosein Ghasemi · 2024 · Archives of Breast Cancer
  56. The Potential Protective Mechanisms of Exercise-Responsive Molecules in Chronic Kidney Disease
    Jae Seung Chang · 2024 · Exercise Science
  57. The microRNA regulatory landscape of skeletal muscle-derived extracellular vesicles
    Yudai Kawamoto, Atomu Yamaguchi, Xiaoqi Ma, Hidemi Fujino, Noriaki Maeshige · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  58. In the Pursuit of Excellence—The Importance of Electrical Stimulation Modalities for Athletics
    Amir H. Pakravan · 2025 · Springer eBooks
  59. Loss of ovarian hormones modulates the nucleic acid content of circulating extracellular vesicles and skeletal muscle metabolism in response to acute exercise
    Veera Puumalainen, Anni Maja, Tia-Marje K. Korhonen, Tuuli A. Nissinen, Eero Hulkko, Janne A. Ihalainen, Maarit Lehti, Sira M. Karvinen · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  60. The value of fibroblast growth factor 21 in health and pathology
    Y. Akhverdyan, E. Papichev, B. V. Zavodovsky, Yu. V. Polyakova, L. E. Seewordova, Рожкова Екатерина Сергеевна · 2025 · Сибирский журнал клинической и экспериментальной медицины
  61. MUSTN1 prevents muscle atrophy through ferroptosis suppression: A ACO1-dependent and exosome-mediated mechanism
    Zhi Hu, Hengyong Xu, Xi Wang, Qingqing Deng, Jiahao Dai, Yuxiang Lu, Jiapeng Chen, Yiping Liu, Chaowu Yang, Mohan Qiu et al. · 2026 · International Journal of Biological Macromolecules
  62. Maintien de la fonction musculaire : Exercice en hémodialyse : rôles physiologiques de eIF3f
    Laura Pavlin · 2021 · theses.fr (ABES)
  63. Beyond GLP-1: underexplored peptide–receptor systems as the next frontier in drug discovery
    Sarfaraz K. Niazi · 2026 · Frontiers in Drug Discovery
  64. Anatomy and Function of the Skeletal Muscle, Skin, and Fascia
    Hyun-Yoon Ko · 2026 · Springer eBooks
  65. The interaction between exercise and autophagic flux in neurodegenerative muscleloss
    Dongdong Wang, Yahui Li · 2026 · Gene
  66. Imaging Biomarkers of Cognitive Impairment in Sarcopenia: A Narrative Review
    Wen-Xuan Lei, Jingjun Zhu, Yan-Ting Jiang, Xiaohan Peng, H Y Sun, Jia Tan, Xi-Hua Zhou, Mingxuan Huang, Hao Lei, Heng Zhao · 2026 · International Journal of General Medicine
  67. Unlocking Neuroprotection: Exercise-Induced Muscle Secretome (Myokines) as a Therapeutic Avenue Against Alzheimer’s Disease Pathogenesis
    Hossein Shirvani, Linda Shannon Pescatello, Ali Reza Eftekhari Moghadam, Ehsan Arabzadeh · 2026 · Journal of Molecular Neuroscience
  68. Exercise‐Induced Irisin Antagonizes TGFBR2 to Attenuate Islet Fibrosis and Improve Glucose Homeostasis in Type 2 Diabetes
    Qianqian Wang, Xiaohang Wang, Zhensheng Cai, Vladmir Carvalho, H F Wang, Yang Chen, Zilin Sun, Shanhu Qiu · 2026 · The FASEB Journal
  69. Autonomic Modulation and Body Composition in Educators: Physiological Associations in the Workplace Context
    Estela Álvarez-Gallardo, Andrea Calderón García, Pilar González Sanz, Pedro Belinchón-deMiguel, Vicente Javier Clemente‐Suárez · 2026 · Brain and Behavior
  70. CXCL2 is a modifiable driver of sarcopenic inflammation attenuated by exercise in older women: Integrated transcriptomic and experimental evidence
    Juyeon Lee, Sung-Wook Chun, Subin Choi, Jae Sook Kang, Seong Jun Park, Yong Ryoul Yang, Hwa‐Rim Lee, Kyung-Ha Lee · 2026 · Journal of sport and health science/Journal of Sport and Health Science
  71. Ovarian hormone loss modifies the nucleic acid cargo of circulating extracellular vesicles and skeletal muscle metabolism after acute exercise in rats
    Veera Puumalainen, Anni Maja, Tia-Marje K. Korhonen, Tuuli A. Nissinen, Eero Hulkko, Janne A. Ihalainen, Maarit Lehti, Sira M. Karvinen · 2026 · Experimental Physiology
  72. Exerkines in precision management of metabolic diseases
    Leigang Jin, Yifen Lin, Yixuan Zheng, Anli Wang, Peng Liao, Yucheng Luo, Zhongheng Sui, Xiayun Ni, Jianan Zhang, Qing Shen et al. · 2026 · Chinese Medical Journal
  73. Exercise-Induced Skeletal Muscle Secretory Factors and Macrophage Functional Remodeling: Mechanistic Advances
    Zi-Yang Li, Chen-Yu Lin, Lin-Tao Tang, Yi-Yao Xu, Jie-Ming Liang, De-Hui Pan, Zi-Shuai Huang, Xian-Yan Xie, Yu Wang, Shu-Qi Qin et al. · 2026 · International Journal of Molecular Sciences
  74. The Myokine Landscape: Sources, Signaling, and Context-Dependent Actions
    Carme Casadevall, Alba Ramírez-Sarmiento, Ramon Camps-Ubach, Esther Barreiro, Mauricio Orozco‐Levi, Joaquim Gea · 2026 · Cells
  75. Exerkines in Cardiovascular–Kidney–Metabolic Syndrome: An Integrative Framework for Mechanisms and Therapeutic Implications—A Narrative Review
    Hongyan Fan, Changlin Zhai, Chao‐Jie He, Liang Shen, H. Y. Pan, Wenwen Zheng · 2026 · Reviews in Cardiovascular Medicine
  76. Chemotherapy‐Induced Skeletal Muscle Dysfunction and Cognitive Impairment: A Muscle‐Brain Mechanistic Framework With Implications for Exercise Oncology
    SoYoung Ahn, Jin‐Soo Kim, Daniel Abido Galvao, Dennis R. Taaffe, Dong Hyun Yoon, Carolyn J. Peddle‐McIntyre, Christelle Schofield, Yoon Jung Chang, Jihee Min, Wook Jae Song et al. · 2026 · Journal of Cachexia Sarcopenia and Muscle
  77. Could a skeletal-muscle phosphatidic acid–organelle stress–Secretome Axis promote atherosclerosis? AGPAT1 as a candidate upstream enzyme
    Man Liao, Xuemei Li · 2026 · Medical Hypotheses
  78. Creatine and essential amino acids with exercise in obesity: an immunometabolic perspective on the muscle–adipose–brain axis
    Yongjun Zhao, Juan Zhao, Congcong Xie, Xuxia Yang, 李建英 · 2026 · Frontiers in Immunology
  79. Muscle-derived insulin-like growth factor I cannot compensate for global Igf1 deficiency in mice
    J.K. Armstrong, Alan L. Grant, P.V. Malven, W. Muir, D E Gerrard · 2026 · General and Comparative Endocrinology