Targeting iron metabolism in drug discovery and delivery

Crielaard, Bart J., Lammers, Twan, Rivella, Stefano·2017·Nature Reviews Drug Discovery
DOI 10.1038/nrd.2016.248

Cited by (353)

Items 301–353 of 353

  1. Alternative splicing in breast cancer
    Xin Wen, Ze Yan, Sha Li · 2023 · Journal of Bio-X Research
  2. Mitochondrial Alterations Mediated by Exposure to Environmental Pollutants
    Lada V. Shabardina, Yuliya Vladimirovna Ryabova, Vlada A. Bateneva, Ilzira Amirovna Minigalieva · 2025 · I P Pavlov Russian Medical Biological Herald
  3. Adverse pulmonary effects and metallic characteristic of size-resolved welding fumes in human lung epithelial BEAS-2B cells
    Pin-Hao Qiu, Chia‐Hua Lin, Yen-Ping Peng, Ku‐Fan Chen, Yi‐Chun Chen, Yung‐Chang Lin, Chia-Hsiang Lai · 2025 · Environmental Toxicology and Pharmacology
  4. In Silico Identification of Bioactive Peptides from Amaranthus Globulin Protein for Enhancement of Iron Absorption: A Food Science Perspective
    Naman Kaur, Simran Kaur, Chandraket Kumar, Gitanjali Tandon, Sarika Jaiswal, Aparna Agarwal, Manisha Sabharwal, Mir Asif Iquebal, Abhishek Dutt Tripathi · 2025 · Food Biotechnology
  5. Osteosarcoma cells promote intracellular iron detoxification to mitigate GPX4-mediated ferroptosis
    Md Abdullah, Donghee Lee, Eslenur Nipa, Jessy Castellanos-Gell, Ann M. Chan, Oscar Hernandez Maldonado, Marc E. Salute, Rebecca Nance-Richey, Rowan J. Milner, Jong Hyuk Kim · 2026 · Cancer Gene Therapy
  6. Vestibular evoked myogenic potentials in patients with iron deficiency anaemia
    Fatma Atalay, Murat Yaşar, Tuba Uyanık, Sezai Sacid Anbar · 2026 · Acta Otorhinolaryngologica Italica
  7. The Role of Iron in Adipose Tissue Function, Crosstalk, and Transdifferentiation
    Jiamin Guo, Panpan Yu, 李陈康, 聂桂英, Wenchen Xu, Meiyi Chen, Liang Li, Tianhong Peng, Wei Xie · 2026 · Cell Biochemistry and Function
  8. Transferrin-functionalized liposomes for targeted breast cancer therapy: Mechanistic insights, conjugation strategies, and translational evidence
    Loganathan Chandramani Priya Dharshini, Abul Kalam Azad Mandal · 2026 · Biomedicine & Pharmacotherapy
  9. Experience with the prolonged release of iron in iron deficiency patients
    Vladimir N. Drozdov, Е. В. Ших, A. A. Astapovskii, Цветков Дмитрий Николаевич · 2023 · Meditsinskiy sovet = Medical Council
  10. CRYO-EM AND SLC TRANSPORTERS
    Joshua A. Lees, Seungil Han · 2022 · Medicinal chemistry reviews
  11. Unraveling the binding mechanism of olanzapine with human serum transferrin: a multispectroscopic and computational investigation
    Aleksandar Djurović, Emina Mrkalić, Žiko Milanović, Marina Ćendić Serafinović, Jadranka Odović, Dragan R Milovanovic, Ratomir Jelić · 2025 · Molecular Diversity
  12. Spurenelemente
    Martina Ulrike Muckenthaler, Petro E. Petrides · 2022 · Springer eBooks
  13. A Novel Colorimetric and Fluorescent Dual-Signals Probe Based on Rhodamine B and Tripeptide for Highly Sensitive Detection of Trivalent Ions and its Application in Living Cells Imaging
    Peng Wang, Weiliang Deng, Qifan Wang, Shirui Xue · 2023 · SSRN Electronic Journal
  14. Sepsis: Staging and Potential Future Therapies
    Christine Lehmann, Juan Zhou, Charles C. Caldwell · 2017 · Colloquium Series on Integrated Systems Physiology From Molecule to Function
  15. Multiple Modes of Hepcidin Regulation in Breast Cancer
    Nicole Farra · 2017 · OpenCommons - UConn (University of Connecticut)
  16. Nano‐sensing and nano‐therapy targeting central players in iron homeostasis
    Linyuan Wu, Yan Li, Ning Gu · 2020 · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
  17. Iron metabolism as a novel therapeutic target
    Paul J. Farrell · 2021 · Blood
  18. Epigenetic upregulation by valproic acid of transferrin receptor 1, and not glucose transporter 1 or CD98hc, at the blood-brain barrier
    Steinunn Sara Helgudóttir, Kasper Bendix Johnsen, Lisa Greve Routhe, Charlotte Laurfelt Munch Rasmussen, Azra Karamehmedovic, Maj Schneider Thomsen, Torben Moos · 2022 · Research Square
  19. The Influence and Prognostic Value of Iron Metabolic-Related Gene Signatures in Hepatocellular Carcinoma Patients
    凤 张 · 2021 · Advances in Clinical Medicine
  20. Developing New Cancer Nanomedicines by Repurposing Old Drugs
    Bowen Yang, Jianlin Shi · 2020 · Angewandte Chemie
  21. Faculty Opinions recommendation of Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.
    Navdeep S. Chandel · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  22. Iron Deficiency in Heart Failure: What Do We Know So Far?
    Amr Elkammash, Rasha M Farahat, Aya Al Sattouf, Julius Lenaerts, Khin Yadanar Maung, Aayesha Khatri · 2022 · Cureus
  23. FGFR1 governs iron metabolism via regulating post-translational modification of IRP2 in prostate cancer cells
    Hui Lin, Liuhong Shi, Dongyan Zhou, Shuangya Chen, Ping He, Xiaolu Zheng, Feng Xian Qiu, Yuying Yuan, Shuaijun Lin, Xiaokun Li et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  24. Research Progress in Iron Metabolism in Heart Failure
    航 赵 · 2023 · Advances in Clinical Medicine
  25. Data from Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11
    Xinbo Wang, Yueqing Chen, Xudong Wang, Hongling Tian, Yanjin Wang, Jiali Jin, Zezhi Shan, Yue Liu, Zhenyu Cai, Xinyuan Tong et al. · 2023
  26. การเปรยบเทยบประสทธภาพระหวางการใหธาตเหลกทดแทนแบบวนเวนวน กบการใหธาตเหลกทกวนในการรกษาภาวะโลหตจางในหญงวยเจรญพนธ
    ศศินิภา ตรีทิเพนทร์ · 2020
  27. Introduction to metalloenzymes: From bench to bedside
    William A. Donald, Claudiu Trandafir Supuran · 2023 · Elsevier eBooks
  28. The Role of Autophagy in Ferroptosis
    Rui Kang, Daolin Tang · 2023 · Springer eBooks
  29. Mechanisms of Iron Deficiency in Obese Children
    Xin-yan Yan · 2023 · Clinical Medicine Research
  30. Ferritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells
    Clément Larrue, Sarah Mouche, Paolo Angelino, Maxime Sajot, Rudy Birsen, François Vergez, Christian Récher, Véronique Mansat‐De Mas, Qiong Gu, Jun Xu et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Oxidative stress induces ferroptosis in tendon stem cells by regulating mitophagy through cGAS-STING pathway during tendinopathy
    Shizhong Zheng, yuanyuan gao, Wenshuang Sun, junrui Wang, danli Zhao, haoyuan Tian, yangling Qiu, Shufan Ji, shuqi Wang, qiuyu Fu et al. · 2024 · Research Square
  32. Semmelweis Egyetem Iron Board – Vaspótlás-konszenzusdokumentum
    Emese Csulak, Bálint Gellért, István Hritz, Pál Miheller, Péter Farkas, Gábor Kovács, Attila Jozsef Szabo, Nándor Ács, David J Becker, Nóra Sydó et al. · 2024 · Orvosi Hetilap
  33. Research Advances in Ferroptosis in Ovarian Cancer: From Mechanism to Therapy
    柳青 张 · 2025 · Advances in Clinical Medicine
  34. Application of mesenchymal stem cells in ferroptosis-related diseases
    Xianmei Zhong, Xue Zhang, Yuxuan Zhu, Xi Zheng · 2025 · Journal of Molecular Medicine
  35. Additional file 4 of SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain
    Liu, Yanqun, Rong Xiong, Xiao, Ting, Xiong, Li, Wu, Jialin, Li, Junfeng, Gang Feng, 宋桂芹, Kang Liu · 2023 · Figshare
  36. Additional file 1 of SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain
    Liu, Yanqun, Rong Xiong, Xiao, Ting, Xiong, Li, Wu, Jialin, Li, Junfeng, Gang Feng, 宋桂芹, Liu, Kang · 2023 · Figshare
  37. Additional file 2 of SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain
    Liu, Yanqun, Rong Xiong, Xiao, Ting, Xiong, Li, Wu, Jialin, Li, Junfeng, Gang Feng, 宋桂芹, Liu, Kang · 2023 · Figshare
  38. Additional file 1 of Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer
    Jieon Hwang, Areum Park, Chinwoo Kim, Kim, Chang Gon, Jaesung Kwak, Byungil Kim, Shin, Hyunjin, Minhee Ku, Yang, Jaemoon, Baek, Ayoung et al. · 2024 · Figshare
  39. Additional file 3 of SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain
    Liu, Yanqun, Rong Xiong, Xiao, Ting, Xiong, Li, Wu, Jialin, Li, Junfeng, Gang Feng, 宋桂芹, Kang Liu · 2023 · Figshare
  40. Metformin-amplified ferroptosis induced by ultrasmall manganese ferrite nanoparticles: a GPX4-independent strategy for prostate cancer therapy
    Zitong Li, Wei Zhang, Yanjun Xu, Weijuan Zou, Tongtong Nie, Jianrong Wu, Lei Chen, Zheying Meng · 2025 · Journal of Nanobiotechnology
  41. Immunometabolic Responses upon Bacterial Infections
    Vijay Soni, Aditya Upadhyay · 2026 · Springer eBooks
  42. TF-TfR1 axis: Roles in antibacterial immunity and intestinal stability in teleost fish
    Liangliang Mu, Qingliang Zeng, Peiyu Li, Hao Bai, Nuo Chen, Lingyuan Zeng, Jianmin Ye, Xiaoxue Yin · 2026 · Aquaculture
  43. Ferritin in motion: How systemic iron balance and tumor trafficking shape glioblastoma
    Emily Tufano, James R. Connor · 2026 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  44. The crosstalk between iron metabolism and immune tolerance in autoimmunity
    Fatemeh Tavassoli Razavi, Esmaeil Yazdanpanah, Alireza Shadab, Atena Sarmasti Emami, Dariush Haghmorad · 2026 · Inflammation Research
  45. Systemic iron availability differentially shapes tumor and brain iron handling in a sex-dependent manner in glioblastoma
    Emily Tufano, Kondaiah Palsa, Rebecka O. Serpa, Timothy B. Helmuth, Gabriela Remite-Berthet, Sara L. Mills-Huffnagle, Mathias Kant, Swetapadma Sahu, James R. Connor · 2026 · PLoS ONE
  46. ALDH1a3 Protects Against Iron Overload−Induced Oxidative Stress and Mitochondrial Impairment in Renal Tubular Epithelial Cells
    Tingting Wei, Zongliang Xiong, Tianci Wang, Chao Huang, Qihui Luo, Riyi Shi, Lanlan Jia, Wentao Liu, Donghui Yang, Zhengli Chen · 2026 · Antioxidants
  47. Closed-loop iron chelate recycling via molecularly imprinted hydrogels suppresses ferroptosis
    Yubin Yao, Ting Ying, Chenyu Zong, Tao Ding, Qi Li, Zeyu Han, Fang Wang, Wenguo Cui, Mingzhu Zhang · 2026 · Nature Communications
  48. Semiautomated Volumetric Hemorrhage Quantification Using High-Frequency Ultrasound Following Spinal Cord Injury
    Aysha Allard Brown, Kitty So, Juliana Mitchell, Neda Manouchehri, Megan Webster, Jay Ethridge, Audrey Warner, Avril Billingsley, Rochelle Newsome, Jing Wang et al. · 2026 · Journal of Neurotrauma
  49. Exploring Ferroptosis: A Key Mechanism in Respiratory System Diseases and its Therapeutic Potential
    Zhongyu Han, 谢秀丽, Haoran Chen, Ling Ding, Ruimin Yuan, Mingyu Huang, Lan Yuan, Yaru Wang · 2026 · Applied Biochemistry and Biotechnology
  50. GTP-binding protein DIRAS2 inhibits ferroptosis in oral leukoplakia via regulating iron metabolism
    Zitong Tian, Xing Li, Anyi Wang, Wenjing Li, Min Wang, Xiaofei Tang, Min Zhang · 2026 · European Journal of Cell Biology
  51. Ferroptosis in kidney disease
    Tianyi Wang, Shumin Sun, Andreas Linkermann, Junxia Min, Fudi Wang · 2026 · Nature Reviews Nephrology
  52. Efficacy Augmentation of Ferroptosis-Inducing Nanomedicine for Tyrosine Kinase Inhibitor-Resistant Lung Cancer Brain Metastasis
    Youming Zeng, Chenyu Lin, Jiahui Yang, Minjie Fu, Jiadong Ma, Lan Mo, Huang Yang, Xiaohui Li, Cheng Li, Rui Zeng et al. · 2026 · ACS Nano
  53. BindingDB Entry 50012329: Hydroxypyridinone-Based Iron Chelators with Broad-Ranging Biological Activities.
    BindingDB · 2022 · UC San Diego