Targeting iron metabolism in drug discovery and delivery

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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Ferroptosis as a p53-mediated activity during tumour suppression

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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LXXIII.—Oxidation of tartaric acid in presence of iron

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Cloning and characterization of a mammalian proton-coupled metal-ion transporter

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Protein Oxidation and Aging

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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

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A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549 · see citing works

The role of iron and reactive oxygen species in cell death

Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1416 · Cited by 2,381 · see citing works

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168 · see citing works

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W., & Kimmelman, A. C. (2014) · Nature · doi:10.1038/nature13148 · Cited by 2,084 · see citing works

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

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Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., & Aderem, A. (2004) · Nature · doi:10.1038/nature03104 · Cited by 1,877 · see citing works

The role of iron in brain ageing and neurodegenerative disorders

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Impact of epoetin alfa on clinical end points in patients with chronic renal failure: A meta-analysis

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M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

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Identification of the haemoglobin scavenger receptor

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Iron-Deficiency Anemia

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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

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Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

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Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

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Iron and cancer: more ore to be mined

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Oxidation of tartaric acid in presence of iron

Fenton, H. J. H. (1894) · Journal of the Chemical Society (Resumed) · Cited by 1,498 · see citing works

A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

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Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis

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LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

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Oxidative stress inhibits distant metastasis by human melanoma cells

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A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( <i>USF2</i> ) knockout mice

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pH and the recycling of transferrin during receptor-mediated endocytosis.

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Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

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Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146 · see citing works

Identification of erythroferrone as an erythroid regulator of iron metabolism

Kautz, L., Jung, G., Valore, E. V., Rivella, S., Nemeth, E., & Ganz, T. (2014) · Nature Genetics · doi:10.1038/ng.2996 · Cited by 1,127 · see citing works

Synchronized renal tubular cell death involves ferroptosis

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Systemic Iron Homeostasis

Ganz, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2013 · Cited by 1,122 · see citing works

Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine.

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An iron-regulated ferric reductase associated with the absorption of dietary iron

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An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

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Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

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Protein oxidation and aging

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Bacterial Iron Sources: From Siderophores to Hemophores

Wandersman, C., & Delepelaire, P. (2004) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123811 · Cited by 1,056 · see citing works

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

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Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

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Heme oxygenase 1 is required for mammalian iron reutilization

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Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

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<i>Nramp</i> <i>2</i> is mutated in the anemic Belgrade ( <i>b</i> ) rat: Evidence of a role for Nramp2 in endosomal iron transport

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Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

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Iron homeostasis in host defence and inflammation

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The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22

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Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

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Intramuscular desferrioxamine in patients with Alzheimer's disease

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The Steap proteins are metalloreductases

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Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

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Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs.

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HSPB1 as a novel regulator of ferroptotic cancer cell death

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TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord

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Hexameric Structure and Assembly of the Interleukin-6/IL-6 α-Receptor/gp130 Complex

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Molecular Cloning of Transferrin Receptor 2

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Macrophage subsets in atherosclerosis

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Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)

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Regulated necrosis: disease relevance and therapeutic opportunities

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Mitoferrin is essential for erythroid iron assimilation

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Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

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The Biochemistry of Desferrioxamine and its Relation to Iron Metabolism

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LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation

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Stoichiometric and site characteristics of the binding of iron to human transferrin

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The Molecular Mechanism of Action of Artemisinin—The Debate Continues

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Lack of the bone morphogenetic protein BMP6 induces massive iron overload

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The serine protease TMPRSS6 is required to sense iron deficiency

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Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells

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Transferrin receptor is necessary for development of erythrocytes and the nervous system

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Binding and uptake of H-ferritin are mediated by human transferrin receptor-1

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Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene

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The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

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Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene

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Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

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The biology and chemistry of high-valent iron–oxo and iron–nitrido complexes

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Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

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�ber die Katalyse des Hydroperoxydes

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