Targeting iron metabolism in drug discovery and delivery

Cited by (353)

Items 201–300 of 353

1. Iron, Ferroptosis, and Head and Neck Cancer
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2. Modulation of Metal Homeostasis for Cancer Therapy
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3. Iron-related Biomarkers in the Diagnosis and Management of Iron Disorders
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4. Chinese food seasoning derived carbon dots for highly selective detection of Fe3+ and smartphone-based dual-color fluorescence ratiometric visualization sensing
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5. Carnosine supplementation reduces plasma soluble transferrin receptor in healthy overweight or obese individuals: a pilot randomised trial
   Estifanos Baye, Jozef Ukropec, Maximilian de Courten, Tímea Kurdiová, Patrik Krumpolec, José Manuel Fernández‐Real, Giancarlo Aldini, Barbara Ukropcová, Barbora Vozarova de Courten · 2018 · Amino Acids
6. The Structural Basis for Metal Ion Transport in the SLC11/NRAMP Family
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7. A Ubiquitin‐Competitive Strategy Based on the Element Microenvironment to Treat Osteoarthritis
   Keyu Kong, Yuqi Yang, Yongyun Chang, Youdong Chen, Xiao Q. Yang, Jiahao Qin, Zhuorun Song, Shunyi Lu, Zanjing Zhai, Jun Ge et al. · 2024 · Advanced Functional Materials
8. Coatable tannic acid-deposited cellulose nanocrystals for Fe(III) sensing and its application to a facile, scalable and portable sensing platform
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9. Identification of a Novel Inhibitor of TfR1 from Designed and Synthesized Muriceidine A Derivatives
   Yu Wu, Zongchen Ma, Xiaoyuan Mai, Xiaoling Liu, Pinglin Li, Xin Qi, Guoqiang Li, Jing Li · 2022 · Antioxidants
10. The influence of female mice age on biodistribution and biocompatibility of citrate-coated magnetic nanoparticles
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11. Iron metabolism disorder regulated by BMP signaling in hypoxic pulmonary hypertension
    Yujie Jiang, Yingfan Guo, Xuexiang Feng, Pingting Yang, Yi Liu, Xuejing Dai, Feilong Zhao, Dongyu Lei, Xiaohui Li, Yuan Liu et al. · 2022 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
12. Albumin Conjugates of Thiosemicarbazone and Imidazole‐2‐thione Prochelators: Iron Coordination and Antiproliferative Activity
    Yu‐Shien Sung, Wangbin Wu, Megan A. Ewbank, Rachel D. Utterback, Michael Thomas Marty, Elisa Tomat · 2021 · ChemMedChem
13. Ferritin in Acute Myeloid Leukemia: Not Only a Marker of Inflammation and Iron Overload, but Also a Regulator of Cellular Iron Metabolism, Signaling and Communication
    Håkon Reikvam, Magnus Gramstad Rolfsnes, Linn Åsholt Rolsdorph, Miriam Sandnes, Frode Selheim, Maria Hernandez-Valladares, Øystein Bruserud · 2025 · International Journal of Molecular Sciences
14. A macrocyclic molecule with multiple antioxidative activities protects the lens from oxidative damage
    Jinmin Zhang, Yu Yu, Magy A. Mekhail, Hongli Wu, Kayla N. Green · 2022 · Frontiers in Chemistry
15. A fluorescent nanoprobe and paper-based nanofiber platform for detection and imaging of Fe3+ in actual samples and living cells
    Ning Ding, Ruoqing Liu, Bo Zhang, Ningru Yang, Mingwei Qin, Yin Zhang, Zhouping Wang · 2024 · Talanta
16. Pharmacokinetics, pharmacodynamics, and tolerability of an aqueous formulation of rusfertide ( PTG ‐300), a hepcidin mimetic, in healthy volunteers: A double‐blind first‐in‐human study
    Nishit B. Modi, Richard S. Shames, Jason D. Lickliter, Suneel Gupta · 2024 · European Journal Of Haematology
17. Glioblastoma mesenchymal subtype enhances antioxidant defence to reduce susceptibility to ferroptosis
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18. Design, Synthesis, and Anticancer Activity of Drug-like Iron Chelators/G-Quadruplex Binders as Synergic Dual Targeting Agents
    Marialuisa Piccolo, Camilla Russo, Valentina Arciuolo, Maria Grazia Ferraro, Vincenzo Abbate, Anna Di Porzio, Elpidio Cinquegrana, Francesco Saverio Di Leva, Bruno Pagano, Antonio Randazzo et al. · 2025 · Journal of Medicinal Chemistry
19. Chromene–triazole-pyrimidine based chemosensor therapeutics for the in vivo and in vitro detection of Fe 3+ ions
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20. Influence of mitochondrial and systemic iron levels in heart failure pathology
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21. Unraveling Hepcidin Plasma Protein Binding: Evidence from Peritoneal Equilibration Testing
    Diepeveen, Laura E., Laarakkers, Coby M., Peters, Hilde P.E., van Herwaarden, Antonius E., Groenewoud, Hans, IntHout, Joanna, Wetzels, Jack F., van Swelm, Rachel P.L., Swinkels, Dorine W. · 2019 · Pharmaceuticals
22. Fe3+-DOX-mediated self-assembled nanolipids for tumor microenvironment activated synergistic ferroptotic-chemo therapy assisted with MR-imaging
    Changyu Cao, Guangxiang Si, Nan Yang, Wenjun Wang, Zheye Zhang, Fengchao Zang, Xuejiao Song, Peng Chen, Xiaochen Dong · 2024 · Sensors and Actuators B Chemical
23. Nanovesicle-templated nanogel: A dual-modal platform integrating intracellular iron homeostasis disruption for ferroptosis and MRI-guided tumor diagnosis
    Jicheng Jiang, Yan Shen Peng, Liyan Qiu · 2024 · Chemical Engineering Journal
24. From detection to elimination: iron-based nanomaterials driving tumor imaging and advanced therapies
    Dong Xie, Linglin Sun, Manxiang Wu, Qiang Li · 2025 · Frontiers in Oncology
25. General chemistry of metals, sampling, analytical methods, and speciation
    Donald R. Smith, Michael J. Maroney, Monica Nordberg, Julian F. Tyson · 2022 · Elsevier eBooks
26. 12 T high static magnetic field suppresses osteosarcoma cells proliferation by regulating intracellular ROS and iron status
    Shenghang Wang, Ting Huyan, Chenge Lou, Peng Shang, Hao Zhang · 2022 · Experimental Cell Research
27. Evaluation of the iron regulatory protein-1 interactome
    Gregory J. Connell, Jando S. Danial, Christian X. Haastruthers · 2018 · BioMetals
28. Tip60/Kat5 may be a novel candidate histone acetyltransferase for the regulation of liver iron localization via acetylation
    Nurdan Gönül Baltacı, Emine Toraman, Mesut Akyüz, Şeyda Nur Kalın, Harun Budak · 2022 · BioMetals
29. Research progress and perspective of metallic implant biomaterials for craniomaxillofacial surgeries
    Huafang Li, Jiaqi Hao, Xiwei Liu · 2024 · Biomaterials Science
30. Ferrous Iron Metabolism Modulator for Immune Stress Regulation and Its Application in Skin Allograft Models
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31. H4HBEDpa: Octadentate Chelate after A. E. Martell
    Neha Choudhary, Hayden Scheiber, Jiale Zhang, Brian O. Patrick, María de Guadalupe Jaraquemada-Peláez, Chris Orvig · 2021 · Inorganic Chemistry
32. Ferritin nanocage-enabled detection of pathological tau in living human retinal cells
    Lorenzo Barolo, Ylenia Gigante, Lorenza Mautone, Silvia Ghirga, Alessandro Soloperto, Alessandra Giorgi, Francesca Ghirga, Martina Pitea, Alessio Incocciati, Francesco Mura et al. · 2024 · Scientific Reports
33. Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells
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34. Iron deficiency in patients of heart failure with reduced ejection fraction
    Balbir Bagicha Singh, Nitin Bajaj, Priyanka Singh, Arijit Kumar Ghosh, R Anathakrishnan, Navreet Singh · 2022 · Medical Journal Armed Forces India
35. New Insights into the Physiology of Iron Transport: An Interdisciplinary Approach
    Jonas Zaugg, Jonai Pujol‐Giménez, Romina Silvia Cabra, Willy Hofstetter, Matthias A. Hediger, Christiane Albrecht · 2022 · CHIMIA International Journal for Chemistry
36. Hinokitiol protects gastric injury from ethanol exposure via its iron sequestration capacity
    Mengran Zhao, Chen Qiao, Shuyue Yang, Yefeng Tang, Wenjing Sun, Shanshan Sun, Qingdong Guo, Feng Du, Nan Zhang, Tingting Ning et al. · 2024 · European Journal of Pharmacology
37. New orphan disease therapies from the proteome of industrial plasma processing waste- a treatment for aceruloplasminemia
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38. Caffeine Decreases Hepcidin Expression to Alleviate Aberrant Iron Metabolism under Inflammation by Regulating the IL-6/STAT3 Pathway
    Zhongda Li, Meng-Yu Geng, Song-Rui Dou, Xuan Wang, Zi‐Han Zhang, Yan‐Zhong Chang · 2022 · Life
39. Mitochondrial Dysfunction and Risk Factors for Noncommunicable Diseases: From Basic Concepts to Future Prospective
    Ганна Володимирівна Невойт, Gediminas Jaruševičius, Maksim Potyazhenko, Ozar P. Mintser, Inga Arūnė Bumblytė, Alfonsas Vainoras · 2024 · Diseases
40. Effects of iron overload in human joint tissue explant cultures and animal models
    Indira Prasadam, Karsten Schrobback, Bastian Kranz-Rudolph, Nadine Fischer, Yogita Sonar, Antonia RuJia Sun, Eriza S. Secondes, Travis Jacob Klein, Ross Crawford, V. Nathan Subramaniam et al. · 2024 · Journal of Molecular Medicine
41. Doxorubicin‐Induced Cardiotoxicity: Comprehensive Pathway Insights and Advanced Preclinical Therapeutics
    Seema Sharma, Megha Parashar, Kanhaiya Lal, Manoj Naik, Sampat Singh Tanwar · 2026 · Journal of Applied Toxicology
42. Upregulation of Transferrin Receptor 1 (TfR1) but Not Glucose Transporter 1 (GLUT1) or CD98hc at the Blood–Brain Barrier in Response to Valproic Acid
    Steinunn Sara Helgudóttir, Kasper Bendix Johnsen, Lisa Greve Routhe, Charlotte Laurfelt Munch Rasmussen, Azra Karamehmedovic, Maj Schneider Thomsen, Torben Moos · 2024 · Cells
43. Iron metabolism dysfunction in neuropsychiatric disorders: Implications for therapeutic intervention
    Eduardo Pereira Duarte-Silva, Michael H. J. Maes, Christina Alves Peixoto · 2024 · Behavioural Brain Research
44. Potential of Application of Iron Chelating Agents in Ophthalmic Diseases
    Alireza Ghaffarieh, Joseph B. Ciolino · 2021 · Seminars in Ophthalmology
45. Iron Chelation Remits Memory Deficits Caused by the High-Fat Diet in a Mouse Model of Alzheimer’s Disease
    Yifan Xiao, Xiaokang Gong, Ronghua Deng, Wei Liu, Youhua Yang, Xiaochuan Wang, Jianzhi Wang, Jian Bao, Xiji Shu · 2022 · Journal of Alzheimer s Disease
46. Dietary Cottonseed Protein Substituting Fish Meal Induces Hepatic Ferroptosis Through SIRT1-YAP-TRFC Axis in Micropterus salmoides: Implications for Inflammatory Regulation and Liver Health
    Quanquan Cao, Ju Zhao, Xuefei Zhang, Laia Ribas, Haifeng Liu, Jun Jiang · 2025 · Biology
47. Pan-cell death-related signature reveals tumor immune microenvironment and optimizes personalized therapy alternations in lung adenocarcinoma
    Linzhi Han, Jingyi He, Hongxin Xie, Yan Qing Gong, Conghua Xie · 2024 · Scientific Reports
48. Synthesis and evaluation of a class of 1,4,7-triazacyclononane derivatives as iron depletion antitumor agents
    Sheng Wang, Yongkang Gai, Shasha Zhang, Lei Ke, Xiang Ma, Guangya Xiang · 2017 · Bioorganic & Medicinal Chemistry Letters
49. Mammary Leukocyte‐Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery
    Jie Cai, Jie Peng, Xinwei Zang, Juan Feng, Ruocheng Li, Peng Ren, Bingzhu Zheng, Jiaying Wang, Juan Wang, Mi Yan et al. · 2022 · Advanced Science
50. Iron Complexes of an Antiproliferative Aroyl Hydrazone: Characterization of Three Protonation States by Electron Paramagnetic Resonance Methods
    Andrei V. Astashkin, Rachel D. Utterback, Yu‐Shien Sung, Elisa Tomat · 2020 · Inorganic Chemistry
51. Association between the pre-transplantation serum ferritin level and outcomes of hematopoietic stem cell transplantation: A systematic review and meta-analysis
    Wenjue Pan, Qibei Teng, Huiqiao Chen, Liangning Hu, Xiaoyan Yue, Zijun Qian, Ruoyu Dong, Hongyu Zhou, Xiujie Zhao, Haowen Xiao et al. · 2024 · Heliyon
52. Iron-Mediated Overexpression of Amyloid Precursor Protein via Iron Responsive mRNA in Alzheimer’s Disease
    Mateen A. Khan · 2025 · International Journal of Molecular Sciences
53. Can Iron Play a Crucial Role in Maintaining Cardiovascular Health in the 21st Century?
    Michał Szklarz, Katarzyna Gontarz-Nowak, Wojciech Matuszewski, Elżbieta Maria Bandurska-Stankiewicz · 2022 · International Journal of Environmental Research and Public Health
54. Iron metabolism-related genes reveal predictive value of acute coronary syndrome
    Cong Xu, Wanyang Li, Tangzhiming Li, Jie Xin Yuan, Xinli Pang, Tao Liu, Benhui Liang, Lixin Cheng, Xin Sun, Shaohong Dong · 2022 · Frontiers in Pharmacology
55. Iron Deficiency in Heart Failure
    Ewa Anita Jankowska, Marcin Drozd, Piotr P. Ponikowski · 2016 · Springer eBooks
56. Thiol-Reactive Arylsulfonate Masks for Phenolate Donors in Antiproliferative Iron Prochelators
    Wangbin Wu, Yu‐Shien Sung, Elisa Tomat · 2022 · Inorganic Chemistry
57. A colorimetric and fluorescent dual-signals probe based on Rhodamine B and tripeptide for highly sensitive detection of trivalent ions and its application in living cells imaging
    Weiliang Deng, Qifan Wang, Shirui Xue, Peng Wang · 2023 · Journal of Photochemistry and Photobiology A Chemistry
58. Antagonistic Iron Competition Induced by Iron Chelators Heightens Cuproptosis in Both Tumors and Intratumoral Bacteria
    Yulin Xie, Junrong Wang, Yubin Han, Guo‐Qing Zhu, Chunxia Li, Qian-Qian Sun, Chunxia Li · 2025 · Advanced Materials
59. Ferroptosis in microglial activation: a systematic review and multidata comparison
    Ida Pesämaa, Srinivas Koutarapu, Henrik Zetterberg, Stefanie Fruhwürth · 2026 · Brain Communications
60. Sequence, Expression, and Anti-GCRV Function of the Ferritin from the Grass Carp, Ctenopharyngodon idellus
    Tiaoyi Xiao, Dongfang Li, Hao Tang, Yijing Liao, Jun Zou, Yaoguo Li · 2022 · International Journal of Molecular Sciences
61. Efficacy and safety of roxadustat for the treatment of anemia in non-dialysis chronic kidney disease patients: A systematic review and meta-analysis of randomized double-blind controlled clinical trials
    Ting Chen, Junyue Huang, Hui Dong, Lili Xu, Caihe Chen, Yu Tang, Wenhui Huang · 2022 · Frontiers in Nutrition
62. Asparagine starvation suppresses histone demethylation through iron depletion
    Jie Jiang, Sankalp Srivastava, Sheng Liu, Gretchen L. Seim, Rodney Claude, Minghua Zhong, Sha Cao, Utpal P. Davé, Reuben Kapur, Amber L. Mosley et al. · 2023 · iScience
63. Mining gene expression data for rational identification of novel drug targets and vaccine candidates against the cattle tick, Rhipicephalus microplus
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64. p38γ modulates ferroptosis in brain injury caused by ethanol and cerebral ischemia/reperfusion by regulating the p53/SLC7A11 signaling pathway
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65. Ascorbate and Tumor Cell Iron Metabolism: The Evolving Story and Its Link to Pathology
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66. Systemic and local hepcidin as emerging and important peptides in renal homeostasis and pathology
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67. Regulation and Function of Autophagy During Ferroptosis
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68. The mechanism of electroacupuncture-mediated improvement in Parkinson’s disease by inhibiting ferroptosis through activating the Nrf2/GPX4 signal pathway
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69. Multimodal Profiling of Iron Heterogeneity at the Nanoscale
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70. Metformin and its Nanoformulations in Cancer Prevention and Therapy
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71. Nanomedicine-mediated macrophage polarization enhances the iron-depleting effect of desferrioxamine for breast cancer immunotherapy
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72. Association between Iron Deficiency and Survival in Older Patients with Cancer
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73. Electromagnetic fields regulate iron metabolism: From mechanisms to applications
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74. Ferroptosis, free radicals, and cancer
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75. Re-defining iron deficiency in patients with heart failure
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76. A pH/STEAP Cascade‐Responsive Nanomedicine with Self‐Supplied Peroxide for Precise Chemodynamic Therapy
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77. Prediction of Post-Stroke Cognitive Impairment Based on Iron Metabolism Parameters: Results From A Prospective Study
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78. Ferroptosis and head and neck cancer: Mechanisms and therapeutic perspectives (Review)
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80. Effect of High Static Magnetic Field (2 T–12 T) Exposure on the Mineral Element Content in Mice
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82. Impact of Indole Inclusion in the Design of Multi-Tactical Metal-Binding Tetra-Aza Macrocycles that Target the Molecular Features of Neurodegeneration
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83. A Simple Replica Method as the Way to Obtain a Morphologically and Mechanically Bone-like Iron-Based Biodegradable Material
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84. Transferrin Receptor and Targeting Strategies
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85. Developing Ligands to Target Transition Metals in Cancer
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87. Conformational Transduction Amplification in a Biomimetic Polyelectrolyte for Ultrasensitive Imaging of Iron Metabolism
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95. Plasma Non-transferrin-Bound Iron Could Enter into Mice Duodenum and Negatively Affect Duodenal Defense Response to Virus and Immune Responses
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96. Tumoral Overexpression of Hepcidin is Associated with Poor Prognosis of Patients with Clear Cell Renal Cell Carcinoma
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97. Radical sensing keeps noxious iron at bay
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99. Structure of human ferroportin bound to hepcidin reveals mechanisms of iron homeostasis
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100. Expressional prerequisites for targeted drug delivery to the pathological brain
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