The DOI matches its Crossref record; 216 of the 216 references it cites were found in a registry or an index.
Senescent cells: an emerging target for diseases of ageing
Open accessAbstract
Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“In cancer, the SASP can frequently promote therapy resistance and recurrence [34].”
From The role of cellular senescence and SASP in tumour microenvironment (2023) · cites this paper as [34]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“By contrast, almost all the targeted senolytics are repurposed anticancer agents except the FOXO4-p53 interfering peptide2–4.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“While senescence has beneficial functions (such as tumor suppression), senescent cells accumulate in most tissues with age, and they are important components of the overall aging process62.”
From The role of retrotransposable elements in ageing and age-associated diseases (2021) · cites this paper as [62]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Several senolytic drugs, such as ABT‐737, BET inhibitors and dasatinib plus quercetin, can selectively induce cell death in senescent cells and effectively improve some symptoms of age‐related disease, including cancer, by attenuating SASP factor production.81”
From Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer (2020) · cites this paper as [81]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The literature is becoming inundated with evidence that senescent cells accumulate in a variety of age-associated diseases13.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [13]
In the citing paper
“In particular, this failsafe cellular senescence reportedly occurs in response to (1) potentially carcinogenic events including oncogene activation or oncosuppressor gene inactivation; and (2) several sublethal cellular insults, including telomere shortening, DNA damage, mitochondrial dysfunction, defective/stalled DNA replication and epigenetic, lysosomal, mechanical, metabolic, mitotic, ox”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [958]
In the citing paper
“Genetic and pharmacological strategies have demonstrated the benefits of eliminating senescent cells in the context of aging and disease 10,12,51.”
From Cardiac glycosides are broad-spectrum senolytics (2019) · cites this paper as [51]
In the citing paper
“Organismal aging and age-related diseases promote an accumulation of senescent cells in a variety of tissues in both humans and mice (8).”
From Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives (2018) · cites this paper as [8]
In the citing paper
“Senescent cells are more than simple bystanders, as multiple molecules involved in the SASP act as promoters of atherosclerosis and are biomarkers of CVD risk.23”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [23]
In the citing paper
“Small molecules that can selectively kill SCs, termed senolytics, have the potential to prevent and treat a growing number of age-related diseases and extend healthspan2–4.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
In the citing paper
“SCs accumulate with age and as a result of the exposure to a variety of stressors including radiation.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
In the citing paper
“They play a causal role in many age-related diseases (such as neurodegenerative and cardiovascular diseases, osteoarthritis, and cancer) via expression of the senescence-associated secretory phenotype (SASP) to secret various inflammatory mediators and proteases1–7.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
In the citing paper
“Our studies also confirm some of the previous observations that SCs from different cellular origins and tissues show variable sensitivities to different senolytic agents2–5.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
In the citing paper
“This observation is in agreement with the suggestion that different SCs can use different anti-apoptotic pathways (SCAPs) to resist apoptosis2–5.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
In the citing paper
“Cell senescence occurs throughout the lifespan but plays a larger role with aging and is postulated to contribute to many diseases of aging including vascular disease, arthritis, and neurodegeneration. 38”
From Alzheimer’s disease drug development pipeline: 2021 (2021) · cites this paper as [38]
In the citing paper
“Excessive accumulation of senescent cells in numerous tissues leads to multiple chronic diseases, tissue dysfunction, age-related diseases and organ ageing.”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [14]
In the citing paper
“However, excessive accumulation of senescent cells causally shortens the healthy lifespan [11] and drives organ ageing [12], age-related organ deterioration/disorders [13,14], tissue dysfunction and chronic diseases, including cardiovascular diseases (CVDs) [15,16], cancer [2], neurodegenerative diseases [17,18] and osteoarthritis [19].”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [14]
In the citing paper
“However, the senolytic drugs identified to date were not discovered by a truly unbiased high-throughput screening (HTS) method, and thus appear to have limitations in clinical applications15,17–19.”
From A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells (2020) · cites this paper as [15]
In the citing paper
“the combination of dasatinib and quercetin (D + Q), another previously reported senolytic drug20, apparently exhibited remarkable cell-type specificity15”
From A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells (2020) · cites this paper as [15]
In the citing paper
“in a phase II study of ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL2 and BCL-xL)19 for the treatment of advanced and recurrent small-cell lung carcinoma patients, transient thrombocytopenia and neutropenia were reported as side-effects15.”
From A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells (2020) · cites this paper as [15]
In the citing paper
“Cellular senescence impairs the ability of tissue regeneration and drives chronic low-grade inflammation, which exacerbates the aging process.5,6”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [6]
In the citing paper
“Cellular senescence impairs the ability of tissue regeneration and drives chronic low-grade inflammation, which exacerbates the aging process.5,6”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [6]
In the citing paper
“These studies demonstrated that senescence is one of the major drivers of aging and that clearing senescent cells is a promising approach to treat age-related diseases and improve physical function.6,10”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [6]
In the citing paper
“However, senolytic drugs have significant limitations in killing senescent cells in terms of specificity and broad-spectrum activity because of the dynamic and highly heterogeneous nature of the senescence program, which leads to the varying sensitivity of different types of senescent cells to current senolytic drugs.6,16,17”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [6]
In the citing paper
“SASP contributes to local and systemic low-grade inflammation during aging, to age-related degenerative phenotypes, and to impairment of physical function.5,6,43”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [6]
In the citing paper
“Senescent cells produce a distinct inflammatory secretome and have been found to accumulate with age and in many diseases; potentially contributing to pathology [17–21].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [17]
In the citing paper
“Senescent cells produce a distinct inflammatory secretome and have been found to accumulate with age and in many diseases; potentially contributing to pathology [17–21].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876
Lawrence, R. C., Felson, D. T., Helmick, C. G., Arnold, L. M., Choi, H. K., Deyo, R. A., Gabriel, S. E., Hirsch, R., Hochberg, M. C., Hunder, G. G., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23176 · Cited by 5,599
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Self-citationA new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650
Chronic Health Conditions in Adult Survivors of Childhood Cancer
Oeffinger, K. C., Mertens, A. C., Sklar, C. A., Kawashima, T. I., Hudson, M. M., Meadows, A. T., Friedman, D. L., Marina, N. M., Hobbie, W. L., Kadan‐Lottick, N. S., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmsa060185 · Cited by 3,597
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954
Research works printed but not linked: 1
- Weismann, A. Collected Essays upon Heredity and Kindred Biological Problems (ed. Poulton, E. B.) (Clarendon, 1881).
Cited by
Sorted by citations
Items 701–800 of 1,000
Smirnov, E. Y., Silonov, S. A., Shmidt, E. A., Nozdracheva, A., Pleskach, N., Kuranova, M. L., Gavrilova, A. A., Romanovich, A. E., Константинович, Т. К., Константинович, Т. К., et al. (2024) · Cells · doi:10.3390/cells13242075 · Cited by 12
Injectable Senolytic Hydrogel Depot for the Clearance of Senescent Cells
Paganella, L. G., Bovone, G., Cuni, F., Labouesse, C., Cui, Y., Giampietro, C., & Tibbitt, M. W. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.4c00851 · Cited by 12
Photoactivatable Exosenolytics Activate Natural Killer Cells for Delaying Osteoarthritis
Zhang, L., Xiang, K., Li, J., Hao, M., Zhu, Z., Wang, S., & Sun, H. (2025) · ACS Nano · doi:10.1021/acsnano.5c03344 · Cited by 14
Mbhenyane, X. G., Makuse, S. H., Tambe, A. B., & Zuma, M. K. (2025) · Frontiers in Sustainable Food Systems · doi:10.3389/fsufs.2025.1601914 · Cited by 12
Dietary Technologies to Optimize Healing from Injury-Induced Inflammation
Sears, B., Perry, M., & Saha, A. K. (2020) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/1871523019666200512114210 · Cited by 13
TGFβ1 Induces Senescence and Attenuated VEGF Production in Retinal Pericytes
Avramović, D., Archaimbault, S. A., Kemble, A. M., Gruener, S., Lazendic, M., & Westenskow, P. D. (2022) · Biomedicines · doi:10.3390/biomedicines10061404 · Cited by 12
He, Y., Lipa, K. E., Alexander, P. G., Clark, K. L., & Lin, H. (2022) · Biology · doi:10.3390/biology11070996 · Cited by 13
Investigation of MicroRNA Biomarkers in Equine Distal Interphalangeal Joint Osteoarthritis
Baker, M. E., Lee, S., Clinton, M., Hackl, M., Castanheira, C., Peffers, M. J., & Taylor, S. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415526 · Cited by 12
Cellular senescence and developmental defects
Klein, A., Rhinn, M., & Keyes, W. M. (2023) · FEBS Journal · doi:10.1111/febs.16731 · Cited by 14
Tumor senescence leads to poor survival and therapeutic resistance in human breast cancer
Zhai, J., Han, J., Li, C., Lv, D., Ma, F., & Xu, B. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1097513 · Cited by 12
Li, S., Wang, F., Xing, X., Yue, X., Sun, S., Lin, H., & Xu, C. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202303476 · Cited by 12
Zarakowska, E., Czerwińska, J., Tupalska, A., Yousefzadeh, M., Gregg, S. Q., Croix, C. M. S., Niedernhofer, L. J., Foksiński, M., Gackowski, D., Szpila, A., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly012 · Cited by 12
Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases
Tachikart, Y., Malaise, O., Mumme, M., Jørgensen, C., & Brondello, J. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.03.017 · Cited by 12
Nadeau, S., Cheng, A., Colmegna, I., & Rodier, F. (2019) · Methods in molecular biology · doi:10.1007/7651_2019_217 · Cited by 13
Mitochondria‐Targeting Plasmonic Spiky Nanorods Increase the Elimination of Aging Cells in Vivo
Lu, M., Qu, A., Li, S., Sun, M., Xu, L., Kuang, H., & Xu, C. (2020) · Angewandte Chemie · doi:10.1002/ange.202002576 · Cited by 12
Cholesterol drives inflammatory senescence
Kuehnemann, C., & Wiley, C. D. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00758-2 · Cited by 12
In vivo dynamics of senescence in rhabdomyolysis-induced acute kidney injury
Harris, A. S., Aratani, S., Johmura, Y., Suzuki, N., Li, D., & Nakanishi, M. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.06.046 · Cited by 11
Gcn5- and Bre1-mediated Set2 degradation promotes chronological aging of Saccharomyces cerevisiae
Li, Y., Mei, Y.-C., Liu, A.-H., Wang, R., Chen, R., & Du, H. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113186 · Cited by 12
Gao, X., Hu, Y., Zhang, Y., Huang, Y., Zhang, G., Zhang, X., Zhou, Y., & Zhang, D. (2025) · Science Advances · doi:10.1126/sciadv.adr2833 · Cited by 11
Anti-aging effect of tea and its phytochemicals
Liang, H., Mei, Q., Ang, S., Li, D., & He, C. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116572 · Cited by 11
Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations
Gong, N., Pan, X., Deng, Y., Che, J., Bao, J., Wang, M., Xu, C., Liu, X., & Shi, Y. (2025) · MedComm · doi:10.1002/mco2.70515 · Cited by 14
Emerging Interventions for Elderly Patients—The Promise of Regenerative Medicine
Miller, R. R., & Roubenoff, R. (2018) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1272 · Cited by 11
Chiral CuxCoyS Nanoparticles under Magnetic Field and NIR Light to Eliminate Senescent Cells
Li, S., Sun, M., Hao, C., Qu, A., Wu, X., Xu, L., Xu, C., & Kuang, H. (2020) · Angewandte Chemie · doi:10.1002/ange.202004575 · Cited by 11
Yamaguchi, Y., Zampino, M., Tanaka, T., Bandinelli, S., Osawa, Y., Ferrucci, L., & Semba, R. D. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa324 · Cited by 11
The emerging role of cellular senescence in complications of COVID-19
Mohiuddin, M., & Kasahara, K. (2021) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2021.100399 · Cited by 11
Chan, J., Eide, I. A., Tannæs, T. M., Waldum-Grevbo, B. E., Jenssen, T. G., & Svensson, M. (2021) · Kidney Medicine · doi:10.1016/j.xkme.2021.07.010 · Cited by 11
Targeted Therapeutics Delivery by Exploiting Biophysical Properties of Senescent Cells
Low, J., Chan, B., & Tay, A. K. P. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202107990 · Cited by 11
Fuellen, G., Walter, U., Henze, L., Böhmert, J., Palmer, D. H., Lee, S., Schmitt, C. A., Rudolf, H., & Kowald, A. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01260-1 · Cited by 11
FAK Executes Anti-Senescence via Regulating EZH2 Signaling in Non-Small Cell Lung Cancer Cells
Chuang, H.-H., Huang, M.-S., Zhen, Y., Chuang, C., Lee, Y., Hsiao, M., & Yang, C. (2022) · Biomedicines · doi:10.3390/biomedicines10081937 · Cited by 11
Muyayalo, K. P., Tao, D., Lin, X., & Zhang, Y. (2022) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2022.103790 · Cited by 11
The Possible Role of Β-Cell Senescence in the Development of Type 2 Diabetes Mellitus
Novoselova, E. G., Lunin, S. M., Khrenov, M. O., Glushkova, O. V., Novoselova, T. V., & Parfenyuk, S. B. (2023) · Cellular Physiology and Biochemistry · doi:10.33594/000000606 · Cited by 11
p19INK4d: More than Just a Cyclin-Dependent Kinase Inhibitor
Han, X., Kuang, Y., Chen, H., Liu, T., Zhang, J., & Liu, J. (2019) · Current Drug Targets · doi:10.2174/1389450120666190809161901 · Cited by 11
Trapp-Fragnet, L., Schermuly, J., Kohn, M., Bertzbach, L. D., Pfaff, F., Denesvre, C., Kaufer, B. B., & Härtle, S. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010006 · Cited by 11
NAD+ metabolism controls inflammation during senescence
Nacarelli, T., & Zhang, R. (2019) · Molecular & Cellular Oncology · doi:10.1080/23723556.2019.1605819 · Cited by 11
Chen, X., Walton, K. L., Brodaty, H., & Chalton, K. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231222 · Cited by 10
Cao, Y., Du, X., Yu, J., Wang, Y., Jin, X. M., Gu, B., & Yin, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117433 · Cited by 10
Chen, Y., Zhao, N., Zhang, Y. L., Chen, X., Chen, Y., Wang, Y., Wu, J., & Zhao, W. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae294 · Cited by 10
CCL11 (Eotaxin) Promotes the Advancement of Aging-Related Cardiovascular Diseases
Zhang, T., Huang, Y., Ji, X., Wu, T., & Xiao, P. (2025) · Reviews in Cardiovascular Medicine · doi:10.31083/rcm26020 · Cited by 10
Virus‐Induced Cellular Senescence Causes Pulmonary Sequelae Post‐Influenza Infection
Lipskaia, L., Delval, L., Sencio, V., Born, E., Heumel, S., Houssaini, A., Valentin, C., Raviola, S., Deruyter, L., Angulo, F. S., et al. (2025) · Aging Cell · doi:10.1111/acel.70140 · Cited by 10
ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation
Luo, Y., Zeng, Y., Liu, Y., Liu, S., Dai, Y., Pan, W., Zhang, L., Zhu, R., Feng, D., Du, K., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03474-1 · Cited by 10
Characterizing primary and secondary senescence in vivo
Sogabe, Y., Shibata, H., Kabata, M., Tanaka, A., Mitsunaga, K., Sunadome, K., Nakajima‐Koyama, M., Hirano, M., Nishida, E., Woltjen, K., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00917-y · Cited by 14
Dicer1 deficient mice exhibit premature aging and metabolic perturbations in adipocytes
de Cauwer, A., Loustau, T., Erne, W., Pichot, A., Molitor, A. M., Stemmelen, T., Carapito, R., Orend, G., Bahram, S., & Georgel, P. (2022) · iScience · doi:10.1016/j.isci.2022.105149 · Cited by 11
Piletska, E. V., Thompson, D. L., Jones, R. M., García‐Cruz, Á., Poblocka, M., Canfarotta, F., Norman, R., Macip, S., Jones, D. J. L., & Piletsky, S. A. (2022) · Nanoscale Advances · doi:10.1039/d2na00424k · Cited by 10
Burnaevskiy, N., Oshima, J., & Mendenhall, A. (2022) · GeroScience · doi:10.1007/s11357-022-00709-x · Cited by 10
Zhang, Q., Qi, J., Luo, Q., Wu, M., Zhang, L., Qin, L., & Nie, X. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5415 · Cited by 10
Melanocortin therapies to resolve fibroblast-mediated diseases
Khodeneva, N., Sugimoto, M. A., Davan-Wetton, C. S. A., & Montero‐Melendez, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1084394 · Cited by 10
Przybylski, P., Lewińska, A., Rzeszutek, I., Błoniarz, D., Moskal, A., Betlej, G., Deręgowska, A., Cybularczyk‐Cecotka, M., Szmatoła, T., Litwinienko, G., et al. (2023) · Cancers · doi:10.3390/cancers15235614 · Cited by 10
Hellani, F., Leleu, I., Saïdi, N., Martin, N., Lecœur, C., Werkmeister, E., Koffi, D., Trottein, F., Etté, H. Y., Das, B. K., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.12.030 · Cited by 10
Conte, E., Mantuano, P., Boccanegra, B., Imbrici, P., Dinoi, G., Lenti, R., Cappellari, O., Cappetta, D., Angelis, A. D., Berrino, L., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1393746 · Cited by 10
FGF receptors mediate cellular senescence in the cystic fibrosis airway epithelium
Easter, M., Hirsch, M. J., Harris, E. S., Howze, P. H., Matthews, E. L., Jones, L., Bollenbecker, S., Vang, S., Tyrrell, D. J., Sanders, Y. Y., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.174888 · Cited by 10
Xu, L.-W., Sun, Y.-D., Fu, Q.-Y., Wu, D., Lin, J., Wang, C., Zhang, L., Liu, C., & Li, Q. (2024) · Aging · doi:10.18632/aging.206117 · Cited by 10
Fang, B., Zheng, C., Ma, Y., Wu, F., Cheng, L., Li, Y., Wang, R., & Ren, F. (2024) · Food, Nutrition and Health. · doi:10.1007/s44403-024-00006-9 · Cited by 11
Zhang, G., Li, Y., Li, N., Shen, L., & Li, Z. (2022) · Aging · doi:10.18632/aging.203944 · Cited by 10
Targeting cellular senescence: A promising approach in respiratory diseases
Sugimoto, M. (2023) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14653 · Cited by 9
Maroun, G., Fissoun, C., Villaverde, M., Brondello, J., & Pers, Y. (2023) · Joint Bone Spine · doi:10.1016/j.jbspin.2023.105640 · Cited by 10
Ruple, B. A., Mattingly, M. L., Godwin, J. S., McIntosh, M. C., Kontos, N. J., Agyin-Birikorang, A., Michel, J. M., Plotkin, D. L., Chen, S., Ziegenfuss, T. N., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202302103rrr · Cited by 9
Delaying Renal Aging: Metformin Holds Promise as a Potential Treatment
Qiao, Z., Zhao, J., Yuan, J., Qin, Y., Zhu, Z., Liu, J., & Sun, S. (2024) · Aging and Disease · doi:10.14336/ad.2024.0168 · Cited by 10
Zhao, P., Chang, J., Chen, Y.-J., Sun, X., Ma, X., Zhou, C., Zhou, L., Wang, Y., & Yang, Y. (2024) · Phenomics · doi:10.1007/s43657-023-00132-y · Cited by 9
Rejuvenation Strategy for Inducing and Enhancing Autoimmune Response to Eliminate Senescent Cells
Wang, X., Zhang, C., Su, J., Ren, S., Wang, X., Zhang, Y., Yuan, Z., He, X., Wu, X., Li, M., et al. (2025) · Aging and disease · doi:10.14336/ad.2024.0579 · Cited by 8
Zheng, H., Wu, J., Feng, J., & Cheng, H. (2024) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s403417 · Cited by 9
Wang, T., Chen, J., Qu, B., Zhou, D., & Hong, Z. (2024) · Cell Proliferation · doi:10.1111/cpr.13790 · Cited by 9
Oh, S. J., Kim, Y. H., Kim, B. R., Seo, H., Kwon, S., Choi, H., Lee, H., Na, J., Choi, C. P., Ko, J. Y., et al. (2025) · Annals of Dermatology · doi:10.5021/ad.24.167 · Cited by 9
Zhang, R., Nie, P., Zhou, Y., He, J., Wang, L., Xu, H., & Fu, F. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111535 · Cited by 9
Yu, F., Yin, B.-F., Liu, M., Zhang, W., Zhao, Z., Wang, L., Li, X., Li, P., Li, Z., Xu, R.-X., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04342-1 · Cited by 9
Teng, M. F., Wu, T.-J., Pritchard, K. A., Day, B. W., Naylor, S., & Teng, R. (2025) · Antioxidants · doi:10.3390/antiox14070844 · Cited by 9
Zhang, M., Sun, X., Lu, M. X., Wang, X., Liu, S., Hu, X., He, J., Luo, B., & Wu, Y. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.07.034 · Cited by 9
Zhang, B., Long, Q., Wu, S., Xu, Q., Song, S., Han, L., Qian, M., Ren, X., Liu, H., Jiang, J. H., et al. (2025) · Aging Cell · doi:10.1111/acel.70194 · Cited by 9
Operationalizing Chronic Inflammation: An Endotype-to-Care Framework for Precision and Equity
Ramos‐Niño, M. E. (2025) · Clinics and Practice · doi:10.3390/clinpract15120233 · Cited by 9
Aging and lung diseases: Unraveling mechanisms and therapeutic targets
Zhou, Y., Chen, G., Li, X., Li, X., Lin, Z., Liu, L., Pu, D., Chen, J., Chen, Y., Lin, Z., et al. (2025) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2025.11.005 · Cited by 10
Senescent cells in systemic aging: SASP heterogeneity, immune escape, and endocrine modulation
Qoura, L. A., Churov, A. V., Maltseva, O. N., Ерусланова, К. А., & Zeng, G. (2026) · Biogerontology · doi:10.1007/s10522-026-10449-6 · Cited by 9
Exploring Microenvironment Strategies to Delay Mesenchymal Stem Cell Senescence
Guo, X.-H., Wang, J., Zou, W., Wei, W., Guan, X., & Liu, J. (2021) · Stem Cells and Development · doi:10.1089/scd.2021.0254 · Cited by 9
Franceschi, C., Capri, M., Garagnani, P., Ostan, R., Santoro, A., Monti, D., & Salvioli, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_45-1 · Cited by 9
Aging is a Side Effect of the Ontogenesis Program of Multicellular Organisms
Salnikov, L. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922120070 · Cited by 9
Habiballa, L., Hruby, A. J., Granic, A., Dodds, R. M., Hillman, S. J., Jurk, D., Passos, J. F., & Sayer, A. A. (2023) · GeroScience · doi:10.1007/s11357-023-00869-4 · Cited by 10
Design and optimization of piperlongumine analogs as potent senolytics
Zhang, X., He, Y., Liu, X., Zhang, X., Shi, P., Wang, Y., Zhou, D., & Zheng, G. (2023) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2023.129593 · Cited by 9
Non‐pituitary growth hormone enables colon cell senescence evasion
Chesnokova, V., Zonis, S., Apaydın, T., Barrett, R. J., & Melmed, S. K. (2024) · Aging Cell · doi:10.1111/acel.14193 · Cited by 9
LARP7 overexpression alleviates aortic senescence and atherosclerosis
Yang, P., Wu, S., Li, Y., Lou, Y., Xiong, J., Wang, Y., Geng, Z., & Zhang, B. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18388 · Cited by 9
Inflammaging: Expansion of Molecular Phenotype and Role in Age-Associated Female Infertility
Иванов, Д. О., Дробинцева, А. О., Rodichkina, V. R., Mironova, E. S., Zubareva, T. S., Krylova, Y. S., Morozkina, S. N., Marasco, M. G. P., Mazzoccoli, G., Nasyrov, R. A., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12091987 · Cited by 9
Lázničková, P., Bendíčková, K., Kepák, T., & Frič, J. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.708788 · Cited by 10
Xiao, R., Hu, S., Du, X., Wang, Y., Fang, K., Zhu, Y., Lou, N., Yuan, C., & Yang, J. (2024) · Aging and Disease · doi:10.14336/ad.202.0565 · Cited by 8
Cell Senescence and the DNA Single-Strand Break Damage Repair Pathway
Sarma, P. A. P., Abbadie, C., de Launoit, Y., & Cleri, F. (2024) · DNA · doi:10.3390/dna4040036 · Cited by 8
Dworak, H., Rozmaric, T., Grillari, J., & Ogrodnik, M. B. (2025) · FEBS Letters · doi:10.1002/1873-3468.70037 · Cited by 8
Wang, H., Zhang, J., Ning, J., Cui, Y., Hou, H., Liu, M. R., Liu, J., Tang, R., & Wang, J. (2025) · The journal of nutrition health & aging · doi:10.1016/j.jnha.2025.100575 · Cited by 8
Pu, N., Li, S., Wu, H., Zhao, N., Wang, K., Dong, W., Wang, J., Sha, L., Zhao, Y., Tao, Y., et al. (2025) · Antioxidants · doi:10.3390/antiox14050561 · Cited by 8
Xu, Y., Xie, Z., Gu, S., Zhao, X., Zhao, D., Wu, Z., Wang, J., Xu, T., Xu, R., Feng, Z., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06798-4 · Cited by 8
Huang, Z., Liu, X., Zhou, X., Chen, K., Diao, H., Wang, M., Wei, J., Li, Z., Yang, Y., Mao, Z., et al. (2025) · Aging Cell · doi:10.1111/acel.70203 · Cited by 8
Diabetes reshapes pancreatic cancer-associated endothelial niche by accelerating senescence
Ling, Y., Duan, J., Jiang, Z., Yang, Z., Liu, J.-J., Song, P., Fang, Z.-Q., Yue, Z., He, F., Ke-feng, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63801-8 · Cited by 8
Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction
Song, Y., Xing, H., Luo, Y., Li, B., Li, Y., & Dong, Z. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00545-5 · Cited by 8
Gu, X., Lin, M. M.-W., Xia, Y., Cheng, X., Pan, H., Cai, M., Jiang, M., & Yao, D. (2026) · Biomedicines · doi:10.3390/biomedicines14030636 · Cited by 9
Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program
Palikyras, S., Varamogianni‐Mamatsi, V., Zhu, Y., Mizi, A., Ramasamy, S., Grini, J. V., Liebermann, I., Stavropoulou, A., Penagos‐Puig, A., Ogurlu-Tank, T. S., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01171-6 · Cited by 10
Nutrition Interventions of Herbal Compounds on Cellular Senescence
Chen, Z., Wu, Y., Lin, Q., Cai, J., Liu, X., & Liang, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1059257 · Cited by 8
Interaction of aging and Immunosenescence: New therapeutic targets of aging
Liao, S., Ning, Q., Chen, Y., Zhao, X., & Tang, S. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109397 · Cited by 8
Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
Homolak, J. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.02.018 · Cited by 8
Recent Advancement in Elimination Strategies and Potential Rejuvenation Targets of Senescence
Kureel, S. K., Blair, B., & Sheetz, M. P. (2023) · Advanced Biology · doi:10.1002/adbi.202300461 · Cited by 8
Dotou, M., L’honoré, A., Moumné, R., & Amri, C. E. (2024) · Journal of Natural Products · doi:10.1021/acs.jnatprod.3c01195 · Cited by 8
Przyklenk, M., Karmacharya, S., Bonasera, D., Pasanen-Zentz, A. L., Kmoch, S., Paulsson, M., Wagener, R., Liccardi, G., & Schiavinato, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-59901-y · Cited by 8
Role of natural products in cardiovascular disease
Dong, Q., Dai, G., Quan, N., & Tong, Q. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05048-3 · Cited by 8
Recovering single-cell expression profiles from spatial transcriptomics with scResolve
Chen, H., Lee, Y. J., Ovando-Ricárdez, J. A., Rosas, L., Rojas, M., Mora, A. L., Bar‐Joseph, Z., & Lugo-Martinez, J. (2024) · Cell Reports Methods · doi:10.1016/j.crmeth.2024.100864 · Cited by 9
Yan, Z., Zhang, L., Ma, T., Yuan, Y., Kang, Y., Liu, S., Chen, B., Li, K., Xiao, M., & Xie, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1543277 · Cited by 8
Metadata
- Authors
- Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M.
- Affiliations
- Mayo Clinic (US)
- Unity Biotechnology (United States) (US)
- Venue
- Nature Reviews Drug Discovery
- Published
- 2017-07-21
- Volume
- 16
- Issue
- 10
- Pages
- 718-735
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC5942225
- OpenAlex
- W2739438570
- Cited by
- 1,284
- References
- 216
- Citations by year
- 2026: 146 · 2025: 157 · 2024: 166 · 2023: 162 · 2022: 149 · 2021: 168 · 2020: 146 · 2019: 108 · 2018: 73 · 2017: 8
- FWCI
- 11.24
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institute on Aging (T32AG049672)
- National Cancer Institute (R01CA168709, R01CA096985)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, senescent cells, aging, age-related diseases, cancer, atherosclerosis, osteoarthritis, senolytics, senescence-associated secretory phenotype, cell cycle arrest, cellular stress, senolytic therapy
- MeSH terms
- Aging, Animals, Humans, Neoplasms, Cellular Senescence, Cell Proliferation, Atherosclerosis, Cell Cycle Checkpoints
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
