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Senescent cells: an emerging target for diseases of ageing
Open accessAbstract
Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.
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In the citing paper
“In cancer, the SASP can frequently promote therapy resistance and recurrence [34].”
From The role of cellular senescence and SASP in tumour microenvironment (2023) · cites this paper as [34]
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Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“By contrast, almost all the targeted senolytics are repurposed anticancer agents except the FOXO4-p53 interfering peptide2–4.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“While senescence has beneficial functions (such as tumor suppression), senescent cells accumulate in most tissues with age, and they are important components of the overall aging process62.”
From The role of retrotransposable elements in ageing and age-associated diseases (2021) · cites this paper as [62]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Several senolytic drugs, such as ABT‐737, BET inhibitors and dasatinib plus quercetin, can selectively induce cell death in senescent cells and effectively improve some symptoms of age‐related disease, including cancer, by attenuating SASP factor production.81”
From Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer (2020) · cites this paper as [81]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“SASP contributes to local and systemic low-grade inflammation during aging, to age-related degenerative phenotypes, and to impairment of physical function.5,6,43”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [6]
Experimental — accuracy not yet measured
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In the citing paper
“The literature is becoming inundated with evidence that senescent cells accumulate in a variety of age-associated diseases13.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [13]
The cited source says what the claim attributes to it.
In the citing paper
“SCs accumulate with age and as a result of the exposure to a variety of stressors including radiation.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
The cited source says what the claim attributes to it.
In the citing paper
“Cell senescence occurs throughout the lifespan but plays a larger role with aging and is postulated to contribute to many diseases of aging including vascular disease, arthritis, and neurodegeneration. 38”
From Alzheimer’s disease drug development pipeline: 2021 (2021) · cites this paper as [38]
The cited source says what the claim attributes to it.
In the citing paper
“These studies demonstrated that senescence is one of the major drivers of aging and that clearing senescent cells is a promising approach to treat age-related diseases and improve physical function.6,10”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [6]
In the citing paper
“In particular, this failsafe cellular senescence reportedly occurs in response to (1) potentially carcinogenic events including oncogene activation or oncosuppressor gene inactivation; and (2) several sublethal cellular insults, including telomere shortening, DNA damage, mitochondrial dysfunction, defective/stalled DNA replication and epigenetic, lysosomal, mechanical, metabolic, mitotic, ox”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [958]
In the citing paper
“Genetic and pharmacological strategies have demonstrated the benefits of eliminating senescent cells in the context of aging and disease 10,12,51.”
From Cardiac glycosides are broad-spectrum senolytics (2019) · cites this paper as [51]
In the citing paper
“Organismal aging and age-related diseases promote an accumulation of senescent cells in a variety of tissues in both humans and mice (8).”
From Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives (2018) · cites this paper as [8]
In the citing paper
“Senescent cells are more than simple bystanders, as multiple molecules involved in the SASP act as promoters of atherosclerosis and are biomarkers of CVD risk.23”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [23]
In the citing paper
“Small molecules that can selectively kill SCs, termed senolytics, have the potential to prevent and treat a growing number of age-related diseases and extend healthspan2–4.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
In the citing paper
“They play a causal role in many age-related diseases (such as neurodegenerative and cardiovascular diseases, osteoarthritis, and cancer) via expression of the senescence-associated secretory phenotype (SASP) to secret various inflammatory mediators and proteases1–7.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
In the citing paper
“Our studies also confirm some of the previous observations that SCs from different cellular origins and tissues show variable sensitivities to different senolytic agents2–5.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
In the citing paper
“This observation is in agreement with the suggestion that different SCs can use different anti-apoptotic pathways (SCAPs) to resist apoptosis2–5.”
From Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity (2020) · cites this paper as [2]
In the citing paper
“Excessive accumulation of senescent cells in numerous tissues leads to multiple chronic diseases, tissue dysfunction, age-related diseases and organ ageing.”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [14]
In the citing paper
“However, excessive accumulation of senescent cells causally shortens the healthy lifespan [11] and drives organ ageing [12], age-related organ deterioration/disorders [13,14], tissue dysfunction and chronic diseases, including cardiovascular diseases (CVDs) [15,16], cancer [2], neurodegenerative diseases [17,18] and osteoarthritis [19].”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [14]
In the citing paper
“However, the senolytic drugs identified to date were not discovered by a truly unbiased high-throughput screening (HTS) method, and thus appear to have limitations in clinical applications15,17–19.”
From A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells (2020) · cites this paper as [15]
In the citing paper
“the combination of dasatinib and quercetin (D + Q), another previously reported senolytic drug20, apparently exhibited remarkable cell-type specificity15”
From A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells (2020) · cites this paper as [15]
In the citing paper
“in a phase II study of ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL2 and BCL-xL)19 for the treatment of advanced and recurrent small-cell lung carcinoma patients, transient thrombocytopenia and neutropenia were reported as side-effects15.”
From A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells (2020) · cites this paper as [15]
In the citing paper
“Cellular senescence impairs the ability of tissue regeneration and drives chronic low-grade inflammation, which exacerbates the aging process.5,6”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [6]
In the citing paper
“Cellular senescence impairs the ability of tissue regeneration and drives chronic low-grade inflammation, which exacerbates the aging process.5,6”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [6]
In the citing paper
“However, senolytic drugs have significant limitations in killing senescent cells in terms of specificity and broad-spectrum activity because of the dynamic and highly heterogeneous nature of the senescence program, which leads to the varying sensitivity of different types of senescent cells to current senolytic drugs.6,16,17”
From Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice (2020) · cites this paper as [6]
In the citing paper
“Senescent cells produce a distinct inflammatory secretome and have been found to accumulate with age and in many diseases; potentially contributing to pathology [17–21].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [17]
In the citing paper
“Senescent cells produce a distinct inflammatory secretome and have been found to accumulate with age and in many diseases; potentially contributing to pathology [17–21].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [17]
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Citations
Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876
Lawrence, R. C., Felson, D. T., Helmick, C. G., Arnold, L. M., Choi, H. K., Deyo, R. A., Gabriel, S. E., Hirsch, R., Hochberg, M. C., Hunder, G. G., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23176 · Cited by 5,599
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670
Self-citationA new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650
Chronic Health Conditions in Adult Survivors of Childhood Cancer
Oeffinger, K. C., Mertens, A. C., Sklar, C. A., Kawashima, T. I., Hudson, M. M., Meadows, A. T., Friedman, D. L., Marina, N. M., Hobbie, W. L., Kadan‐Lottick, N. S., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmsa060185 · Cited by 3,597
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954
Research works printed but not linked: 1
- Weismann, A. Collected Essays upon Heredity and Kindred Biological Problems (ed. Poulton, E. B.) (Clarendon, 1881).
Cited by
Sorted by citations
Items 201–300 of 1,000
The redox-senescence axis and its therapeutic targeting
Ngoi, N. Y. L., Liew, A. Q. X., Chong, S. J. F., Davids, M. S., Clement, M., & Pervaiz, S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102032 · Cited by 94
Ketogenic diet induces p53-dependent cellular senescence in multiple organs
Wei, S., Schell, J. R., Chocrón, E. S., Varmazyad, M., Xu, G., Chen, W. H., Martinez, G. M., Dong, F. F., Sreenivas, P., Trevino, R., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado1463 · Cited by 90
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Cheng, N., Kim, K.-H., & Lau, L. F. (2022) · JCI Insight · doi:10.1172/jci.insight.158207 · Cited by 87
“As the clearance of senescent cells by senolytic drugs is being contemplated for treating a variety of pathologies (79–81), the potential effects of eliminating senescent cells in the context of tissue regeneration and repair warrant careful consideration.”
Waller, D. D., Park, J., & Tsantrizos, Y. S. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1568964 · Cited by 86
Autophagy at the intersection of aging, senescence, and cancer
Cassidy, L. D., & Narita, M. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13269 · Cited by 93
Wang, Y., Che, L., Chen, X., He, Z., Song, D., Yuan, Y., & Liu, C. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.01.009 · Cited by 86
The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression
Dasgupta, N., Arnold, R., Equey, A., Gandhi, A., & Adams, P. D. (2024) · npj Aging · doi:10.1038/s41514-024-00172-2 · Cited by 93
Type I interferons and related pathways in cell senescence
Frisch, S. M., & MacFawn, I. (2020) · Aging Cell · doi:10.1111/acel.13234 · Cited by 89
Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2018) · Biogerontology · doi:10.1007/s10522-018-9762-8 · Cited by 84
Paredes, S., Angulo‐Ibáñez, M., Tasselli, L., Carlson, S. M., Zheng, W., Li, T., & Chua, K. F. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ac118.003325 · Cited by 91
Wang, S., Wang, X., Cheng, Y., Ouyang, W., Sang, X., Liu, J., Su, Y., Liu, Y., Li, C., Yang, L., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3632169 · Cited by 83
Epigenetic Regulation of Inflammatory Signaling and Inflammation-Induced Cancer
Tan, S. Y. X., Zhang, J., & Tee, W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.931493 · Cited by 86
Preininger, M. K., & Kaufer, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116217 · Cited by 88
Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
Amaya-Montoya, M., Pérez-Londoño, A., Guatibonza-García, V., Vargas-Villanueva, A., & Mendivil, C. O. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01287-0 · Cited by 82
Recent advances in the field of caloric restriction mimetics and anti-aging molecules
Martel, J., Chang, S.-H., Wu, C.-Y., Peng, H., Hwang, T., Ko, Y., Young, J. D., & Ojcius, D. M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101240 · Cited by 83
Fontana, L., Mitchell, S. E., Wang, B., Tosti, V., van Vliet, T., Veronese, N., Bertozzi, B., Early, D. S., Maissan, P., Speakman, J. R., et al. (2018) · Aging Cell · doi:10.1111/acel.12746 · Cited by 81
A Blueprint for Characterizing Senescence
Roy, A. L., Sierra, F., Howcroft, K., Singer, D. S., Sharpless, N., Hodes, R. J., Wilder, E. L., & Anderson, J. M. (2020) · Cell · doi:10.1016/j.cell.2020.10.032 · Cited by 81
Ding, F., Lu, L., Wu, C., Pan, X., Liu, B., Zhang, Y., Wang, Y., Wu, W., Yan, B., Zhang, Y., et al. (2022) · Theranostics · doi:10.7150/thno.77630 · Cited by 83
Discovering small-molecule senolytics with deep neural networks
Wong, F., Omori, S., Donghia, N. M., Zheng, E. J., & Collins, J. J. (2023) · Nature Aging · doi:10.1038/s43587-023-00415-z · Cited by 82
Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects
Picos, A., Seoane, N., Campos‐Toimil, M., & Viña, D. (2025) · Biogerontology · doi:10.1007/s10522-025-10256-5 · Cited by 84
Rodenak‐Kladniew, B., Castro, A., Stärkel, P., Galle, M., & Crespo, R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117271 · Cited by 82
Telomere transcription in ageing
Aguado, J., di Fagagna, F. D., & Wolvetang, E. J. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101115 · Cited by 81
The emerging role of cell senescence in atherosclerosis
Wu, C.-M., Zheng, L., Wang, Q., & Hu, Y. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2020-0601 · Cited by 80
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
Culley, M. K., Zhao, J., Tai, Y., Tang, Y., Perk, D., Negi, V., Yu, Q., Woodcock, C.-. C., Handen, A. L., Speyer, G., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci136459 · Cited by 81
Cellular senescence in asthma: from pathogenesis to therapeutic challenges
Wan, R., Srikaram, P., Guntupalli, V., Hu, C., Chen, Q., & Gao, P. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104717 · Cited by 86
Dormant cancer cells: programmed quiescence, senescence, or both?
Truskowski, K., Amend, S. R., & Pienta, K. J. (2023) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10073-z · Cited by 90
Xiang, W., Zhang, T., Li, B., Li, S., Zhang, B., Fang, S., Chen, L., Gong, Y., Huang, B., Feng, D., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00907-0 · Cited by 82
Hallmarks and mechanisms of cellular senescence in aging and disease
Ajoolabady, A., Praticò, D., Bahijri, S., Eldakhakhny, B. M., Tuomilehto, J. O., Wu, F., & Ren, J. T. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02655-x · Cited by 87
Mitochondrial quality control in AMD: does mitophagy play a pivotal role?
Hyttinen, J. M. T., Viiri, J., Kaarniranta, K., & Błasiak, J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2843-7 · Cited by 82
The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes
Griveau, A., Wiel, C., Ziegler, D. V., Bergö, M. O., & Bernard, D. (2020) · Aging Cell · doi:10.1111/acel.13122 · Cited by 79
Cellular Senescence in Lung Fibrosis
Hernández‐González, F., Faner, R., Rojas, M. M., Agustí, A. G. N., Serrano, M., & Sellarés, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137012 · Cited by 79
Inflammation and gut dysbiosis as drivers of CKD–MBD
Evenepoel, P., Stenvinkel, P., Shanahan, C. M., & Pacifici, R. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00736-7 · Cited by 82
Invariant natural killer T cells coordinate removal of senescent cells
Arora, S., Thompson, P. J., Wang, Y., Bhattacharyya, A., Apostolopoulou, H., Hatano, R., Naikawadi, R. P., Shah, A., Wolters, P. J., Koliwad, S., et al. (2021) · Med · doi:10.1016/j.medj.2021.04.014 · Cited by 77
Colloca, G. A., Capua, B. D., Bellieni, A., Fusco, D., Ciciarello, F., Tagliaferri, L., Valentini, V., & Balducci, L. (2020) · Current Oncology Reports · doi:10.1007/s11912-020-00977-w · Cited by 83
Evaluating causality of cellular senescence in non-alcoholic fatty liver disease
Meijnikman, A. S., Herrema, H., Scheithauer, T. P. M., Kroon, J., Nieuwdorp, M., & Groen, A. K. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100301 · Cited by 83
Tighanimine, K., de Freitas, J. A. N. L. F., Nemazanyy, I., Bankolé, A., Benarroch, D., Brodesser, S., Doré, G. R. G., Robinson, L. J., Bénit, P., Ladraa, S., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00972-y · Cited by 82
Wlaschek, M., Singh, K., Sindrilaru, A., Crisan, D., & Scharffetter-Kochanek, K. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.036 · Cited by 76
Salminen, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101280 · Cited by 76
Xu, F., Wang, L., Zhou, R., Zhou, R., Chen, L., Peng, H., Huang, Y., Guo, Q., Luo, X., & Zhou, H. (2023) · Nature Communications · doi:10.1038/s41467-023-38842-6 · Cited by 82
RetractedYuan, F., Gao, Z., Liu, W., Li, H., Zhang, Y., Feng, Y., Song, X., Wang, W., Zhang, J., Huang, C., et al. (2019) · Molecules · doi:10.3390/molecules24193517 · Cited by 76
Targeting senescent cells to attenuate cardiovascular disease progression
Song, P., Zhao, Q., & Zou, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101072 · Cited by 81
Montero-Melendez, T., Nagano, A., Chelala, C., Filer, A., Buckley, C. D., & Perretti, M. (2020) · Nature Communications · doi:10.1038/s41467-020-14421-x · Cited by 75
Hu, Q., Peng, J., Jiang, L., Li, W., Su, Q., Zhang, J., Li, H., Song, M., Cheng, B., Xia, J., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03126-0 · Cited by 83
Coordinate regulation of the senescent state by selective autophagy
Lee, Y., Kim, J., Kim, M.-S., Yoojin, K., Shin, S., Yi, H., Kim, H., Chang, M. J., Chang, C. B., Kang, S., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.008 · Cited by 79
Alle, Q., Le Borgne, E., Bensadoun, P., Lemey, C., Béchir, N., Gabanou, M., Estermann, F., Bertrand‐Gaday, C., Pessemesse, L., Toupet, K., et al. (2022) · Aging Cell · doi:10.1111/acel.13714 · Cited by 66
Yun, J., Hansen, S., Morris, O., Madden, D. T., Libeu, C. P., Kumar, A. J., Wehrfritz, C., Nile, A. H., Zhang, Y., Zhou, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-35487-9 · Cited by 81
Cellular Plasticity: A Route to Senescence Exit and Tumorigenesis
Blander, H. D., Morel, A., Senaratne, A. P., Ouzounova, M., & Puisieux, A. (2021) · Cancers · doi:10.3390/cancers13184561 · Cited by 82
Lyons, C. E., Razzoli, M., & Bartolomucci, A. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105359 · Cited by 76
Therapeutic targeting of senescent cells in the CNS
Riessland, M., Ximerakis, M., Jarjour, A. A., Zhang, B., & Orr, M. E. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01033-z · Cited by 77
Kim, H., Chang, J., Iyer, S., Han, L., Campisi, J., Manolagas, S. C., Zhou, D., & Almeida, M. (2019) · Aging Cell · doi:10.1111/acel.12923 · Cited by 74
Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics
Fu, Q., Duan, R., Sun, Y., & Li, Q. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102352 · Cited by 75
Cottage, C. T., Peterson, N., Kearley, J., Berlin, A., Xiong, X., Huntley, A., Zhao, W., Brown, C., Migneault, A., Zerrouki, K., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0532-1 · Cited by 71
Atherosclerosis: Insights into Vascular Pathobiology and Outlook to Novel Treatments
Wolf, M., & Hunziker, P. (2020) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-020-09961-y · Cited by 74
Endothelial Senescence: A New Age in Pulmonary Hypertension
Culley, M. K., & Chan, S. Y. (2022) · Circulation Research · doi:10.1161/circresaha.121.319815 · Cited by 71
Deng, Y., Chen, Q., Yang, X., Sun, Y., Zhang, B., Wei, W., Deng, S., Meng, J., Hu, Y., Wang, Y., et al. (2024) · Theranostics · doi:10.7150/thno.91119 · Cited by 71
Hitomi, K., Okada, R., Loo, T. M., Miyata, K., Nakamura, A., & Takahashi, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103720 · Cited by 72
Therapeutic Potential of Senolytics in Cardiovascular Disease
Dookun, E., Passos, J. F., Arthur, H. M., & Richardson, G. D. (2022) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07075-w · Cited by 69
Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease
Lynch, S. M., Guo, G., Gibson, D. S., Bjourson, A. J., & Singh, T. (2021) · Cells · doi:10.3390/cells10123367 · Cited by 70
Suda, M., Shimizu, I., Katsuumi, G., Hsiao, C. L., Yoshida, Y., Matsumoto, N., Yoshida, Y., Katayama, A., Wada, J., Seki, M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10522-3 · Cited by 70
Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure
Zhang, L., Smyth, D. R., Al-Khalaf, M. H., Blet, A., Du, Q., Bernick, J., Gong, M., Xu, C., Oh, Y., Roba-Oshin, M., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00181-y · Cited by 74
Cellular senescence: a view throughout organismal life
von Kobbe, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2879-8 · Cited by 70
Untangling senescent and damage‐associated microglia in the aging and diseased brain
Ng, P. Y., McNeely, T. L., & Baker, D. J. (2023) · The FEBS Journal · doi:10.1111/febs.16315 · Cited by 68
Self-citationAdvancements in therapeutic drugs targeting of senescence
Zhu, M., Meng, P., Ling, X., & Zhou, L. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320964125 · Cited by 68
Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells
Nehlin, J. O., Jafari, A., Tencerová, M., & Kassem, M. S. (2019) · Bone · doi:10.1016/j.bone.2019.03.041 · Cited by 68
Multifaceted role of extracellular vesicles in atherosclerosis
Konkoth, A. A., Saraswat, R., Dubrou, C., Sabatier, F., Leroyer, A. S., Lacroix, R., Duchez, A., & Dignat‐George, F. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.11.006 · Cited by 70
Nanomedicine: Photo-activated nanostructured titanium dioxide, as a promising anticancer agent
Lаgopati, N., Evangelou, K., Falaras, P., Tsilibary, E.-P. C., Vasileiou, P. V. S., Havaki, S., Angelopoulou, A., Pavlatou, E. A., & Gorgoulis, V. G. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107795 · Cited by 69
Single-cell RNA sequencing in orthopedic research
Wang, T., Wang, L., Zhang, L., Long, Y., Zhang, Y., & Hou, Z. (2023) · Bone Research · doi:10.1038/s41413-023-00245-0 · Cited by 69
Vascular Aging: Assessment and Intervention
Li, A., Yan, J., Ya, Z., Yu, Z., Tian, S., Khan, A. H., Zhu, Y., Wu, A., Zhang, C., & Tian, X. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s423373 · Cited by 70
Elsallabi, O., Patruno, A., Pesce, M., Cataldi, A., Carradori, S., & Gallorini, M. (2022) · Molecules · doi:10.3390/molecules27030738 · Cited by 67
Senolytic Agent Navitoclax Inhibits Angiotensin II-Induced Heart Failure in Mice
Jia, K., Dai, Y., Liu, A., Li, X., Wu, L., Lu, L., Bao, Y., & Jin, Q. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000878 · Cited by 71
Targeting aging and age-related diseases with vaccines
Wu, R., Sun, F., Zhang, W., Ren, J., & Liu, G.-H. (2024) · Nature Aging · doi:10.1038/s43587-024-00597-0 · Cited by 66
Chiral CuxCoyS Nanoparticles under Magnetic Field and NIR Light to Eliminate Senescent Cells
Li, S., Sun, M., Hao, C., Qu, A., Wu, X., Xu, L., Xu, C., & Kuang, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202004575 · Cited by 66
Systems approaches to investigate the role of NF-κB signaling in aging
Haga, M., & Okada, M. (2022) · Biochemical Journal · doi:10.1042/bcj20210547 · Cited by 67
Zorina, A. I., Zorin, V. L., Kudlay, D. A., & Kopnin, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126655 · Cited by 71
Khalil, R., Diab‐Assaf, M., & Lemaître, J.-M. (2023) · Cells · doi:10.3390/cells12060915 · Cited by 68
- Retracted
Senescence in tissue samples of humans with age-related diseases: A systematic review
Tuttle, C. S. L., Luesken, S. W. M., Waaijer, M. E. C., & Maier, A. B. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101334 · Cited by 68
Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond
Shin, E., Bak, S. H., Park, T., Kim, J.-W., Yoon, S. R., Jung, H., & Noh, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1192907 · Cited by 71
Epigenetic Basis of Cellular Senescence and Its Implications in Aging
Nacarelli, T., Liu, P., & Zhang, R. (2017) · Genes · doi:10.3390/genes8120343 · Cited by 66
Therapy-induced polyploidization and senescence: Coincidence or interconnection?
Sikora, E., Czarnecka‐Herok, J., Bojko, A., & Sunderland, P. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.015 · Cited by 65
Adipose tissue aging is regulated by an altered immune system
Zhang, Y.-X., Ou, M.-Y., Yang, Z.-H., Sun, Y., Li, Q.-F., & Zhou, S.-B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125395 · Cited by 62
Aging and stress induced β cell senescence and its implication in diabetes development
Li, N., Liu, F., Yang, P. C., Xiong, F., Yu, Q., Li, J., Zhou, Z., Zhang, S., & Wang, C. (2019) · Aging · doi:10.18632/aging.102432 · Cited by 64
Cellular senescence in ionizing radiation (Review)
Chen, Z., Cao, K., Xia, Y., Li, Y., Hou, Y., Wang, L., Li, L., Chang, L., & Li, W. (2019) · Oncology Reports · doi:10.3892/or.2019.7209 · Cited by 69
An, S., Cho, S., Kang, J., Lee, S., Kim, H.-S., Min, D., Son, E.-D., & Cho, K. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920338117 · Cited by 62
Raffaele, M., Kovacovicova, K., Frohlich, J., Lo Re, O., Giallongo, S., Oben, J. A., Faldyna, M., Leva, L., Giannone, A. G., Cabibi, D., et al. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00731-0 · Cited by 60
The Jekyll and Hyde of Cellular Senescence in Cancer
Demirci, D., Dayanc, B., Mazi, F. A., & Şentürk, Ş. (2021) · Cells · doi:10.3390/cells10020208 · Cited by 62
Senolytic targets and new strategies for clearing senescent cells
Ge, M., Hu, L., Ao, H.-S., Zi, M., Kong, Q., & He, Y. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111468 · Cited by 64
Pancreatic Cancer and Cellular Senescence: Tumor Microenvironment under the Spotlight
Cortesi, M., Zanoni, M., Pirini, F., Tumedei, M. M., Ravaioli, S., Rapposelli, I. G., Frassineti, G. L., & Bravaccini, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010254 · Cited by 62
Mbara, K. C., Devnarain, N., & Owira, P. M. O. (2022) · Pharmaceutical Medicine · doi:10.1007/s40290-022-00444-w · Cited by 47
Shang, D., Sun, D., Shi, C., Xu, J. L., Shen, M., Hu, X., Liu, H., & Tu, Z. (2020) · Aging Cell · doi:10.1111/acel.13145 · Cited by 63
Malaquin, N., Vancayseele, A., Gilbert, S., Antenor-Habazac, L., Olivier, M., Brahem, Z. A. A., Fred Saad, C., Delouya, G., & Rodier, F. (2020) · Cells · doi:10.3390/cells9071593 · Cited by 60
Macro, Micro, and Molecular. Changes of the Osteochondral Interface in Osteoarthritis Development
Fan, X., Wu, X., Crawford, R., Xiao, Y., & Prasadam, I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.659654 · Cited by 59
Senescence under appraisal: hopes and challenges revisited
Davan-Wetton, C. S. A., Pessolano, E., Perretti, M., & Montero‐Melendez, T. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03746-x · Cited by 61
Induction and Validation of Cellular Senescence in Primary Human Cells
Hernandez‐Segura, A., Brandenburg, S. M., & Demaria, M. (2018) · Journal of Visualized Experiments · doi:10.3791/57782 · Cited by 64
Giuliani, A., Cirilli, I., Prattichizzo, F., Mensa’, E., Fulgenzi, G., Sabbatinelli, J., Graciotti, L., Olivieri, F., Procopio, A. D., Tiano, L., et al. (2018) · Aging · doi:10.18632/aging.101591 · Cited by 58
New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease
Sun, X., & Harris, E. N. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00062.2020 · Cited by 59
Azazmeh, N., Assouline, B., Winter, E., Ruppo, S., Nevo, Y., Maly, A., Meir, K., Witkiewicz, A. K., Cohen, J., Rizou, S. V., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16475-3 · Cited by 57
Cellular senescence and acute kidney injury
Lin, X., Jin, H., Chai, Y., & Shou, S. (2022) · Pediatric Nephrology · doi:10.1007/s00467-022-05532-2 · Cited by 61
Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis
Zhou, S., Zhu, J., Zhou, P., & Gu, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.999600 · Cited by 58
Airway Smooth Muscle Regulated by Oxidative Stress in COPD
Kume, H., Yamada, R., Sato, Y., & Togawa, R. (2023) · Antioxidants · doi:10.3390/antiox12010142 · Cited by 57
Metadata
- Authors
- Childs, B. G., Gluscevic, M., Baker, D. J., Laberge, R.-M., Marquess, D., Dananberg, J., & van Deursen, J. M.
- Affiliations
- Mayo Clinic (US)
- Unity Biotechnology (United States) (US)
- Venue
- Nature Reviews Drug Discovery
- Published
- 2017-07-21
- Volume
- 16
- Issue
- 10
- Pages
- 718-735
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC5942225
- OpenAlex
- W2739438570
- Cited by
- 1,284
- References
- 216
- Citations by year
- 2026: 146 · 2025: 157 · 2024: 166 · 2023: 162 · 2022: 149 · 2021: 168 · 2020: 146 · 2019: 108 · 2018: 73 · 2017: 8
- FWCI
- 11.24
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institute on Aging (T32AG049672)
- National Cancer Institute (R01CA168709, R01CA096985)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, senescent cells, aging, age-related diseases, cancer, atherosclerosis, osteoarthritis, senolytics, senescence-associated secretory phenotype, cell cycle arrest, cellular stress, senolytic therapy
- MeSH terms
- Aging, Animals, Humans, Neoplasms, Cellular Senescence, Cell Proliferation, Atherosclerosis, Cell Cycle Checkpoints
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