The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
New medicines to improve control and contribute to the eradication of malaria
Abstract
Despite being one of the most prevalent tropical diseases, for many years malaria was not a commercial priority for the pharmaceutical industry. However, in response to the emergence and spread of resistance to the available antimalarial drugs, there has been a renaissance in the discovery and development of new medicines to control the disease in the last few years. The persistent threat of resistance means that new molecules with novel mechanisms of action are continually required. Furthermore, the recent call for the elimination and eradication of malaria has prompted an extension of the stages of the life cycle of malaria parasites that should be targeted by new molecules. Recent advances in genome-based technologies and in in vitro screening of whole parasites have broadened the range of therapeutic targets and are accelerating the development of a new generation of treatments for both malaria control and eradication.
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Cites
Artemisinin Resistance in Plasmodium falciparum Malaria
Dondorp, A. M., Nosten, F., Yi, P., Das, D., Phyo, A. P., Tarning, J., Lwin, K. M., Ariey, F., Hanpithakpong, W., Lee, S. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808859 · Cited by 3,424
Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy
Meshnick, S. R., Taylor, T. E., & Kamchonwongpaisan, S. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.2.301-315.1996 · Cited by 710
Cited by
Spiroindolones, a Potent Compound Class for the Treatment of Malaria
Rottmann, M., McNamara, C., Yeung, B. K. S., Lee, M. C. S., Zou, B., Russell, B., Seitz, P., Plouffe, D. M., Dharia, N. V., Tan, J., et al. (2010) · Science · doi:10.1126/science.1193225 · Cited by 1,206
Chemical genetics of Plasmodium falciparum
Guiguemde, W. A., Shelat, A. A., Bouck, D., Duffy, S., Crowther, G. J., Davis, P. H., Smithson, D. C., Connelly, M., Clark, J., Zhu, F., et al. (2010) · Nature · doi:10.1038/nature09099 · Cited by 566
A transcriptional switch underlies commitment to sexual development in malaria parasites
Kafsack, B. F. C., Rovira-Graells, N., Clark, T. G., Bancells, C., Crowley, V. M., Campino, S. G., Williams, A. E., Drought, L. G., Kwiatkowski, D. P., Baker, D. A., et al. (2014) · Nature · doi:10.1038/nature12920 · Cited by 537
Adjalley, S. H., Johnston, G. L., Li, T., Eastman, R. T., Ekland, E. H., Eappen, A. G., Richman, A., Sim, B. K. L., Lee, M. C. S., Hoffman, S. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112037108 · Cited by 309
Priming the antimalarial pipeline
Fidock, D. A. (2010) · Nature · doi:10.1038/465297a · Cited by 116
Metadata
- Authors
- Wells, T. N. C., Alonso, P. L., & Gutteridge, W. E.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2009-10-16
- Volume
- 8
- Issue
- 11
- Pages
- 879-891
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2168950392
- Cited by
- 298
- References
- 2
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wells, T. N. C., Alonso, P. L., & Gutteridge, W. E. (2009). New medicines to improve control and contribute to the eradication of malaria. Nature Reviews Drug Discovery. https://doi.org/10.1038/nrd2972
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
