Priming the antimalarial pipeline

Artemisinin Resistance in <i>Plasmodium falciparum</i> Malaria

Dondorp, A. M., Nosten, F., Yi, P., Das, D., Phyo, A. P., Tarning, J., Lwin, K. M., Ariey, F., Hanpithakpong, W., Lee, S. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808859 · Cited by 3,424 · see citing works

Thousands of chemical starting points for antimalarial lead identification

Gamo, F., Sanz, L. M., Vidal, J., de Cózar, C., Álvarez, E. F., Lavandera, J.-L., Vanderwall, D. E., Green, D. V. S., Kumar, V. D., Hasan, S., et al. (2010) · Nature · doi:10.1038/nature09107 · Cited by 991 · see citing works

Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia

Tjitra, E., Anstey, N. M., Sugiarto, P., Warikar, N., Kenangalem, E., Karyana, M., Lampah, D. A., & Price, R. N. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050128 · Cited by 609 · see citing works

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

Eastman, R. T., & Fidock, D. A. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2239 · Cited by 569 · see citing works

Chemical genetics of Plasmodium falciparum

Guiguemde, W. A., Shelat, A. A., Bouck, D. C., Duffy, S., Crowther, G. J., Davis, P. H., Smithson, D. C., Connelly, M., Clark, J. A., Zhu, F., et al. (2010) · Nature · doi:10.1038/nature09099 · Cited by 561 · see citing works

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

Plouffe, D., Brinker, A., McNamara, C. W., Henson, K., Kato, N., Kuhen, K., Nagle, A. S., Adrián, F., Matzen, J., Anderson, P., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802982105 · Cited by 442 · see citing works

New medicines to improve control and contribute to the eradication of malaria

Wells, T. N. C., Alonso, P. L., & Gutteridge, W. E. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2972 · Cited by 301 · see citing works

The past, present and future of childhood malaria mortality in Africa

Snow, R. W., Trape, J., & Marsh, K. (2001) · Trends in Parasitology · doi:10.1016/s1471-4922(01)02031-1 · Cited by 266 · see citing works

A new global malaria eradication strategy

Feachem, R., & Sabot, O. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60424-9 · Cited by 183 · see citing works

Nanotechnology approaches for global infectious diseases

Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520 · see citing works

The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites

Delves, M. J., Plouffe, D., Scheurer, C., Meister, S., Wittlin, S., Winzeler, E. A., Sinden, R. E., & Leroy, D. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001169 · Cited by 378 · see citing works

In silico repositioning of approved drugs for rare and neglected diseases

Ekins, S., Williams, A. J., Krasowski, M. D., & Freundlich, J. S. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.02.016 · Cited by 288 · see citing works

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

Paquet, T., Manach, C. L., Cabrera, D. G., Younis, Y., Henrich, P. P., Abraham, T. S., Lee, M., Basak, R., Ghidelli, S., Lafuente-Monasterio, M. J., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aad9735 · Cited by 276 · see citing works

Antimalarial Drugs: Modes Of Action And Mechanisms Of Parasite Resistance

Müller, I. B., & Hyde, J. E. (2010) · Future Microbiology · doi:10.2217/fmb.10.136 · Cited by 144 · see citing works

Antiplasmodial Natural Products

Nogueira, C. R., & Lopes, L. M. X. (2011) · Molecules · doi:10.3390/molecules16032146 · Cited by 133 · see citing works

Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review

Wainwright, C. L., Teixeira, M. M., Adelson, D. L., Braga, F. C., Buenz, E. J., Campana, P. R. V., David, B., Glaser, K. B., Harata‐Lee, Y., Howes, M. R., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106076 · Cited by 113 · see citing works

Chemical genetics

Connor, C. J. O., Laraia, L., & Spring, D. R. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15053g · Cited by 111 · see citing works

Suppression of Host p53 Is Critical for Plasmodium Liver-Stage Infection

Kaushansky, A., Ye, A. S., Austin, L. S., Mikolajczak, S. A., Vaughan, A. M., Camargo, N. M., Metzger, P. G., Douglass, A. N., MacBeath, G., & Kappe, S. H. I. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.010 · Cited by 105 · see citing works

High spin cobalt(II) as a probe for the investigation of metalloproteins.

Bertini, I., & Luchinat, C. (1984) · PubMed · Cited by 93 · see citing works

In vitro anti-malarial efficacy of chalcones: cytotoxicity profile, mechanism of action and their effect on erythrocytes

Sinha, S., Batovska, D. I., Medhi, B., Radotra, B. D., Bhalla, A., Markova, N. V., & Sehgal, R. (2019) · Malaria Journal · doi:10.1186/s12936-019-3060-z · Cited by 89 · see citing works

Transmission-blocking drugs for malaria elimination

Birkholtz, L., Alano, P., & Leroy, D. (2022) · Trends in Parasitology · doi:10.1016/j.pt.2022.01.011 · Cited by 85 · see citing works

Malaria parasite liver stages render host hepatocytes susceptible to mitochondria-initiated apoptosis

Kaushansky, A., Metzger, P. G., Douglass, A. N., Mikolajczak, S. A., Lakshmanan, V., Kain, H. S., & Kappe, S. H. I. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.286 · Cited by 83 · see citing works

BindingDB and ChEMBL: online compound databases for drug discovery

Wassermann, A. M., & Bajorath, J. (2011) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2011.579100 · Cited by 83 · see citing works

Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum

Manach, C. L., Scheurer, C., Sax, S., Sarah, S., Cabrera, D. G., Younis, Y., Paquet, T., Street, L. J., Smith, P., Ding, X. C., et al. (2013) · Malaria Journal · doi:10.1186/1475-2875-12-424 · Cited by 81 · see citing works

N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis

Tate, E. W., Bell, A., Rackham, M. D., & Wright, M. H. (2013) · Parasitology · doi:10.1017/s0031182013000450 · Cited by 77 · see citing works

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics

Summers, R., Nash, M. N., & Martin, R. E. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0906-0 · Cited by 78 · see citing works

Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

Gilson, P. R., Tan, C., Jarman, K. E., Lowes, K. N., Curtis, J., Nguyen, W., Rago, A. E. D., Bullen, H. E., Prinz, B., Duffy, S., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01673 · Cited by 71 · see citing works

Identification of Novel Malarial Cysteine Protease Inhibitors Using Structure-Based Virtual Screening of a Focused Cysteine Protease Inhibitor Library

Shah, F., Mukherjee, P., Gut, J., Legac, J., Rosenthal, P., Tekwani, B., & Avery, M. (2011) · Journal of Chemical Information and Modeling · doi:10.1021/ci200029y · Cited by 67 · see citing works

Enlightening the malaria parasite life cycle: bioluminescent Plasmodium in fundamental and applied research

Siciliano, G., & Alano, P. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00391 · Cited by 66 · see citing works

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3‑ b ]pyridine-5-carbonitriles Are Selective Inhibitors of Plasmodium falciparum Glycogen Synthase Kinase‑3

Fugel, W., Oberholzer, A. E., Gschloessl, B., Dzikowski, R., Pressburger, N., Preu, L., Pearl, L. H., Baratte, B., Ratin, M., Okun, I. M., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm301575n · Cited by 66 · see citing works

Approaches to efficiently estimate solvation and explicit water energetics in ligand binding: the use of WaterMap.

Yang, Y., Lightstone, F. C., & Wong, S. E. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.749853 · Cited by 65 · see citing works

Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone–Chloroquine Hybrids

Andayi, W. A., Egan, T. J., Gut, J., Rosenthal, P. J., & Chibale, K. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml4001084 · Cited by 64 · see citing works

Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production

Pulice, G., Pelaz, S., & Matías-Hernández, L. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00329 · Cited by 53 · see citing works

Structure-Function of Falcipains: Malarial Cysteine Proteases

Pandey, K., & Dixit, R. (2012) · Journal of Tropical Medicine · doi:10.1155/2012/345195 · Cited by 50 · see citing works

In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling

BECKER, J., van der Merwe, M. M., van Brummelen, A. C., Pillay, P., Crampton, B. G., Mmutlane, E. M., Parkinson, C. J., van Heerden, F. R., Crouch, N. R., Smith, P. J., et al. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-295 · Cited by 53 · see citing works

Proteomic analysis of Artemisia annua – towards elucidating the biosynthetic pathways of the antimalarial pro-drug artemisinin

Bryant, L. A., Flatley, B., Patole, C., Brown, G. D., & Cramer, R. (2015) · BMC Plant Biology · doi:10.1186/s12870-015-0565-7 · Cited by 50 · see citing works

Synthesis of hybrid 4-anilinoquinoline triazines as potent antimalarial agents, their in silico modeling and bioevaluation as Plasmodium falciparumtransketolase and β-hematin inhibitors

Sharma, M., Chauhan, K., Chauhan, S. S., Kumar, A., Singh, S. V., Saxena, J. K., Agarwal, P., Srivastava, K., Kumar, S. R., Puri, S., et al. (2011) · MedChemComm · doi:10.1039/c1md00188d · Cited by 48 · see citing works

Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10

Zin, N. M., Baba, M. S., Zainal-Abidin, A. H., Latip, J., Mazlan, N. W., & Edrada‐Ebel, R. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s121283 · Cited by 47 · see citing works

Synthesis and in vitro evaluation of 4-trichloromethylpyrrolo[1,2-a]quinoxalines as new antiplasmodial agents

Primas, N., Suzanne, P., Verhaeghe, P., Hutter, S., Kieffer, C., Laget, M., Cohen, A., Broggi, J., Lancelot, J., Lesnard, A., et al. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.06.014 · Cited by 45 · see citing works

Synthesis of 3-heteroarylthioquinoline derivatives and their in vitro antituberculosis and cytotoxicity studies

Chitra, S., Paul, N., Muthusubramanian, S., Manisankar, P., Yogeeswari, P., & Sriram, D. (2011) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2011.07.046 · Cited by 45 · see citing works

Cinnamic Acid Derivatives in Tuberculosis, Malaria and Cardiovascular Diseases - A Review

De, P., Bedos‐Belval, F., Vanucci‐Bacqué, C., & Baltas, M. (2012) · Current Organic Chemistry · doi:10.2174/138527212799958020 · Cited by 45 · see citing works

Computer-Aided Drug Design of Falcipain Inhibitors: Virtual Screening, Structure–Activity Relationships, Hydration Site Thermodynamics, and Reactivity Analysis

Shah, F., Gut, J., Legac, J., Shivakumar, D., Sherman, W., Rosenthal, P. J., & Avery, M. A. (2012) · Journal of Chemical Information and Modeling · doi:10.1021/ci2005516 · Cited by 44 · see citing works

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance

Shahinas, D., Folefoc, A. T., & Pillai, D. (2013) · Pathogens · doi:10.3390/pathogens2010033 · Cited by 45 · see citing works

In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine

Forkuo, A. D., Ansah, C., Mensah, K. B., Annan, K., Gyan, B. A., Theron, A., Mancama, D. T., & Wright, C. W. (2017) · Malaria Journal · doi:10.1186/s12936-017-2142-z · Cited by 43 · see citing works

Tandem synthesis and in vitro antiplasmodial evaluation of new naphtho[2,1-d]thiazole derivatives

Cohen, A., Verhaeghe, P., Crozet, M. D., Hutter, S., Rathelot, P., Vanelle, P., & Azas, N. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.07.034 · Cited by 43 · see citing works

Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition

Caroli, A., Simeoni, S., Lepore, R., Tramontano, A. L., & Via, A. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.12.009 · Cited by 41 · see citing works

An essential role of the basal body protein SAS ‐6 in P lasmodium male gamete development and malaria transmission

Marques, S. R., Ramakrishnan, C., Carzaniga, R., Blagborough, A. M., Delves, M. J., Talman, A. M., & Sinden, R. E. (2014) · Cellular Microbiology · doi:10.1111/cmi.12355 · Cited by 40 · see citing works

Multistage inhibitors of the malaria parasite: Emerging hope for chemoprotection and malaria eradication

Poonam, P., Gupta, Y. A., Gupta, N., Singh, S., Wu, L., Chhikara, B. S., Rawat, M., & Rathi, B. (2018) · Medicinal Research Reviews · doi:10.1002/med.21486 · Cited by 40 · see citing works

Potential of Lichen Secondary Metabolites against Plasmodium Liver Stage Parasites with FAS-II as the Potential Target

Lauinger, I. L., Vivas, L., Perozzo, R., Stairiker, C. J., Tarun, A. S., Zloh, M., Zhang, X., Xu, H., Tonge, P. J., Franzblau, S. G., et al. (2013) · Journal of Natural Products · doi:10.1021/np400083k · Cited by 39 · see citing works

1,4-Naphthoquinone Cations as Antiplasmodial Agents: Hydroxy-, Acyloxy-, and Alkoxy-Substituted Analogues

Lü, X., Altharawi, A., Gut, J., Rosenthal, P. J., & Long, T. E. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml300242v · Cited by 39 · see citing works

A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway

Fletcher, S., & Avery, V. M. (2014) · Malaria Journal · doi:10.1186/1475-2875-13-343 · Cited by 39 · see citing works

Open Drug Discovery Teams: A Chemistry Mobile App for Collaboration

Ekins, S., Clark, A. M., & Williams, A. J. (2012) · Molecular Informatics · doi:10.1002/minf.201200034 · Cited by 38 · see citing works

Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade

Collet, J. W., Ackermans, K., Lambregts, J., Maes, B. U. W., Orrù, R. V. A., & Ruijter, E. (2017) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b02844 · Cited by 38 · see citing works

Biotechnological approaches for artemisinin production in Artemisia

Kayani, W. K., Kiani, B. H., Dilshad, E., & Mirza, B. (2018) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-018-2432-9 · Cited by 37 · see citing works

Antiparasitic Peptides

Pretzel, J., Mohring, F., Rahlfs, S., & Becker, K. (2013) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2013_191 · Cited by 38 · see citing works

Design, synthesis and biological evaluation of novel benzothiazole and triazole analogs as falcipain inhibitors

Shah, F., Wu, Y., Gut, J., Pedduri, Y., Legac, J., Rosenthal, P., & Avery, M. (2011) · MedChemComm · doi:10.1039/c1md00129a · Cited by 27 · see citing works

Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium

Cohen, A., Suzanne, P., Lancelot, J., Verhaeghe, P., Lesnard, A., Basmaciyan, L., Hutter, S., Laget, M., Dumètre, A., Paloque, L., et al. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.03.011 · Cited by 35 · see citing works

A facile synthesis of carbocycle-fused mono and bis-1,2,3-selenadiazoles and their antimicrobial and antimycobacterial studies

Chitra, S., Paul, N., Muthusubramanian, S., Manisankar, P., Yogeeswari, P., & Sriram, D. (2011) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2011.09.007 · Cited by 34 · see citing works

Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids

Kaur, H., Balzarini, J. M., de Kock, C. A., Smith, P. J., Chibale, K., & Singh, K. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.06.024 · Cited by 34 · see citing works

Identification of a New Chemical Class of Antimalarials

Brunner, R., Aissaoui, H., Boss, C., Bozdech, Z., Brun, R., Corminboeuf, O., Delahaye, S., Fischli, C., Heidmann, B., Kaiser, M., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis418 · Cited by 34 · see citing works

Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

de Azevedo, R. S., Markovic, M., Machado, M., Franke-Fayard, B. M. D., Mendes, A. M., & Prudêncio, M. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02699-16 · Cited by 33 · see citing works

Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of Plasmodium In Vivo and In Vitro

Saénz, F. E., Mutka, T., Udenze, K., ODUOLA, A. M. J., & Kyle, D. E. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01061-12 · Cited by 32 · see citing works

Antimalarial Activity of 4-Amidinoquinoline and 10-Amidinobenzonaphthyridine Derivatives

Korotchenko, V. N., Sathunuru, R., Gerena, L., Caridha, D. P., Li, Q., Kreishman-Deitrick, M., Smith, P. L., & Ai, L. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501809x · Cited by 32 · see citing works

Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors

Murillo-Solano, C., Dong, C., Sánchez, C. G., & Pizarro, J. C. (2017) · Malaria Journal · doi:10.1186/s12936-017-1940-7 · Cited by 32 · see citing works

Expression of a Malarial Hsp70 Improves Defects in Chaperone-Dependent Activities in ssa1 Mutant Yeast

Bell, S. L., Chiang, A., & Brodsky, J. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020047 · Cited by 31 · see citing works

A Flow Cytometry-Based Quantitative Drug Sensitivity Assay for All Plasmodium falciparum Gametocyte Stages

Wang, Z., Liu, M., Liang, X., Siriwat, S., Li, X., Chen, X., Parker, D. M., Miao, J., & Cui, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093825 · Cited by 30 · see citing works

Discovery and Characterization of ACT‐451840: an Antimalarial Drug with a Novel Mechanism of Action

Boss, C., Aissaoui, H., Amaral, N., Bauer, A., Bazire, S., Binkert, C., Brun, R., Bürki, C., Ciana, C., Corminboeuf, O., et al. (2016) · ChemMedChem · doi:10.1002/cmdc.201600298 · Cited by 27 · see citing works

Effective and Sustainable Access to Quinolines and Acridines: A Heterogeneous Imidazolium Salt Mediates C–C and C–N Bond Formation

Gisbert, P., Albert‐Soriano, M., & Pastor, I. M. (2019) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201900880 · Cited by 25 · see citing works

Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase–dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance

Yogavel, M., Nettleship, J. E., Sharma, A., Harlos, K., Jamwal, A., Chaturvedi, R., Sharma, M., Jain, V., Chhibber‐Goel, J., & Sharma, A. K. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004558 · Cited by 25 · see citing works

Novel diaryl ureas with efficacy in a mouse model of malaria

Anderson, J. W., Sarantakis, D., Terpiński, J., Kumar, T. R. S., Tsai, H.-C., Kuo, M. R., Ager, A. L., Jacobs, W. R., Schiehser, G. A., Ekins, S., et al. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.12.022 · Cited by 25 · see citing works

Anti-infectives: Can cellular screening deliver?

Keller, T. H., Shi, P., & Wang, Q.-Y. (2011) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2011.06.007 · Cited by 24 · see citing works

From crystal to compound: structure-based antimalarial drug discovery

Drinkwater, N., & McGowan, S. (2014) · Biochemical Journal · doi:10.1042/bj20140240 · Cited by 24 · see citing works

Discovery of 6′-chloro-N-methyl-5’-(phenylsulfonamido)-[3,3′-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium

Liang, X., Jiang, Z., Huang, Z., Li, F., Chen, C., Hu, C., Wang, W., Hu, Z., Liu, Q., Wang, B., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.112012 · Cited by 23 · see citing works

Analysis of the Molecular Mechanisms Governing the Stage-Specific Expression of a Prototypical Housekeeping Gene during Intraerythrocytic Development of P. falciparum

Wong, E., Hasenkamp, S., & Horrocks, P. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.02.043 · Cited by 23 · see citing works

The Ionic and Hydrophobic Interactions Are Required for the Auto Activation of Cysteine Proteases of Plasmodium falciparum

Sundararaj, S., Singh, D., Saxena, A. K., Vashisht, K., Sijwali, P. S., Dixit, R., & Pandey, K. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047227 · Cited by 22 · see citing works

Meta-analysis of molecular property patterns and filtering of public datasets of antimalarial “hits” and drugs

Ekins, S., & Williams, A. J. (2010) · MedChemComm · doi:10.1039/c0md00129e · Cited by 22 · see citing works

Advances in the Treatment of Explicit Water Molecules in Docking and Binding Free Energy Calculations

Hu, X., Maffucci, I., & Contini, A. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180514110824 · Cited by 22 · see citing works

4-(1 H )-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10 H )-Ones Prevent the Transmission of Plasmodium falciparum to Anopheles freeborni

Saénz, F. E., LaCrue, A. N., Cross, R. M., Maignan, J. R., Udenze, K., Manetsch, R., & Kyle, D. E. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00492-13 · Cited by 21 · see citing works

Synthesis and evaluation of a novel series of indoloisoquinolines as small molecule anti-malarial leads

Horrocks, P., Fallon, S. K., Denman, L., Devine, O., Duffy, L. J., Harper, A., Meredith, E.-L., Hasenkamp, S., Sidaway, A., Monnery, D., et al. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.12.071 · Cited by 21 · see citing works

Marine inspired antiplasmodial thiazinoquinones: synthesis, computational studies and electrochemical assays

Imperatore, C., Persico, M., Aiello, A., Luciano, P., Guiso, M., Sanasi, M.-F., Taramelli, D., Parapini, S., Cebrián‐Torrejón, G., Doménech‐Carbó, A., et al. (2015) · RSC Advances · doi:10.1039/c5ra09302c · Cited by 18 · see citing works

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

Fletcher, S., Lucantoni, L., Sykes, M. L., Jones, A. J., Holleran, J. P., Saliba, K. J., & Avery, V. M. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1860-3 · Cited by 17 · see citing works

Rational Structure-Based Drug Design

Khanna, V., Ranganathan, S., & Petrovsky, N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.20275-6 · Cited by 17 · see citing works

Characterization of Plasmodium falciparum Pantothenate Kinase and Identification of Its Inhibitors From Natural Products

Nurkanto, A., Jeelani, G., Santos, H. J., Rahmawati, Y., Mori, M., Nakamura, Y., Goto, K., Saikawa, Y., Annoura, T., Tozawa, Y., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.639065 · Cited by 15 · see citing works

Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes

Paonessa, G., Siciliano, G., Graziani, R., Lalli, C., Cecchetti, O., Alli, C., Valle, R. L., Petrocchi, A., Sferrazza, A., Bisbocci, M., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03510-w · Cited by 14 · see citing works

Antimalarial activities of benzothiazole analogs: A systematic review

Tran, L., Tu, V. L., Dadam, M. N., Aziz, J. M. A., Duy, T. L. D., Ahmed, H., Kwaah, P. A., Quoc, H. N., Dat, T. V., Mizuta, S., et al. (2023) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12974 · Cited by 13 · see citing works

Centenary celebrations article

Pandey, K. C. (2011) · Journal of Parasitic Diseases · doi:10.1007/s12639-011-0084-x · Cited by 13 · see citing works

Docking, synthesis and antimalarial activity of novel 4-anilinoquinoline derivatives

Vijayaraghavan, S., & Mahajan, S. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.03.005 · Cited by 13 · see citing works

Ribonucleotide Reductase as a Target to Control Apicomplexan Diseases

Munro, J. B., & da Silva, J. C. F. (2012) · Current Issues in Molecular Biology · doi:10.21775/cimb.014.009 · Cited by 12 · see citing works

Hidden reservoir of resistant parasites: the missing link in the elimination of falciparum malaria

Abdul-Ghani, R. A., Mahdy, M. A. K., Beier, J. C., & Basco, L. K. (2017) · Infectious Diseases of Poverty · doi:10.1186/s40249-016-0227-5 · Cited by 12 · see citing works

Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages

Weidner, T., Lucantoni, L., Nasereddin, A., Preu, L., Jones, P. G., Dzikowski, R., Avery, V. M., & Kunick, C. (2017) · Malaria Journal · doi:10.1186/s12936-017-1839-3 · Cited by 11 · see citing works

Design, synthesis, biological evaluation and computational study of novel triazolo [4,3-a]pyrazin analogues

Jethava, D. J., Acharya, P. T., Vasava, M. S., Bhoi, M. N., Bhavsar, Z. A., Rathwa, S. K., Rajani, D. P., & Patel, H. D. (2019) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2019.01.091 · Cited by 11 · see citing works

Characterization and redox regulation ofPlasmodium falciparummethionine adenosyltransferase

Pretzel, J., Gehr, M., Eisenkolb, M., Wang, L., Fritz‐Wolf, K., Rahlfs, S., Becker, K., & Jortzik, E. (2016) · The Journal of Biochemistry · doi:10.1093/jb/mvw045 · Cited by 11 · see citing works

Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library

Nurkanto, A., Imamura, R. M., Rahmawati, Y., Prabandari, E. E., Waluyo, D., Annoura, T., Yamamoto, K. Z., Sekijima, M., Nishimura, Y., Okabe, T., et al. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00420-22 · Cited by 10 · see citing works

Purification of artemisinin from quercetin by anti-solvent crystallization

Malwade, C. R., Qu, H., Rong, B., & Christensen, L. P. (2013) · Frontiers of Chemical Science and Engineering · doi:10.1007/s11705-013-1305-x · Cited by 9 · see citing works

Anti-malarial activity of new N-acetyl-l-leucyl-l-leucyl-l-norleucinal (ALLN) derivatives against Plasmodium falciparum

Choi, H., Cui, M., Li, D.-Y., Song, H., Kim, H. S., & Park, H. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.12.100 · Cited by 8 · see citing works

A structural comparative approach to identifying novel antimalarial inhibitors

Franco, J., Blackie, M., Toth, D. M., Smith, P. J., Capuano, J., Fastnacht, K. V., & Berkes, C. A. (2013) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2013.04.002 · Cited by 7 · see citing works

Assessment of the haematological profile of children with malaria parasitaemia treated with three different artemisinin-based combination therapies

Chukwuocha, U. M., Chimezie, O. M., Chima, N. G., Hope, O., & Simplicius, D. I. N. (2015) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(15)60813-1 · Cited by 7 · see citing works

Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity

Thelingwani, R., Bonn, B., Chibale, K., & Masimirembwa, C. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.954547 · Cited by 5 · see citing works

Spectroscopic, computational DFT, in vitro, and molecular docking investigations of newly isolated 2, 3, 9, and 10-tetrahydroacridin-3-one from the methanolic extract of nilavembu kudineer chooranam

Kamalarajan, P., Ahamed, J. I., Priya, R. M., & Valan, M. F. (2022) · Research on Chemical Intermediates · doi:10.1007/s11164-022-04906-3 · Cited by 5 · see citing works

Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) fromPlasmodium falciparum

Buchko, G. W., Yee, A. A., Semesi, A., Myler, P. J., Arrowsmith, C. H., & Hui, R. (2015) · Acta Crystallographica Section F Structural Biology Communications · doi:10.1107/s2053230x1402799x · Cited by 5 · see citing works

The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity

Siciliano, G., Paolo, V. D., Rotili, D., Migale, R., Pedini, F., Casella, M., Camerini, S., Dalzoppo, D., Henderson, R., Huijs, T. T. G., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15020168 · Cited by 5 · see citing works

ML238: An Antimalarial Small Molecule of a Unique Structural Class

Weïwer, M., Mulrooney, C. A., Massi, D., Heidebrecht, R. W., Wiegand, R. C., Lukens, A. K., Dick, J., Wirth, D. F., Ekland, E. H., Cheng, C., et al. (2011) · Cited by 4 · see citing works

Foundation technologies in synthetic biology: tools for use in understanding plant immunity

Moore, J. W. (2012) · ERA · Cited by 4 · see citing works

Assessing Spectral Analysis of Phytoconstituents and Their In Silico Interactions with Target Proteins in Plant Seed Extracts

Babu, V., Ahamed, J. I., Paul, A., Ali, S., Rather, I., & Sabir, J. S. M. (2023) · Plants · doi:10.3390/plants12193352 · Cited by 3 · see citing works

Cysteine Proteases of Human Malaria Parasites

Pandey, K. C. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9233-7_8 · Cited by 3 · see citing works

Anti-Malarial and some Biochemical Indices of the Ethanol Extract of Zapoteca portoricensis Root on Malaria-Infected Mice

Nwodo, O. F. C., Joshua, P. E., Ugwuoke, M. C., & Uroko, R. I. (2015) · Asian Journal of Biochemistry · doi:10.3923/ajb.2015.281.289 · Cited by 3 · see citing works

Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183

Khairnar, P. V., Aleshire, S. L., Ongolu, R. K., jin, L., Laidlaw, M., Donsbach, K. O., Gupton, B. F., Nelson, R. C., & Shanahan, C. S. (2023) · Organic Process Research & Development · doi:10.1021/acs.oprd.3c00353 · Cited by 2 · see citing works

Potential of Herbal Drug Delivery in Treating Malaria

Das, A., Pathak, K., Pathak, M. P., Saikia, R., Gogoi, U., & Acharya, N. S. (2023) · Springer eBooks · doi:10.1007/978-3-031-15848-3_15 · Cited by 1 · see citing works

QUANTITATIVE STRUCTURE–ACTIVITY RELATIONSHIPS (QSAR) STUDY ON NOVEL 4-AMIDINOQUINOLINE AND 10-AMIDINOBENZONAPHTHYRIDINE DERIVATIVES AS POTENT ANTIMALARIA AGENT

Mahmud, A. W., Shallangwa, G. A., & Uzairu, A. (2019) · The Journal of Engineering and Exact Sciences · doi:10.18540/jcecvl5iss3pp0271-0282 · Cited by 1 · see citing works

Thousands of chemical starting points for antimalarial lead identification

Gamo, F., Sanz, L. M., Vidal, J., de Cózar, C., Álvarez, E. F., Lavandera, J.-L., Vanderwall, D. E., Green, D. V. S., Kumar, V. D., Hasan, S., et al. (2010) · Nature · doi:10.1038/nature09107 · Cited by 991 · see citing works

Chemical genetics of Plasmodium falciparum

Guiguemde, W. A., Shelat, A. A., Bouck, D. C., Duffy, S., Crowther, G. J., Davis, P. H., Smithson, D. C., Connelly, M., Clark, J. A., Zhu, F., et al. (2010) · Nature · doi:10.1038/nature09099 · Cited by 561 · see citing works

Global Phenotypic Screening for Antimalarials

Guiguemde, W. A., Shelat, A. A., Garcia-Bustos, J., Diagana, T. T., Gamo, F., & Guy, R. K. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.01.004 · Cited by 136 · see citing works

Expanding the Antimalarial Drug Arsenal—Now, But How?

Grimberg, B. T., & Mehlotra, R. K. (2011) · Pharmaceuticals · doi:10.3390/ph4050681 · Cited by 57 · see citing works

Searching for New Antimalarial Therapeutics amongst Known Drugs

Weisman, J. L., Liou, A. P., Shelat, A., Cohen, F., Guy, R., & Derisi, J. (2006) · Chemical Biology and Drug Design · doi:10.1111/j.1747-0285.2006.00391.x · Cited by 137 · see citing works