The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Targeting protein kinases in central nervous system disorders
Open accessAbstract
Protein kinases are a growing drug target class in disorders in peripheral tissues, but the development of kinase-targeted therapies for central nervous system (CNS) diseases remains a challenge, largely owing to issues associated specifically with CNS drug discovery. However, several candidate therapeutics that target CNS protein kinases are now in various stages of preclinical and clinical development. We review candidate compounds and discuss selected CNS protein kinases that are emerging as important therapeutic targets. In addition, we analyse trends in small-molecule properties that correlate with key challenges in CNS drug discovery, such as blood–brain barrier penetrance and cytochrome P450-mediated metabolism, and discuss the potential of future approaches that will integrate molecular-fragment expansion with pharmacoinformatics to address these challenges.
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Axonal transport and neurological disease
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Self-citation
Metadata
- Authors
- Chico, L. K., Van Eldik, L. J., & Watterson, D. M.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2009-11
- Volume
- 8
- Issue
- 11
- Pages
- 892-909
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W1964892539
- Cited by
- 298
- References
- 16
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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