The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Adding calorimetric data to decision making in lead discovery: a hot tip
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Citations
Cites
Drug-like properties and the causes of poor solubility and poor permeability
Lipinski, C. A. (2000) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(00)00107-6 · Cited by 3,734
Discovering High-Affinity Ligands for Proteins: SAR by NMR
Shuker, S. B., Hajduk, P. J., Meadows, R. P., & Fesik, S. W. (1996) · Science · doi:10.1126/science.274.5292.1531 · Cited by 2,041
Ligand efficiency: a useful metric for lead selection
Hopkins, A. L., Groom, C. R., & Alex, A. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03069-7 · Cited by 1,846
Coupling of Local Folding to Site-Specific Binding of Proteins to DNA
Spolar, R. S., & Record, M. T. (1994) · Science · doi:10.1126/science.8303294 · Cited by 1,401
Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery
Hann, M. M., Leach, A. R., & Harper, G. (2001) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci000403i · Cited by 877
Rees, D. C., Congreve, Murray, C. W., & Carr, R. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1467 · Cited by 798
Protein Structure and the Energetics of Protein Stability
Robertson, A. D., & Murphy, K. P. (1997) · Chemical Reviews · doi:10.1021/cr960383c · Cited by 679
Ligand efficiency indices as guideposts for drug discovery
Abad-Zapatero, C., & Metz, J. T. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03386-6 · Cited by 527
Ladbury, J. E. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90164-7 · Cited by 520
Self-citationDo enthalpy and entropy distinguish first in class from best in class?
Freire, E. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.07.005 · Cited by 491
Self-citation
Cited by
The role of ligand efficiency metrics in drug discovery
Hopkins, A. L., Keserü, G. M., Leeson, P. D., Rees, D. C., & Reynolds, C. H. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4163 · Cited by 1,181
Entropy-Enthalpy Compensation: Role and Ramifications in Biomolecular Ligand Recognition and Design
Chodera, J. D., & Mobley, D. L. (2013) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-083012-130318 · Cited by 531
Biophysics in drug discovery: impact, challenges and opportunities
Renaud, J.-P., Chung, C.-W., Danielson, U. H., Egner, U., Hennig, M., Hubbard, R. E., & Nar, H. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.123 · Cited by 382
Baum, B., Muley, L., Smolinski, M., Heine, A., Hangauer, D., & Klebe, G. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.02.007 · Cited by 157
Self-citationIncreasing the efficiency of ligands for FK506-binding protein 51 by conformational control
Wang, Y., Kirschner, A., Fabian, A.-K., Gopalakrishnan, R., Kress, C., Hoogeland, B., Koch, U., Kozany, C., Bracher, A., & Hausch, F. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400087k · Cited by 60
Metadata
- Authors
- Ladbury, J. E., Klebe, G., & Freire, E.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2009-12-04
- Volume
- 9
- Issue
- 1
- Pages
- 23-27
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W1981202673
- Cited by
- 398
- References
- 26
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Adding calorimetric data to decision making in lead discovery: a hot tip. https://app.cochat.ai/papers/10.1038/nrd3054
- The paper
- Ladbury, J. E., Klebe, G., & Freire, E. (2010). Adding calorimetric data to decision making in lead discovery: a hot tip. Nature Reviews Drug Discovery. https://doi.org/10.1038/nrd3054
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
