The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
Open accessAbstract
The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has been implicated in disorders such as cancer and inflammatory diseases. This Review discusses the ways in which S1P might be therapeutically targeted — for example, via the development of chemical inhibitors that target the generation, transport and degradation of S1P and via the development of specific S1P receptor agonists. We also highlight recent conflicting results observed in preclinical studies targeting S1P and discuss ongoing clinical trials in this field.
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Cites
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Cited by
Kuswanto, W., Burzyn, D., Panduro, M., Wang, K. K., Jang, Y. C., Wagers, A. J., Benoist, C., & Mathis, D. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.009 · Cited by 517
An update on the biology of sphingosine 1-phosphate receptors
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STAT3 Target Genes Relevant to Human Cancers
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Bioactive Lipids and Chronic Inflammation: Managing the Fire Within
Chiurchiù, V., Leuti, A., & Maccarrone, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00038 · Cited by 427
The Concise Guide to PHARMACOLOGY 2013/14: Enzymes
Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12451 · Cited by 425
Metadata
- Authors
- Kunkel, G. T., Maceyka, M., Milstien, S., & Spiegel, S.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2013-08-19
- Volume
- 12
- Issue
- 9
- Pages
- 688-702
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2070261634
- Cited by
- 434
- References
- 135
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
