The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
Spina bifida
Open accessAbstract
Spina bifida is a birth defect in which the vertebral column is open, often with spinal cord involvement. The most clinically significant subtype is myelomeningocele (open spina bifida), which is a condition characterized by failure of the lumbosacral spinal neural tube to close during embryonic development. The exposed neural tissue degenerates in utero, resulting in neurological deficit that varies with the level of the lesion. Occurring in approximately 1 per 1,000 births worldwide, myelomeningocele is one of the most common congenital malformations, but its cause is largely unknown. The genetic component is estimated at 60–70%, but few causative genes have been identified to date, despite much information from mouse models. Non-genetic maternal risk factors include reduced folate intake, anticonvulsant therapy, diabetes mellitus and obesity. Primary prevention by periconceptional supplementation with folic acid has been demonstrated in clinical trials, leading to food fortification programmes in many countries. Prenatal diagnosis is achieved by ultrasonography, enabling women to seek termination of pregnancy. Individuals who survive to birth have their lesions closed surgically, with subsequent management of associated defects, including the Chiari II brain malformation, hydrocephalus, and urological and orthopaedic sequelae. Fetal surgical repair of myelomeningocele has been associated with improved early neurological outcome compared with postnatal operation. Myelomeningocele affects quality of life during childhood, adolescence and adulthood, posing a challenge for individuals, families and society as a whole. For an illustrated summary of this Primer, visit: http://go.nature.com/fK9XNa
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Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study
(1991) · The Lancet · doi:10.1016/0140-6736(91)90133-a · Cited by 3,472
Czeizel, A. E., & Dudás, I. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212243272602 · Cited by 3,178
A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele
Adzick, N. S., Thom, E. A., Spong, C. Y., Brock, J. W., Burrows, P. K., Johnson, M. P., Howell, L. J., Farrell, J. A., Dabrowiak, M. E., Sutton, L. N., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1014379 · Cited by 2,249
Self-citationSneddon, J., Densem, J. W., Wald, N. J., Frost, C., Stone, R., & Gnant, M. (1991) · PubMed · Cited by 1,812
Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., & Klein, P. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101287200 · Cited by 1,758
Personal omics profiling reveals dynamic molecular and medical phenotypes
Chen, R., Mias, G. I., Li-Pook-Than, J., Jiang, L., Lam, H. Y. K., Chen, R., Miriami, E., Karczewski, K. J., Hariharan, M., Dewey, F. E., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.009 · Cited by 1,291
Stothard, K. J., Tennant, P. W. G., Bell, R., & Rankin, J. (2009) · JAMA · doi:10.1001/jama.2009.113 · Cited by 1,270
Reduction in Neural-Tube Defects after Folic Acid Fortification in Canada
De Wals, P., Tairou, F., Van Allen, M. I., Uh, S.-H., Lowry, R. B., Sibbald, B., Evans, J. A., Van den Hof, M. C., Zimmer, P., Crowley, M., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067103 · Cited by 851
The genetic basis of mammalian neurulation
Copp, A. J., Greene, N. D. E., & Murdoch, J. N. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1181 · Cited by 697
Self-citationThe Prevalence of Congenital Anomalies in Europe
Dolk, H., Loane, M., & Garne, E. (2010) · Advances in Experimental Medicine and Biology · doi:10.1007/978-90-481-9485-8_20 · Cited by 683
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One-Carbon Metabolism in Health and Disease
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Green, R., Allen, L. H., Bjørke-Monsen, A.-L., Brito, A., Guéant, J.-L., Miller, J. W., Molloy, A. M., Nexo, E., Stabler, S., Toh, B.-H., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.40 · Cited by 970
Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation: Commentary
Patel, N., Viguera, A. C., & Baldessarini, R. J. (2018) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000813 · Cited by 23
First Trimester Ultrasound Detection of Fetal Central Nervous System Anomalies
Ungureanu, D. R., Drăgușin, R. C., Căpitănescu, R. G., Zorilă, L., Ofițeru, A. M. I., Marinaș, C., Pătru, C. L., Comănescu, A. C., Comănescu, M. C., Sîrbu, O. C., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13010118 · Cited by 20
Cengizler, Ç., Ün, M. K., & Büyükkurt, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-66468-x · Cited by 11
Metadata
- Authors
- Copp, A. J., Adzick, N. S., Chitty, L. S., Fletcher, J. M., Holmbeck, G. N., & Shaw, G. M.
- Venue
- Nature Reviews Disease Primers
- Published
- 2015-04-30
- Volume
- 1
- Issue
- 1
- Pages
- 15007-15007
- ISSN
- 2056-676X (ISSN-L)
- OpenAlex
- W4210319618
- Cited by
- 649
- References
- 173
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- green
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