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Erectile dysfunction
Open accessAbstract
Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. Roles for nonendocrine (neurogenic, vasculogenic and iatrogenic) and endocrine pathways have been proposed. Owing to its strong association with metabolic syndrome and cardiovascular disease, cardiac assessment may be warranted in men with symptoms of erectile dysfunction. Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices. Surgical therapies are reserved for the subset of patients who have contraindications to these nonsurgical interventions, those who experience adverse effects from (or are refractory to) medical therapy and those who also have penile fibrosis or penile vascular insufficiency. Erectile dysfunction can have deleterious effects on a man's quality of life; most patients have symptoms of depression and anxiety related to sexual performance. These symptoms, in turn, affect his partner's sexual experience and the couple's quality of life. This Primer highlights numerous aspects of erectile dysfunction, summarizes new treatment targets and ongoing preclinical studies that evaluate new pharmacotherapies, and covers the topic of regenerative medicine, which represents the future of sexual medicine.
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“Similar considerations can be made regarding other important causes of ED where the combination of drugs and feelings of inadequacy along with fear and psychological distress due to body image perturbation (eg, obesity) can profoundly negatively affect sexual function and well-being.78”
From A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM) (2021) · cites this paper as [78]
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Metadata
- Authors
- Yafi, F. A., Jenkins, L., Albersen, M., Corona, G., Isidori, A. M., Goldfarb, S., Maggi, M., Nelson, C. J., Parish, S., Salonia, A., Tan, R., Mulhall, J. P., & Hellstrom, W. J. G.
- Affiliations
- Tulane University (US)
- Memorial Sloan Kettering Cancer Center (US)
- KU Leuven (BE)
- Ospedale Bellaria (IT)
- Sapienza University of Rome (IT)
- University of Florence (IT)
- Albert Einstein College of Medicine (US)
- IRCCS Ospedale San Raffaele (IT)
- Tan Tock Seng Hospital (SG)
- Corresponding author
- Mulhall, John P.
- Hellstrom, Wayne J. G.
- ORCID
- Venue
- Nature Reviews Disease Primers
- Published
- 2016-02-04
- Volume
- 2
- Issue
- 1
- Pages
- 16003-16003
- ISSN
- 2056-676X (ISSN-L)
- PMC
- PMC5027992
- OpenAlex
- W4211157510
- Cited by
- 853
- References
- 217
- Citations by year
- 2026: 87 · 2025: 139 · 2024: 134 · 2023: 133 · 2022: 113 · 2021: 98 · 2020: 67 · 2019: 35 · 2018: 33 · 2017: 12
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Reviews Disease Primers (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- National Cancer Institute (P30CA008748)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
- Keywords
- erectile dysfunction, male sexual dysfunction, erectile response, metabolic syndrome, cardiovascular disease, cardiac evaluation, lifestyle modification, intracavernous injection, vacuum erection devices, penile fibrosis, anxiety and depression, quality of life, regenerative medicine, sexual medicine
- MeSH terms
- Aging, Alcohol Drinking, Endocrine System Diseases, Humans, Erectile Dysfunction, Male, Penis, Quality of Life, Risk Factors, Smoking
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