Cited by 853Sexual function and dysfunction studiesUrological Disorders and TreatmentsDupuytren's Contracture and Treatments

The DOI matches its Crossref record; 217 of the 217 references it cites were found in a registry or an index.

Erectile dysfunction

Open access

Yafi, Faysal A., Jenkins, Lawrence, Albersen, Maarten, Corona, Giovanni, Isidori, Andrea M., Goldfarb, Shari, Maggi, Mario, Nelson, Christian J., Parish, Sharon, Salonia, Andrea, Tan, Ronny, Mulhall, John P., Hellstrom, Wayne J. G.·2016·Nature Reviews Disease Primers

DOI 10.1038/nrdp.2016.3PMC PMC5027992

Open this paper in CoChat — free account

Abstract

Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. Roles for nonendocrine (neurogenic, vasculogenic and iatrogenic) and endocrine pathways have been proposed. Owing to its strong association with metabolic syndrome and cardiovascular disease, cardiac assessment may be warranted in men with symptoms of erectile dysfunction. Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices. Surgical therapies are reserved for the subset of patients who have contraindications to these nonsurgical interventions, those who experience adverse effects from (or are refractory to) medical therapy and those who also have penile fibrosis or penile vascular insufficiency. Erectile dysfunction can have deleterious effects on a man's quality of life; most patients have symptoms of depression and anxiety related to sexual performance. These symptoms, in turn, affect his partner's sexual experience and the couple's quality of life. This Primer highlights numerous aspects of erectile dysfunction, summarizes new treatment targets and ongoing preclinical studies that evaluate new pharmacotherapies, and covers the topic of regenerative medicine, which represents the future of sexual medicine.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrdp.2016.3

Cites

217 of 217 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074
Efficacy and Safety of Tadalafil Monotherapy for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Meta-Analysis
Dong, Y., Hao, L., Shi, Z., Wang, G., Zhang, Z., & Han, C. (2013) · Urologia Internationalis · doi:10.1159/000351405 · Cited by 4,557
Organic Causes of Erectile Dysfunction in Men Under 40
Ludwig, W. W., & Phillips, M. (2013) · Urologia Internationalis · doi:10.1159/000354931 · Cited by 2,178
Oral Sildenafil in the Treatment of Erectile Dysfunction
Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382001 · Cited by 2,120
Letter: Grading of angina pectoris.
CAMPEAU, L. A. (1976) · Circulation · doi:10.1161/circ.54.3.947585 · Cited by 1,607
Sexual problems among women and men aged 40–80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors
Laumann, E. O., Nicolosi, A., Glasser, D. B., Paik, A., Gingell, C., Moreira, E., Wang, T., & for the GSSAB Investigators' Group (2005) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901250 · Cited by 1,415
Erectile Dysfunction
Lue, T. F. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006153422407 · Cited by 1,267
Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation
Hatzimouratidis, K., Amar, E., Eardley, I., Giuliano, F., Hatzichristou, D., Montorsi, F., Vardi, Y., & Wespes, E. (2010) · European Urology · doi:10.1016/j.eururo.2010.02.020 · Cited by 1,223
INCIDENCE OF ERECTILE DYSFUNCTION IN MEN 40 TO 69 YEARS OLD: LONGITUDINAL RESULTS FROM THE MASSACHUSETTS MALE AGING STUDY
JOHANNES, C. B., ARAUJO, A. B., FELDMAN, H. A., DERBY, C. A., KLEINMAN, K. P., & McKINLAY, J. B. (2000) · Journal of Urology · doi:10.1016/s0022-5347(05)67900-1 · Cited by 1,158
Physiology of penile erection
Andersson, K. E., & Wagner, G. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.1.191 · Cited by 1,119

Show all 217 references

Sorted by citations

European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction
Salonia, A., Bettocchi, C., Boeri, L., Capogrosso, P., Carvalho, J., Çilesiz, N. C., Cocci, A., Corona, G., Dimitropoulos, K., Gül, M., et al. (2021) · European Urology · doi:10.1016/j.eururo.2021.06.007 · Cited by 858
Sexual dysfunction and male infertility
Lotti, F., & Maggi, M. (2018) · Nature Reviews Urology · doi:10.1038/nrurol.2018.20 · Cited by 363
Erectile Dysfunction in Young Men—A Review of the Prevalence and Risk Factors
Nguyen, H. M. T., Gabrielson, A. T., & Hellstrom, W. J. G. (2017) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.05.004 · Cited by 363
Erectile dysfunction and diabetes: A melting pot of circumstances and treatments
Defeudis, G., Mazzilli, R., Tenuta, M., Rossini, G., Zamponi, V., Olana, S., Faggiano, A., Pozzilli, P., Isidori, A. M., & Gianfrilli, D. (2021) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3494 · Cited by 310
Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities
Kumar, M., Barbhai, M. D., Hasan, M., Punia, S., Dhumal, S., Radha, Rais, N., Chandran, D., Pandiselvam, R., Kothakota, A., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112498 · Cited by 240
Addressing male sexual and reproductive health in the wake of COVID-19 outbreak
Sansone, A., Mollaioli, D., Ciocca, G., Limoncin, E., Colonnello, E., Vena, W., & Jannini, E. A. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01350-1 · Cited by 170
Interactions between erectile dysfunction, cardiovascular disease and cardiovascular drugs
Terentes-Printzios, D. G., Ioakeimidis, N., Rokkas, K., & Vlachopoulos, C. V. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00593-6 · Cited by 172
Global Research Trends on Prostate Diseases and Erectile Dysfunction: A Bibliometric and Visualized Study
Ma, C., Su, H., & Li, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.627891 · Cited by 149
Estimating the Prevalence of Sexual Dysfunction Using the New ICD-11 Guidelines
Briken, P., Matthiesen, S., Pietras, L., Wiessner, C., Klein, V., Reed, G. M., & Dekker, A. (2020) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2020.0653 · Cited by 145
Sexual Health Implications of COVID-19 Pandemic
Pennanen-Iire, C., Prereira-Lourenço, M., Padoa, A., Ribeirinho, A., Samico, A., Gressler, M., Jatoi, N.-A., Mehrad, M., & Girard, A. (2020) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2020.10.004 · Cited by 160
The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction
Corona, G., Cucinotta, D., Lorenzo, G. D., Ferlin, A., Giagulli, V. A., Gnessi, L., Isidori, A. M., Maiorino, M. I., Miserendino, P., Murrone, A., et al. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02015-5 · Cited by 127
Erectile dysfunction in fit and healthy young men: psychological or pathological?
Rastrelli, G., & Maggi, M. (2017) · Translational Andrology and Urology · doi:10.21037/tau.2016.09.06 · Cited by 125
Transplantation of adipose tissue-derived stem cell-derived exosomes ameliorates erectile function in diabetic rats
Zhu, L., Huang, X., Yu, W., Chen, H., Chen, Y., & Dai, Y. (2017) · Andrologia · doi:10.1111/and.12871 · Cited by 120
Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction
Roychoudhury, S., Chakraborty, S., Choudhury, A. P., Das, A., Jha, N. K., Sláma, P., Nath, M., Massányi, P., Ruokolainen, J., & Kesari, K. K. (2021) · Antioxidants · doi:10.3390/antiox10060837 · Cited by 132
GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology
Bovijn, J., Jackson, L. M., Censin, J. C., Chen, C., Laisk, T., Laber, S., Ferreira, T. C., Pulit, S. L., Glastonbury, C. A., Smoller, J. W., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.11.004 · Cited by 114
Management of male erectile dysfunction: From the past to the future
Wang, C., Wu, B.-R., Xiang, P., Xiao, J., & Hu, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1148834 · Cited by 108
Platelet-Rich Plasma (PRP) Improves Erectile Function: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Poulios, E., Mykoniatis, I., Pyrgidis, N., Zilotis, F., Kapoteli, P., Kotsiris, D., Kalyvianakis, D., & Hatzichristou, D. (2021) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2021.03.008 · Cited by 105
Update on the Safety of Phosphodiesterase Type 5 Inhibitors for the Treatment of Erectile Dysfunction
Yafi, F. A., Sharlip, I. D., & Becher, E. F. (2017) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.08.001 · Cited by 102
A genome-wide association study to identify candidate genes for erectile dysfunction
Kazemi, E., Zargooshi, J., Kaboudi, M., Heidari, P., Kahrizi, D., Mahaki, B., Mohammadian, Y., Khazaei, H., & Ahmed, K. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa338 · Cited by 102
Sexual Rehabilitation After Treatment For Prostate Cancer—Part 2: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015)
Salonia, A., Adaikan, G., Buvat, J., Carrier, S., El-Meliegy, A., Hatzimouratidis, K., McCullough, A., Morgentaler, A., Torres, L. O., & Khera, M. (2017) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.11.324 · Cited by 102
“Mask up to keep it up”: Preliminary evidence of the association between erectile dysfunction and COVID‐19
Sansone, A., Mollaioli, D., Ciocca, G., Colonnello, E., Limoncin, E., Balercia, G., & Jannini, E. A. (2021) · Andrology · doi:10.1111/andr.13003 · Cited by 103
Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis
Feng, H., Liu, Q., Deng, Z., Li, H., Zhang, H., Song, J., Liu, X., Liu, J., Wen, B., & Wang, T. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03147-w · Cited by 101
A Psychosocial Approach to Erectile Dysfunction: Position Statements from the European Society of Sexual Medicine (ESSM)
Dewitte, M., Bettocchi, C., Carvalho, J., Corona, G., Flink, I., Limoncin, E., Pascoal, P., Reisman, Y., & Van Lankveld, J. (2021) · Sexual Medicine · doi:10.1016/j.esxm.2021.100434 · Cited by 97
Insights into modifiable risk factors of erectile dysfunction, a wide-angled Mendelian Randomization study
Xiong, Y., Zhang, F., Zhang, Y., Wang, W., Ran, Y., Wu, C., Zhu, S., Qin, F., & Yuan, J. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.05.008 · Cited by 96
The role of testosterone in male sexual function
Corona, G., & Maggi, M. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09748-3 · Cited by 100
The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications
Maiuolo, J., Gliozzi, M., Musolino, V., Carresi, C., Nucera, S., Macrì, R., Scicchitano, M., Bosco, F., Scarano, F., Ruga, S., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123022 · Cited by 87
Etiology of Male Infertility: an Update
Bhattacharya, I., Sharma, S. S., & Majumdar, S. (2023) · Reproductive Sciences · doi:10.1007/s43032-023-01401-x · Cited by 81
Novel Emerging Therapies for Erectile Dysfunction
Kim, S., Cho, M. C., Cho, S. Y., Chung, H., & Rajasekaran, M. R. (2020) · The World Journal of Men s Health · doi:10.5534/wjmh.200007 · Cited by 82
Erectile Dysfunction Is a Hallmark of Cardiovascular Disease: Unavoidable Matter of Fact or Opportunity to Improve Men’s Health?
Yannas, D., Frizza, F., Vignozzi, L., Corona, G., Maggi, M., & Rastrelli, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102221 · Cited by 68
Sexual Rehabilitation After Treatment for Prostate Cancer—Part 1: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015)
Salonia, A., Adaikan, G., Buvat, J., A., C. S., El-Meliegy, A., Hatzimouratidis, K., McCullough, A., Morgentaler, A., Torres, L. O., & Khera, M. (2017) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.11.325 · Cited by 71
The mechanisms and potential of stem cell therapy for penile fibrosis
Milenković, U., Albersen, M., & Castiglione, F. (2018) · Nature Reviews Urology · doi:10.1038/s41585-018-0109-7 · Cited by 70
Effects of Environmental and Pathological Hypoxia on Male Fertility
Li, Z., Wang, S., Gong, C., Hu, Y., Liu, J., Wang, W., Chen, Y., Liao, Q., He, B., Huang, Y., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.725933 · Cited by 70
The Sexual Long COVID (SLC): Erectile Dysfunction as a Biomarker of Systemic Complications for COVID-19 Long Haulers
Sansone, A., Mollaioli, D., Limoncin, E., Ciocca, G., Bắc, N. H., Thắng, N. C., Hou, G., Yuan, J., Zitzmann, M., Giraldi, A. G. E., et al. (2021) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2021.11.001 · Cited by 72
Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis
Pizzol, D., Demurtas, J., Stubbs, B., Soysal, P., Mason, C., Işık, A. T., Solmi, M., Smith, L., & Veronese, N. (2019) · American Journal of Men s Health · doi:10.1177/1557988319892464 · Cited by 68
Penile Doppler Ultrasound for Erectile Dysfunction: Technique and Interpretation
Varela, C. G., Yeguas, L. M., Rodríguez, I. C., & Vila, M. D. D. (2020) · American Journal of Roentgenology · doi:10.2214/ajr.19.22141 · Cited by 66
Reproductive axis ageing and fertility in men
da Silva, S. M., & Anderson, R. A. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09759-0 · Cited by 72
Male sexual dysfunction
Anderson, D., Laforge, J., M. Ross, M., Vanlangendonck, R., Hasoon, J., Viswanath, O., D. Kaye, A., & Urits, I. (2022) · Health Psychology Research · doi:10.52965/001c.37533 · Cited by 66
Sexual Quality of Life and Satisfaction With Penile Prostheses
Barton, G. J., Carlos, E. C., & Lentz, A. (2018) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2018.10.003 · Cited by 65
Nanotechnology in reproductive medicine: Opportunities for clinical translation
Shandilya, R., Pathak, N., Lohiya, N. K., Sharma, R. S., & Mishra, P. K. (2020) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2020.03650 · Cited by 61
Mindfulness-based group therapy for men with situational erectile dysfunction: A mixed-methods feasibility analysis and pilot study
Bossio, J. A., Basson, R., Driscoll, M., Correia, S., & Brotto, L. A. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.08.013 · Cited by 60
A review on the stem cell therapy and an introduction to exosomes as a new tool in reproductive medicine
Kharazi, U., & Badalzadeh, R. (2020) · Reproductive Biology · doi:10.1016/j.repbio.2020.07.002 · Cited by 58
Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach
Palanichamy, C., Pavadai, P., Theivendren, P., Arunachalam, S., Babkiewicz, E., Pandian, S. R. K., Kabilan, S. J., Ammunje, D. N., Suthendran, K., Chandrasekaran, J., et al. (2022) · Molecules · doi:10.3390/molecules27123799 · Cited by 59
Impact of hypoxia on male reproductive functions
Oyedokun, P. A., Akhigbe, R. E., Ajayi, L. O., & Ajayi, A. F. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04559-1 · Cited by 58
Erectile Dysfunction: Key Role of Cavernous Smooth Muscle Cells
de Souza, I. L. L., Ferreira, E. D. S., Vasconcelos, L. H. C., Cavalcante, F. D. A., & da Silva, B. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.895044 · Cited by 57
Relationship between weight-adjusted-waist index and erectile dysfunction in the United State: results from NHANES 2001-2004
Cao, S., Hu, X., Shao, Y., Wang, Y., Tang, Y., Ren, S., & Li, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1128076 · Cited by 56
An In-Depth Bibliometric Analysis and Current Perspective on Male infertility Research
Baskaran, S., Agarwal, A. K., Leisegang, K., Pushparaj, P. N., Selvam, M. K. P., & Henkel, R. (2019) · The World Journal of Men s Health · doi:10.5534/wjmh.180114 · Cited by 57
Promising role of medicinal plants in the regulation and management of male erectile dysfunction
Masuku, N. P., Unuofin, J. O., & Lebelo, S. L. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110555 · Cited by 58
HIV and Sexual Dysfunction in Men
Vincentis, S. D., Tartaro, G., Rochira, V., & Santi, D. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051088 · Cited by 61
The Prevalence of Lower Limb and Genital Lymphedema after Prostate Cancer Treatment: A Systematic Review
Clinckaert, A., Callens, K., Cooreman, A., Bijnens, A., Moris, L., Calster, C. V., Geraerts, I., Joniau, S., & Everaerts, W. (2022) · Cancers · doi:10.3390/cancers14225667 · Cited by 55
LIPUS‐SCs‐Exo promotes peripheral nerve regeneration in cavernous nerve crush injury‐induced ED rats via PI3K /Akt/ FoxO signaling pathway
Ye, K., Li, Z., Yin, Y., Zhou, J., Li, D., Gan, Y., Peng, D., Xiao, M., Zhao, L., Dai, Y., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14256 · Cited by 55
Erectile Dysfunction: Treatments, Advances and New Therapeutic Strategies
Argiolas, A., Argiolas, F. M., Argiolas, G., & Melis, M. R. (2023) · Brain Sciences · doi:10.3390/brainsci13050802 · Cited by 63
Hydrogel forming microneedle-mediated transdermal delivery of sildenafil citrate from polyethylene glycol reservoir: An ex vivo proof of concept study
Elim, D., Fitri, A. M. N., Mahfud, M. A. S., Afika, N., Sultan, N. A. F., Hijrah, Asri, R. M., & Permana, A. D. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.113018 · Cited by 54
Low-Intensity Shockwave Therapy for Erectile Dysfunction: A Randomized Clinical Trial Comparing 2 Treatment Protocols and the Impact of Repeating Treatment
Kalyvianakis, D., Memmos, E., Mykoniatis, I., Kapoteli, P., Memmos, D., & Hatzichristou, D. G. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.01.003 · Cited by 54
Implications of Exposure to Air Pollution on Male Reproduction: The Role of Oxidative Stress
Omolaoye, T. S., Skosana, B. T., Ferguson, L. M., Ramsunder, Y., Ayad, B. M., & du Plessis, S. S. (2024) · Antioxidants · doi:10.3390/antiox13010064 · Cited by 53
Is Platelet Rich Plasma Safe and Effective in Treatment of Erectile Dysfunction? Randomized Controlled Study
Shaher, H., Fathi, A., Elbashir, S., Abdelbaki, S. A., & Soliman, T. T. (2023) · Urology · doi:10.1016/j.urology.2023.01.028 · Cited by 52
Neuroprotective and Nerve Regenerative Approaches for Treatment of Erectile Dysfunction after Cavernous Nerve Injury
Campbell, J. D., & Burnett, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081794 · Cited by 54
Sildenafil beyond erectile dysfunction and pulmonary arterial hypertension: Thinking about new indications
Ala, M., Jafari, R. M., & Dehpour, A. R. (2020) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12633 · Cited by 52
Erectile Dysfunction and Oxidative Stress: A Narrative Review
Zhu, D., Pham, Q. M., Wang, C., Colonnello, E., Yannas, D., Hoai, B. N., Zhang, Y., Jannini, E. A., & Sansone, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073073 · Cited by 53
Sexual impairment in patients with hidradenitis suppurativa: a systematic review
Cuenca‐Barrales, C., Montero‐Vílchez, T., Szepietowski, J. C., Matusiak, Ł., & Molina‐Leyva, A. (2020) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16726 · Cited by 48
Anatomy and Physiology of the Hypothalamic-Pituitary-Gonadal (HPG) Axis
Dwyer, A. A., & Quinton, R. (2019) · Springer eBooks · doi:10.1007/978-3-319-99817-6_43 · Cited by 56
Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review
Leisegang, K., & Finelli, R. (2021) · Arab Journal of Urology · doi:10.1080/2090598x.2021.1926753 · Cited by 47
The Psychology of Erectile Dysfunction
Allen, M. S., Wood, A. M., & Sheffield, D. (2023) · Current Directions in Psychological Science · doi:10.1177/09637214231192269 · Cited by 49
GPX4 Alleviates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting Ferroptosis
Xu, W., Sun, T., Wang, J., Wang, T., Wang, S., Liu, J., & Li, H. (2022) · Antioxidants · doi:10.3390/antiox11101896 · Cited by 45
Vasculogenic Erectile Dysfunction: The Impact of Diet and Lifestyle
Ostfeld, R. J., Allen, K., Aspry, K. E., Brandt, E. J., Spitz, A., Liberman, J. N., Belardo, D., O’Keefe, J. H., Aggarwal, M., Miller, M. J., et al. (2020) · The American Journal of Medicine · doi:10.1016/j.amjmed.2020.09.033 · Cited by 53
Primary organic versus primary psychogenic erectile dysfunction: Findings from a real‐life cross‐sectional study
Pozzi, E., Fallara, G., Capogrosso, P., Boeri, L., Belladelli, F., Corsini, C., da Costa, A. G., Candela, L., Cignoli, D., Cazzaniga, W., et al. (2022) · Andrology · doi:10.1111/andr.13212 · Cited by 43
Factors associated with anxiety and depression in patients with erectile dysfunction: a cross-sectional study
Xiao, Y., Xie, T., Peng, J., Zhou, X., Long, J., Yang, M., Zhu, H., & Yang, J. Y. (2023) · BMC Psychology · doi:10.1186/s40359-023-01074-w · Cited by 48
Erectile dysfunction in cirrhosis is impacted by liver dysfunction, portal hypertension, diabetes and arterial hypertension
Paternostro, R., Heinisch, B. B., Reiberger, T., Mandorfer, M., Schwarzer, R., Seeland, B., Trauner, M. A., Peck‐Radosavljevic, M., & Ferlitsch, A. (2018) · Liver International · doi:10.1111/liv.13704 · Cited by 43
A Mitochondrion‐Targeting Piezoelectric Nanosystem for the Treatment of Erectile Dysfunction via Autophagy Regulation
Wang, S., Wang, Z., Zang, Z., Liang, X., Jia, B., Tan, Y., Lan, Y., & Shi, X. (2024) · Advanced Materials · doi:10.1002/adma.202413287 · Cited by 42
Current and future trends in men’s health clinics
Houman, J., Eleswarapu, S. V., & Mills, J. N. (2020) · Translational Andrology and Urology · doi:10.21037/tau.2019.08.33 · Cited by 41
The 2018 Revision to the Process of Care Model for Evaluation of Erectile Dysfunction
Mulhall, J. P., Giraldi, A., Hackett, G., Hellstrom, W. J. G., Jannini, E. A., Rubio-Aurioles, E., Trost, L., & Hassan, T. A. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.06.005 · Cited by 40
Male Obesity Associated Gonadal Dysfunction and the Role of Bariatric Surgery
Sultan, S., Patel, A. G., El-Hassani, S., Whitelaw, B., Leca, B. M., Vincent, R. P., le Roux, C. W., Rubino, F., Aywlin, S. J. B., & Dimitriadis, G. K. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00408 · Cited by 39
The relationship between obstructive sleep apnoea and erectile dysfunction: An underdiagnosed link? A prospective cross‐sectional study
Cantone, E., Massanova, M., Crocetto, F., Barone, B., Esposito, F., Arcaniolo, D., Corlianò, F., Romano, L., Motta, G., & Celia, A. (2022) · Andrologia · doi:10.1111/and.14504 · Cited by 36
Assessing ChatGPT’s ability to answer questions pertaining to erectile dysfunction: can our patients trust it?
Razdan, S., Siegal, A. R., Brewer, Y., Sljivich, M., & Valenzuela, R. J. (2023) · International Journal of Impotence Research · doi:10.1038/s41443-023-00797-z · Cited by 38
The association of erectile dysfunction with productivity and absenteeism in eight countries globally
Goldstein, I., Goren, A., Li, V. W., Maculaitis, M. C., Tang, W. Y., & Hassan, T. A. (2019) · International Journal of Clinical Practice · doi:10.1111/ijcp.13384 · Cited by 42
Harm Reduction in Sexual Medicine
Sansone, A., Limoncin, E., Colonnello, E., Mollaioli, D., Ciocca, G., Corona, G., & Jannini, E. A. (2021) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2021.01.005 · Cited by 37
Corpora cavernosa fibroblasts mediate penile erection
Guimarães, E. L. M., Dias, D. O., Hau, W. F., Julien, A., Holl, D., Garcia-Collado, M., Savant, S., Vågesjö, E., Phillipson, M., Jakobsson, L., et al. (2024) · Science · doi:10.1126/science.ade8064 · Cited by 39
Facing Counterfeit Medications in Sexual Medicine. A Systematic Scoping Review on Social Strategies and Technological Solutions
Sansone, A., Cuzin, B., & Jannini, E. A. (2021) · Sexual Medicine · doi:10.1016/j.esxm.2021.100437 · Cited by 35
Increased odds ratio for erectile dysfunction in COVID-19 patients
Katz, J., Yue, S., Xue, W., & Gao, H. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01717-y · Cited by 37
Cigarette smoking and erectile dysfunction: an updated review with a focus on pathophysiology, e-cigarettes, and smoking cessation
Allen, M. S., & Tostes, R. C. (2023) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeac007 · Cited by 34
Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions
dos Reis, F. M., & dos Reis, A. M. (2020) · Clinical Science · doi:10.1042/cs20200865 · Cited by 34
Safety and efficacy of botulinum neurotoxin in the treatment of erectile dysfunction refractory to phosphodiesterase inhibitors: Results of a randomized controlled trial
Abdelrahman, I. F. S., Raheem, A. A., Elkhiat, Y., Aburahma, A. A., Abdel-Raheem, T. M., & Ghanem, H. M. (2021) · Andrology · doi:10.1111/andr.13104 · Cited by 33
Longitudinal Risk of Developing Cardiovascular Diseases in Patients with Erectile Dysfunction—Which Patients Deserve More Attention?
Pozzi, E., Capogrosso, P., Boeri, L., Belladelli, F., Baudo, A., Schifano, N., Abbate, C., Dehò, F., Montorsi, F., & Salonia, A. (2020) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2020.03.012 · Cited by 33
A Critical Analysis of Methodology Pitfalls in Duplex Doppler Ultrasound in the Evaluation of Patients with Erectile Dysfunction: Technical and Interpretation Deficiencies
Nascimento, B., Miranda, E., Terrier, J., Carneiro, F., & Mulhall, J. P. (2020) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2020.05.023 · Cited by 33
Erectile dysfunction: Is platelet-rich plasma the new frontier for treatment in patients with erectile dysfunction? A review of the existing evidence
Anastasiadis, E., Ahmed, R., Khoja, A. K., & Yap, T. (2022) · Frontiers in Reproductive Health · doi:10.3389/frph.2022.944765 · Cited by 34
Etiology of Erectile Dysfunction and Duration of Symptoms in Patients Undergoing Penile Prosthesis: A Systematic Review
Bajic, P., Mahon, J., Faraday, M. M., Sadeghi‐Nejad, H., Hakim, L., & McVary, K. T. (2019) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2019.05.003 · Cited by 32
Serum Homocysteine Levels in Men with and without Erectile Dysfunction: A Systematic Review and Meta-Analysis
Sansone, A., Cignarelli, A., Sansone, M., Romanelli, F., Corona, G., Gianfrilli, D., Isidori, A. M., Giorgino, F., & Lenzi, A. (2018) · International Journal of Endocrinology · doi:10.1155/2018/7424792 · Cited by 32
Exploring the Multifaceted Potential of Sildenafil in Medicine
Pușcașu, C., Zanfirescu, A., Negreș, S., & Șeremet, O. C. (2023) · Medicina · doi:10.3390/medicina59122190 · Cited by 31
Placebo Responses Among Men With Erectile Dysfunction Enrolled in Phosphodiesterase 5 Inhibitor Trials
Stridh, A., Pontén, M., Arver, S., Kirsch, I., Abé, C., & Jensen, K. B. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.1423 · Cited by 32
Epidemiology and Treatment Barriers of Patients With Erectile Dysfunction Using an Online Prescription Platform: A Cross-Sectional Study
Rodler, S., von Büren, J., Büchner, A., Stief, C. G., Elkhanova, K., Wülfing, C., & Jungmann, S. (2020) · Sexual Medicine · doi:10.1016/j.esxm.2020.04.001 · Cited by 36
Relationship between hyperuricemia with deposition and sexual dysfunction in males and females
Sansone, A., Reisman, Y., & Jannini, E. A. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01719-w · Cited by 32
A 6-month, double-blind, placebo-controlled, randomized trial to evaluate the effect of Eurycoma longifolia (Tongkat Ali) and concurrent training on erectile function and testosterone levels in androgen deficiency of aging males (ADAM)
Leitão, A. E., Vieira, M. C. D. S., Pelegrini, A., da Silva, E. L., & Guimarães, A. C. D. A. (2021) · Maturitas · doi:10.1016/j.maturitas.2020.12.002 · Cited by 30
Ferroptosis is involved in corpus cavernosum smooth muscle cells impairment in diabetes mellitus‐induced erectile dysfunction
Xu, W., Sun, T., Wang, J., Wang, T., Wang, S., Liu, J., Liu, K., & Li, H. (2022) · Andrology · doi:10.1111/andr.13291 · Cited by 29
Risk of Erectile Dysfunction After Traumatic Brain Injury: A Nationwide Population-Based Cohort study in Taiwan
Yang, Y., Chien, W., Chung, C., Hong, K.-T., Yu, Y.-L., Hueng, D., Chen, Y.-H., Ma, H., Chang, H., Kao, Y., et al. (2018) · American Journal of Men s Health · doi:10.1177/1557988317750970 · Cited by 29
Enhanced Dissolution of Sildenafil Citrate Using Solid Dispersion with Hydrophilic Polymers: Physicochemical Characterization and In Vivo Sexual Behavior Studies in Male Rats
Aldawsari, M. F., Anwer, M. K., Ahmed, M. M., Fatima, F., Soliman, G. A., Bhatia, S., Zafar, A., & Aboudzadeh, M. A. (2021) · Polymers · doi:10.3390/polym13203512 · Cited by 30
Efficacy of a cultured conditioned medium of exfoliated deciduous dental pulp stem cells in erectile dysfunction patients
Koga, S., & Horiguchi, Y. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17072 · Cited by 30
The association between Parkinson’s disease and Sexual dysfunction: Clinical correlation and therapeutic implications
Ng, Y.-F., Chen, C. Y.-T., Chia, G. T.-H., Tan, B. B. J.-W., Chan, L. L., & Tan, E. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101665 · Cited by 30
Different levels of estradiol are correlated with sexual dysfunction in adult men
Chen, T., Wu, F., Wang, X., Ma, G., Xuan, X., Tang, R., Ding, S., & Lü, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-69712-6 · Cited by 31
Administration of H2S improves erectile dysfunction by inhibiting phenotypic modulation of corpus cavernosum smooth muscle in bilateral cavernous nerve injury rats
Qinyu-Zeng, Shuhua-He, Fengzhi-Chen, LiWang, Liren-Zhong, Hui, J., Wei-Ding, Junhong-Fan, Haibo-Zhang, & Anyang-Wei (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.11.003 · Cited by 29
D-(+)-Galactose-induced aging: A novel experimental model of erectile dysfunction
Rezende, M. S. D. A., de Almeida, A. J. P. O., Gonçalves, T. A. F., de Azevedo, F. D. L. A. A., Dantas, S. H., Silva, S. D. L., Soares, E. M. C., Alves, H. F., Lima, T. T., Júnior, J. F. D. S., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249487 · Cited by 33
Ginseng for erectile dysfunction
Lee, H. W., Lee, M. S., Kim, T., Alræk, T., Zaslawski, C., Kim, J. W., & Moon, D. G. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012654.pub2 · Cited by 29

Authors: Yafi, F. A., Jenkins, L., Albersen, M., Corona, G., Isidori, A. M., Goldfarb, S., Maggi, M., Nelson, C. J., Parish, S., Salonia, A., Tan, R., Mulhall, J. P., & Hellstrom, W. J. G.
Affiliations: Tulane University (US)
Memorial Sloan Kettering Cancer Center (US)
KU Leuven (BE)
Ospedale Bellaria (IT)
Sapienza University of Rome (IT)
University of Florence (IT)
Albert Einstein College of Medicine (US)
IRCCS Ospedale San Raffaele (IT)
Tan Tock Seng Hospital (SG)
Corresponding author: Mulhall, John P.
Hellstrom, Wayne J. G.
ORCID: Yafi, Faysal A.
Jenkins, Lawrence
Albersen, Maarten
Corona, Giovanni
Isidori, Andrea M.
Maggi, Mario
Nelson, Christian J.
Parish, Sharon
Salonia, Andrea
Tan, Ronny
Mulhall, John P.
Hellstrom, Wayne J. G.
Venue: Nature Reviews Disease Primers
Publisher: Springer Science and Business Media LLC
Published: 2016-02-04
Volume: 2
Issue: 1
Pages: 16003-16003
ISSN: 2056-676X (ISSN-L)
DOI: 10.1038/nrdp.2016.3
PMC: PMC5027992
OpenAlex: W4211157510
Cited by: 853
References: 217
Citations by year: 2026: 87 · 2025: 139 · 2024: 134 · 2023: 133 · 2022: 113 · 2021: 98 · 2020: 67 · 2019: 35 · 2018: 33 · 2017: 12
FWCI: 3.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Disease Primers (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Funders: National Cancer Institute (P30CA008748)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
Keywords: erectile dysfunction, male sexual dysfunction, erectile response, metabolic syndrome, cardiovascular disease, cardiac evaluation, lifestyle modification, intracavernous injection, vacuum erection devices, penile fibrosis, anxiety and depression, quality of life, regenerative medicine, sexual medicine
MeSH terms: Aging, Alcohol Drinking, Endocrine System Diseases, Humans, Erectile Dysfunction, Male, Penis, Quality of Life, Risk Factors, Smoking

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Erectile dysfunction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks