Cited by 853Sexual function and dysfunction studiesUrological Disorders and TreatmentsDupuytren's Contracture and Treatments

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Erectile dysfunction

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Yafi, Faysal A., Jenkins, Lawrence, Albersen, Maarten, Corona, Giovanni, Isidori, Andrea M., Goldfarb, Shari, Maggi, Mario, Nelson, Christian J., Parish, Sharon, Salonia, Andrea, Tan, Ronny, Mulhall, John P., Hellstrom, Wayne J. G.·2016·Nature Reviews Disease Primers

DOI 10.1038/nrdp.2016.3PMC PMC5027992

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Abstract

Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. Roles for nonendocrine (neurogenic, vasculogenic and iatrogenic) and endocrine pathways have been proposed. Owing to its strong association with metabolic syndrome and cardiovascular disease, cardiac assessment may be warranted in men with symptoms of erectile dysfunction. Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices. Surgical therapies are reserved for the subset of patients who have contraindications to these nonsurgical interventions, those who experience adverse effects from (or are refractory to) medical therapy and those who also have penile fibrosis or penile vascular insufficiency. Erectile dysfunction can have deleterious effects on a man's quality of life; most patients have symptoms of depression and anxiety related to sexual performance. These symptoms, in turn, affect his partner's sexual experience and the couple's quality of life. This Primer highlights numerous aspects of erectile dysfunction, summarizes new treatment targets and ongoing preclinical studies that evaluate new pharmacotherapies, and covers the topic of regenerative medicine, which represents the future of sexual medicine.

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Authors: Yafi, F. A., Jenkins, L., Albersen, M., Corona, G., Isidori, A. M., Goldfarb, S., Maggi, M., Nelson, C. J., Parish, S., Salonia, A., Tan, R., Mulhall, J. P., & Hellstrom, W. J. G.
Affiliations: Tulane University (US)
Memorial Sloan Kettering Cancer Center (US)
KU Leuven (BE)
Ospedale Bellaria (IT)
Sapienza University of Rome (IT)
University of Florence (IT)
Albert Einstein College of Medicine (US)
IRCCS Ospedale San Raffaele (IT)
Tan Tock Seng Hospital (SG)
Corresponding author: Mulhall, John P.
Hellstrom, Wayne J. G.
ORCID: Yafi, Faysal A.
Jenkins, Lawrence
Albersen, Maarten
Corona, Giovanni
Isidori, Andrea M.
Maggi, Mario
Nelson, Christian J.
Parish, Sharon
Salonia, Andrea
Tan, Ronny
Mulhall, John P.
Hellstrom, Wayne J. G.
Venue: Nature Reviews Disease Primers
Publisher: Springer Science and Business Media LLC
Published: 2016-02-04
Volume: 2
Issue: 1
Pages: 16003-16003
ISSN: 2056-676X (ISSN-L)
DOI: 10.1038/nrdp.2016.3
PMC: PMC5027992
OpenAlex: W4211157510
Cited by: 853
References: 217
Citations by year: 2026: 87 · 2025: 139 · 2024: 134 · 2023: 133 · 2022: 113 · 2021: 98 · 2020: 67 · 2019: 35 · 2018: 33 · 2017: 12
FWCI: 3.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Disease Primers (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Funders: National Cancer Institute (P30CA008748)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
Keywords: erectile dysfunction, male sexual dysfunction, erectile response, metabolic syndrome, cardiovascular disease, cardiac evaluation, lifestyle modification, intracavernous injection, vacuum erection devices, penile fibrosis, anxiety and depression, quality of life, regenerative medicine, sexual medicine
MeSH terms: Aging, Alcohol Drinking, Endocrine System Diseases, Humans, Erectile Dysfunction, Male, Penis, Quality of Life, Risk Factors, Smoking

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