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Cited by 577

The DOI matches its Crossref record; 191 of the 191 references it cites were found in a registry or an index.

Otitis media

Open access
Schilder, Anne G. M., Chonmaitree, Tasnee, Cripps, Allan W., Rosenfeld, Richard M., Casselbrant, Margaretha L., Haggard, Mark P., Venekamp, Roderick P.·2016·Nature Reviews Disease Primers

Abstract

Otitis media (OM) or middle ear inflammation is a spectrum of diseases, including acute otitis media (AOM), otitis media with effusion (OME; ‘glue ear’) and chronic suppurative otitis media (CSOM). OM is among the most common diseases in young children worldwide. Although OM may resolve spontaneously without complications, it can be associated with hearing loss and life-long sequelae. In developing countries, CSOM is a leading cause of hearing loss. OM can be of bacterial or viral origin; during ‘colds’, viruses can ascend through the Eustachian tube to the middle ear and pave the way for bacterial otopathogens that reside in the nasopharynx. Diagnosis depends on typical signs and symptoms, such as acute ear pain and bulging of the tympanic membrane (eardrum) for AOM and hearing loss for OME; diagnostic modalities include (pneumatic) otoscopy, tympanometry and audiometry. Symptomatic management of ear pain and fever is the mainstay of AOM treatment, reserving antibiotics for children with severe, persistent or recurrent infections. Management of OME largely consists of watchful waiting, with ventilation (tympanostomy) tubes primarily for children with chronic effusions and hearing loss, developmental delays or learning difficulties. The role of hearing aids to alleviate symptoms of hearing loss in the management of OME needs further study. Insertion of ventilation tubes and adenoidectomy are common operations for recurrent AOM to prevent recurrences, but their effectiveness is still debated. Despite reports of a decline in the incidence of OM over the past decade, attributed to the implementation of clinical guidelines that promote accurate diagnosis and judicious use of antibiotics and to pneumococcal conjugate vaccination, OM continues to be a leading cause for medical consultation, antibiotic prescription and surgery in high-income countries.

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Metadata

Authors
Schilder, A. G. M., Chonmaitree, T., Cripps, A. W., Rosenfeld, R. M., Casselbrant, M. L., Haggard, M. P., & Venekamp, R. P.
Venue
Nature Reviews Disease Primers
Published
2016-09-08
Volume
2
Issue
1
Pages
16063-16063
ISSN
2056-676X (ISSN-L)
OpenAlex
W4211248544
Cited by
577
References
191
FWCI
5.23
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Otitis media. https://app.cochat.ai/papers/10.1038/nrdp.2016.63
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Schilder, A. G. M., Chonmaitree, T., Cripps, A. W., Rosenfeld, R. M., Casselbrant, M. L., Haggard, M. P., & Venekamp, R. P. (2016). Otitis media. Nature Reviews Disease Primers. https://doi.org/10.1038/nrdp.2016.63

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