The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Pemphigus
Open accessAbstract
Pemphigus is a group of IgG-mediated autoimmune diseases of stratified squamous epithelia, such as the skin and oral mucosa, in which acantholysis (the loss of cell adhesion) causes blisters and erosions. Pemphigus has three major subtypes: pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. IgG autoantibodies are characteristically raised against desmoglein 1 and desmoglein 3, which are cell–cell adhesion molecules found in desmosomes. The sites of blister formation can be physiologically explained by the anti-desmoglein autoantibody profile and tissue-specific expression pattern of desmoglein isoforms. The pathophysiological roles of T cells and B cells have been characterized in mouse models of pemphigus and patients, revealing insights into the mechanisms of autoimmunity. Diagnosis is based on clinical manifestations and confirmed with histological and immunochemical testing. The current first-line treatment is systemic corticosteroids and adjuvant therapies, including immunosuppressive agents, intravenous immunoglobulin and plasmapheresis. Rituximab, a monoclonal antibody against CD20+ B cells, is a promising therapeutic option that may soon become first-line therapy. Pemphigus is one of the best-characterized human autoimmune diseases and provides an ideal paradigm for both basic and clinical research, especially towards the development of antigen-specific immune suppression treatments for autoimmune diseases.
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(1995) · Social Science & Medicine · doi:10.1016/0277-9536(95)00112-k · Cited by 7,643
Weng, W.-K., & Levy, R. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.05.013 · Cited by 1,300
Paraneoplastic Pemphigus: An Autoimmune Mucocutaneous Disease Associated with Neoplasia
Anhalt, G. J., Kim, S., Stanley, J. R., Korman, N. J., Jabs, D. A., Kory, M., Izumi, H., Ratrie, H., Mutasim, D., Ariss-Abdo, L., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199012203232503 · Cited by 1,035
Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion
Amagai, M., Klaus-Kovtun, V., & Stanley, J. R. (1991) · Cell · doi:10.1016/0092-8674(91)90360-b · Cited by 1,021
Self-citationReengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease
Ellebrecht, C. T., Bhoj, V. G., Nace, A., Choi, E. J., Mao, X., Cho, M. J., Di Zenzo, G., Lanzavecchia, A., Seykora, J. T., Cotsarelis, G., et al. (2016) · Science · doi:10.1126/science.aaf6756 · Cited by 738
Self-citationWu, J., Edberg, J. C., Redecha, P. B., Bansal, V, Guyre, P. M., Coleman, K., Salmon, J. E., & Kimberly, R. P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119616 · Cited by 711
C-Cadherin Ectodomain Structure and Implications for Cell Adhesion Mechanisms
Boggon, T. J., Murray, J., Chappuis-Flament, S., Wong, E., Gumbiner, B. M., & Shapiro, L. (2002) · Science · doi:10.1126/science.1071559 · Cited by 669
Induction of Pemphigus in Neonatal Mice by Passive Transfer of IgG from Patients with the Disease
Anhalt, G. J., Labib, R. S., Voorhees, J. J., Beals, T. F., & Diaz, L. A. (1982) · New England Journal of Medicine · doi:10.1056/nejm198205203062001 · Cited by 663
Langan, S. M., Smeeth, L., Hubbard, R., Fleming, K. M., Smith, C. J. P., & West, J. (2008) · BMJ · doi:10.1136/bmj.a180 · Cited by 632
Joly, P., Maho-Vaillant, M., Prost-Squarcioni, C., Hebert, V., Houivet, E., Calbo, S., Caillot, F., Golinski, M. L., Labeille, B., Picard-Dahan, C., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30070-3 · Cited by 623
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The Unique Properties of IgG4 and Its Roles in Health and Disease
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Unmet medical needs in chronic, non-communicable inflammatory skin diseases
Ujiie, H., Rosmarin, D., Schön, M. P., Ständer, S., Boch, K., Metz, M., Maurer, M., Thaci, D., Schmidt, E., Cole, C., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.875492 · Cited by 158
Bioengineered Efficacy Models of Skin Disease: Advances in the Last 10 Years
Stanton, D. N., Ganguli-Indra, G., Indra, A. K., & Karande, P. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020319 · Cited by 22
Understanding CD4+ T cells in autoimmune bullous diseases
Lee, A. Y., Kim, T., & Kim, J. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1161927 · Cited by 13
Metadata
- Authors
- Kasperkiewicz, M., Ellebrecht, C. T., Takahashi, H., Yamagami, J., Zillikens, D., Payne, A. S., & Amagai, M.
- Venue
- Nature Reviews Disease Primers
- Published
- 2017-05-11
- Volume
- 3
- Issue
- 1
- Pages
- 17026-17026
- ISSN
- 2056-676X (ISSN-L)
- OpenAlex
- W4210972925
- Cited by
- 523
- References
- 107
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- green
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