The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
C-Cadherin Ectodomain Structure and Implications for Cell Adhesion Mechanisms
Abstract
Cadherins are transmembrane proteins that mediate adhesion between cells in the solid tissues of animals. Here we present the 3.1 angstrom resolution crystal structure of the whole, functional extracellular domain from C-cadherin, a representative “classical” cadherin. The structure suggests a molecular mechanism for adhesion between cells by classical cadherins, and it provides a new framework for understanding both cis (same cell) and trans (juxtaposed cell) cadherin interactions. The trans adhesive interface is a twofold symmetric interaction defined by a conserved tryptophan side chain at the membrane-distal end of a cadherin molecule from one cell, which inserts into a hydrophobic pocket at the membrane-distal end of a cadherin molecule from the opposing cell.
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Cites
PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
Gumbiner, B., Stevenson, B., & Grimaldi, A. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1575 · Cited by 799
Self-citationStructural basis of calcium-induced E-cadherin rigidification and dimerization
Nagar, B., Overduin, M., Ikura, M., & Rini, J. M. (1996) · Nature · doi:10.1038/380360a0 · Cited by 684
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Vestweber (2008) · doi:10.1161/atvbaha.107.158014 · Cited by 806
Desmosome structure, composition and function
Garrod, D., & Chidgey, M. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.014 · Cited by 580
Kasperkiewicz, M., Ellebrecht, C. T., Takahashi, H., Yamagami, J., Zillikens, D., Payne, A. S., & Amagai, M. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.26 · Cited by 523
Niessen, C. M., Leckband, D., & Yap, A. S. (2011) · Physiological Reviews · doi:10.1152/physrev.00004.2010 · Cited by 427
Qian, X., Karpova, T., Sheppard, A. M., McNally, J., & Lowy, D. R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600136 · Cited by 396
Metadata
- Authors
- Boggon, T. J., Murray, J., Chappuis-Flament, S., Wong, E., Gumbiner, B. M., & Shapiro, L.
- Venue
- Science
- Published
- 2002-05-17
- Volume
- 296
- Issue
- 5571
- Pages
- 1308-1313
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2025234475
- Cited by
- 669
- References
- 3
- FWCI
- 19.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boggon, T. J., Murray, J., Chappuis-Flament, S., Wong, E., Gumbiner, B. M., & Shapiro, L. (2002). C-Cadherin Ectodomain Structure and Implications for Cell Adhesion Mechanisms. Science. https://doi.org/10.1126/science.1071559
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