The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Causes of evolutionary rate variation among protein sites
Open accessAbstract
It has long been recognized that certain sites within a protein, such as sites in the protein core or catalytic residues in enzymes, are evolutionarily more conserved than other sites. However, our understanding of rate variation among sites remains surprisingly limited. Recent progress to address this includes the development of a wide array of reliable methods to estimate site-specific substitution rates from sequence alignments. In addition, several molecular traits have been identified that correlate with site-specific mutation rates, and novel mechanistic biophysical models have been proposed to explain the observed correlations. Nonetheless, current models explain, at best, approximately 60% of the observed variance, highlighting the limitations of current methods and models and the need for new research directions.
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Cites
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Cited by
Ashkenazy, H., Abadi, S., Martz, E., Chay, O., Mayrose, I., Pupko, T., & Ben-Tal, N. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw408 · Cited by 3,163
Perelygina, L., Chen, M.-H., Suppiah, S., Adebayo, A., Abernathy, E., Dorsey, M., Bercovitch, L., Paris, K., White, K. P., Krol, A., et al. (2019) · PLOS Pathogens · doi:10.1371/journal.ppat.1008080 · Cited by 87
Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection
Lu, H., Li, F., Yuan, L., Domenzain, I., Yu, R., Wang, H., Li, G., Chen, Y., Ji, B., Kerkhoven, E. J., et al. (2021) · Molecular Systems Biology · doi:10.15252/msb.202110427 · Cited by 44
Kiefl, E., Esen, O. C., Miller, S. E., Kroll, K. L., Willis, A. D., Rappé, M. S., Pan, T., & Eren, A. M. (2023) · Science Advances · doi:10.1126/sciadv.abq4632 · Cited by 26
Refining convergent rate analysis with topology in mammalian longevity and marine transitions
Treaster, S., Daane, J. M., & Harris, M. P. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab226 · Cited by 24
Metadata
- Authors
- Echave, J., Spielman, S. J., & Wilke, C. O.
- Venue
- Nature Reviews Genetics
- Published
- 2016-01-19
- Volume
- 17
- Issue
- 2
- Pages
- 109-121
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2266439690
- Cited by
- 328
- References
- 145
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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