Cited by 1,921Genetic and phenotypic traits in livestockGenetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

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Heritability in the genomics era — concepts and misconceptions

Visscher, Peter M., Hill, William G., Wray, Naomi R.·2008·Nature Reviews Genetics

DOI 10.1038/nrg2322

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Abstract

Heritability allows a comparison of the relative importance of genes and environment to the variation of traits within and across populations. The concept of heritability and its definition as an estimable, dimensionless population parameter was introduced by Sewall Wright and Ronald Fisher nearly a century ago. Despite continuous misunderstandings and controversies over its use and application, heritability remains key to the response to selection in evolutionary biology and agriculture, and to the prediction of disease risk in medicine. Recent reports of substantial heritability for gene expression and new estimation methods using marker data highlight the relevance of heritability in the genomics era.

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Authors: Visscher, P. M., Hill, W. G., & Wray, N. R.
Affiliations: QIMR Berghofer Medical Research Institute (AU)
University of Edinburgh (GB)
Corresponding author: Visscher, Peter M.
ORCID: Visscher, Peter M.
Hill, William G.
Wray, Naomi R.
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2008-03-04
Volume: 9
Issue: 4
Pages: 255-266
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2322
OpenAlex: W2086799994
Cited by: 1,921
References: 118
Citations by year: 2026: 75 · 2025: 112 · 2024: 88 · 2023: 117 · 2022: 135 · 2021: 132 · 2020: 140 · 2019: 126 · 2018: 119 · 2017: 113 · 2016: 112 · 2015: 109 · 2014: 126 · 2013: 120 · 2012: 110
FWCI: 5.71
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Australian Research Council
National Health and Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords: heritability, gene-environment interaction, genetic variation, heritability of gene expression, heritability estimation, selection response, disease risk prediction, Sewall Wright, Ronald Fisher
MeSH terms: Analysis of Variance, Animals, Bayes Theorem, Biological Evolution, Female, Humans, Inbreeding, Male, Models, Genetic, Phenotype, Regression Analysis, Selection, Genetic, Gene Expression, Linear Models, Quantitative Trait, Heritable, Genomics

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Heritability in the genomics era — concepts and misconceptions

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