Cited by 472Lipoproteins and Cardiovascular HealthGenetic Associations and EpidemiologyLipid metabolism and disorders

The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.

Plasma lipoproteins: genetic influences and clinical implications

Hegele, Robert A.·2009·Nature Reviews Genetics

Abstract

Susceptibility to the growing global public health problem of cardiovascular disease is associated with levels of plasma lipids and lipoproteins. Several experimental strategies have helped us to clarify the genetic architecture of these complex traits, including classical studies of monogenic dyslipidaemias, resequencing, phenomic analysis and, more recently, genome-wide association studies and analysis of metabolic networks. The genetic basis of plasma lipoprotein levels can now be modelled as a mosaic of contributions from multiple DNA sequence variants, both rare and common, with varying effect sizes. In addition to filling gaps in our understanding of plasma lipoprotein metabolism, the recent genetic advances will improve our ability to classify, diagnose and treat dyslipidaemias.

Overview

Integrity signals

Registry

Crossref · 10.1038/nrg2481

Cites

107 of 107 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 107 references

Cited by

Sorted by citations

Items 301–400 of 472

Metadata

Authors
Hegele, R. A.
Affiliations
Western University (CA)
Corresponding author
Hegele, Robert A.
Venue
Nature Reviews Genetics
Published
2009-02
Volume
10
Issue
2
Pages
109-121
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2068700927
Cited by
462
References
107
Citations by year
2026: 10 · 2025: 11 · 2024: 19 · 2023: 21 · 2022: 32 · 2021: 22 · 2020: 24 · 2019: 19 · 2018: 27 · 2017: 19 · 2016: 31 · 2015: 33 · 2014: 36 · 2013: 26 · 2012: 31
FWCI
7.03
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Scholarship@Western (Western University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
serum lipoproteins, plasma lipids, genetic architecture, cardiovascular risk, dyslipidemia, genome-wide association study, rare variants, lipid metabolism, metabolic networks, phenomics, resequencing, disease diagnosis and treatment
MeSH terms
Animals, Cholesterol, Humans, Hyperlipoproteinemias, Lipoproteins, Models, Biological, Triglycerides, Genomics, Dyslipidemias

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review