Cited by 472Lipoproteins and Cardiovascular HealthGenetic Associations and EpidemiologyLipid metabolism and disorders

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Plasma lipoproteins: genetic influences and clinical implications

Hegele, Robert A.·2009·Nature Reviews Genetics

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Abstract

Susceptibility to the growing global public health problem of cardiovascular disease is associated with levels of plasma lipids and lipoproteins. Several experimental strategies have helped us to clarify the genetic architecture of these complex traits, including classical studies of monogenic dyslipidaemias, resequencing, phenomic analysis and, more recently, genome-wide association studies and analysis of metabolic networks. The genetic basis of plasma lipoprotein levels can now be modelled as a mosaic of contributions from multiple DNA sequence variants, both rare and common, with varying effect sizes. In addition to filling gaps in our understanding of plasma lipoprotein metabolism, the recent genetic advances will improve our ability to classify, diagnose and treat dyslipidaemias.

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Authors: Hegele, R. A.
Affiliations: Western University (CA)
Corresponding author: Hegele, Robert A.
ORCID: Hegele, Robert A.
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2009-02
Volume: 10
Issue: 2
Pages: 109-121
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2481
OpenAlex: W2068700927
Cited by: 462
References: 107
Citations by year: 2026: 10 · 2025: 11 · 2024: 19 · 2023: 21 · 2022: 32 · 2021: 22 · 2020: 24 · 2019: 19 · 2018: 27 · 2017: 19 · 2016: 31 · 2015: 33 · 2014: 36 · 2013: 26 · 2012: 31
FWCI: 7.03
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Scholarship@Western (Western University) (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: serum lipoproteins, plasma lipids, genetic architecture, cardiovascular risk, dyslipidemia, genome-wide association study, rare variants, lipid metabolism, metabolic networks, phenomics, resequencing, disease diagnosis and treatment
MeSH terms: Animals, Cholesterol, Humans, Hyperlipoproteinemias, Lipoproteins, Models, Biological, Triglycerides, Genomics, Dyslipidemias

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Plasma lipoproteins: genetic influences and clinical implications

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