The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Missing heritability and strategies for finding the underlying causes of complex disease
Open accessAbstract
Although recent genome-wide studies have provided valuable insights into the genetic basis of human disease, they have explained relatively little of the heritability of most complex traits, and the variants identified through these studies have small effect sizes. This has led to the important and hotly debated issue of where the 'missing heritability' of complex diseases might be found. Here, seven leading geneticists offer their opinion about where this heritability is likely to lie, what this could tell us about the underlying genetic architecture of common diseases and how this could inform research strategies for uncovering genetic risk factors.
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Cites
Finding the missing heritability of complex diseases
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Self-citationCommon polygenic variation contributes to risk of schizophrenia and bipolar disorder
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Visscher, P. M., Hill, W. G., & Wray, N. R. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2322 · Cited by 1,921 · cited 1×
“A lot of the confusion may arise because heritability seems often to be equated with genetic contributions, but it actually refers to the ratio of the genetic to the total phenotypic variance in a populatio”
BackgroundDetecting gene–gene interactions that underlie human diseases
Cordell, H. J. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2579 · Cited by 1,350
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Self-citationA Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic
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Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol
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Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits
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Cited by
GCTA: a tool for genome-wide complex trait analysis
Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279
Meta-analysis of the heritability of human traits based on fifty years of twin studies
Polderman, T. J. C., Benyamin, B., de Leeuw, C. A., Sullivan, P. F., van Bochoven, A., Visscher, P. M., & Posthuma, D. (2015) · Nature Genetics · doi:10.1038/ng.3285 · Cited by 2,467
The mystery of missing heritability: Genetic interactions create phantom heritability
Zuk, O., Hechter, E., Sunyaev, S. R., & Lander, E. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119675109 · Cited by 1,542
Rare and common variants: twenty arguments
Gibson, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3118 · Cited by 1,278
Self-citationGenetic architectures of psychiatric disorders: the emerging picture and its implications
Sullivan, P. F., Daly, M. J., & O'Donovan, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3240 · Cited by 1,177
Metadata
- Authors
- Eichler, E. E., Flint, J., Gibson, G., Kong, A., Leal, S. M., Moore, J. H., & Nadeau, J. H.
- Venue
- Nature Reviews Genetics
- Published
- 2010-06
- Volume
- 11
- Issue
- 6
- Pages
- 446-450
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2167638767
- Cited by
- 1,687
- References
- 18
- FWCI
- 13.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Eichler, E. E., Flint, J., Gibson, G., Kong, A., Leal, S. M., Moore, J. H., & Nadeau, J. H. (2010). Missing heritability and strategies for finding the underlying causes of complex disease. Nature Reviews Genetics. https://doi.org/10.1038/nrg2809
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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