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Cited by 410

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Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity

Open access
Matson, Clinton K., Zarkower, David·2012·Nature Reviews Genetics
DOI 10.1038/nrg3161
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Abstract

Most animals reproduce sexually, but the genetic and molecular mechanisms that determine the eventual sex of each embryo vary remarkably. DM domain genes, which are related to the insect gene doublesex, are integral to sexual development and its evolution in many metazoans. Recent studies of DM domain genes reveal mechanisms by which new sexual dimorphisms have evolved in invertebrates and show that one gene, Dmrt1, was central to multiple evolutionary transitions between sex-determining mechanisms in vertebrates. In addition, Dmrt1 coordinates a surprising array of distinct cell fate decisions in the mammalian gonad and even guards against transdifferentiation of male cells into female cells in the adult testis.

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Metadata

Authors
Matson, C. K., & Zarkower, D.
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2012-02-07
Volume
13
Issue
3
Pages
163-174
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
DOI
10.1038/nrg3161
OpenAlex
W1979997225
Cited by
410
References
0
FWCI
4.14
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity. https://app.cochat.ai/papers/10.1038/nrg3161
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Matson, C. K., & Zarkower, D. (2012). Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity. Nature Reviews Genetics. https://doi.org/10.1038/nrg3161

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.