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Comparative studies of gene expression and the evolution of gene regulation
Open accessAbstract
The hypothesis that differences in gene regulation have an important role in speciation and adaptation is more than 40 years old. With the advent of new sequencing technologies, we are able to characterize and study gene expression levels and associated regulatory mechanisms in a large number of individuals and species at an unprecedented resolution and scale. We have thus gained new insights into the evolutionary pressures that shape gene expression levels and have developed an appreciation for the relative importance of evolutionary changes in different regulatory genetic and epigenetic mechanisms. The current challenge is to link gene regulatory changes to adaptive evolution of complex phenotypes. Here we mainly focus on comparative studies in primates and how they are complemented by studies in model organisms.
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Metadata
- Authors
- Romero, I. G., Ruvinsky, I., & Gilad, Y.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Gilad, Yoav
- Venue
- Nature Reviews Genetics
- Published
- 2012-06-18
- Volume
- 13
- Issue
- 7
- Pages
- 505-516
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC4034676
- OpenAlex
- W2001157929
- Cited by
- 488
- References
- 119
- Citations by year
- 2026: 28 · 2025: 38 · 2024: 37 · 2023: 32 · 2022: 51 · 2021: 27 · 2020: 46 · 2019: 36 · 2018: 41 · 2017: 30 · 2016: 24 · 2015: 36 · 2014: 32 · 2013: 25 · 2012: 4
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust
- National Institute of General Medical Sciences (R01GM084996, GM077959, P50GM081892, R01GM077959, GM084996)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- gene expression evolution, gene expression regulation, gene expression comparison, primates, speciation, adaptation, epigenetic regulation, model organisms
- MeSH terms
- Adaptation, Biological, Animals, Biological Evolution, Gene Expression Regulation, Models, Genetic, Physiology, Comparative, Primates, Selection, Genetic, Species Specificity, Transcription Factors, Epigenesis, Genetic, Genetic Speciation
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