Evolution at Two Levels in Humans and Chimpanzees: Their macromolecules are so alike that regulatory mutations may account for their biological differences
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Gene expression change has been considered a major driver of species differentiation and evolution.
“Gene expression change has been considered a major driver of species differentiation and evolution (King and Wilson, 1975).”
From Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures (2012) · cites this paper as King and Wilson, 1975
Changes in gene expression are likely to have important adaptive effects in humans.
“supporting the idea that changes in gene expression are likely to have important adaptive effects in humans [42].”
From Functional implications of Neandertal introgression in modern humans (2017) · cites this paper as [42]
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Signatures of Recent Positive Selection in Enhancers Across 41 Human Tissues
Moon, J. M., Capra, J. A., Abbot, P., & Rokas, A. (2019) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.119.400186 · Cited by 24 · see citing works
Guild-based approach for mitigating information loss and distortion issues in microbiome analysis
Zhao, L., Wu, G., & Zhao, N. (2024) · Journal of Clinical Investigation · doi:10.1172/jci185395 · Cited by 9 · see citing works
- Authors
- King, M.-C., & Wilson, A. C.
- Affiliations
- University of California, Berkeley (US)
- Venue
- Science
- Published
- 1975-04-11
- Volume
- 188
- Issue
- 4184
- Pages
- 107-116
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2128969076
- Cited by
- 2,815
- References
- 136
- Citations by year
- 2026: 60 · 2025: 81 · 2024: 92 · 2023: 83 · 2022: 72 · 2021: 76 · 2020: 95 · 2019: 73 · 2018: 71 · 2017: 81 · 2016: 91 · 2015: 103 · 2014: 106 · 2013: 108 · 2012: 100
- FWCI
- 462.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Cultural Studies › Language and cultural evolution
- Keywords
- human evolution, comparative evolution, human-chimpanzee divergence, primate evolution
- MeSH terms
- Alleles, Amino Acid Sequence, Animals, Pan troglodytes, Electrophoresis, Enzymes, Biological Evolution, Genes, Genetic Code, Humans, Models, Biological, Mutation, Proteins, Protein Biosynthesis
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