The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Notch signalling system: recent insights into the complexity of a conserved pathway
Open accessAbstract
Notch signalling links the fate of one cell to that of an immediate neighbour and consequently controls differentiation, proliferation and apoptotic events in multiple metazoan tissues. Perturbations in this pathway activity have been linked to several human genetic disorders and cancers. Recent genome-scale studies in Drosophila melanogaster have revealed an extraordinarily complex network of genes that can affect Notch activity. This highly interconnected network contrasts our traditional view of the Notch pathway as a simple linear sequence of events. Although we now have an unprecedented insight into the way in which such a fundamental signalling mechanism is controlled by the genome, we are faced with serious challenges in analysing the underlying molecular mechanisms of Notch signal control.
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Cited by
Liao, J., Wei, Q., Zou, Y., Fan, J., Song, D., Cui, J., Zhang, W., Zhu, Y., Ma, C., Hu, X., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471945 · Cited by 2,742
YAP/TAZ upstream signals and downstream responses
Totaro, A., Panciera, T., & Piccolo, S. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0142-z · Cited by 1,086
Mechanisms Governing Metastatic Dormancy and Reactivation
Giancotti, F. G. (2013) · Cell · doi:10.1016/j.cell.2013.10.029 · Cited by 586
Signaling through the Primary Cilium
Wheway, G., Nazlamova, L., & Hancock, J. T. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00008 · Cited by 483
Dynamic Ligand Discrimination in the Notch Signaling Pathway
Nandagopal, N., Santat, L. A., LeBon, L., Sprinzak, D., Bronner, M. E., & Elowitz, M. B. (2018) · Cell · doi:10.1016/j.cell.2018.01.002 · Cited by 322
Metadata
- Authors
- Guruharsha, K. G., Kankel, M. W., & Artavanis-Tsakonas, S.
- Venue
- Nature Reviews Genetics
- Published
- 2012-08-07
- Volume
- 13
- Issue
- 9
- Pages
- 654-666
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W1971571526
- Cited by
- 705
- References
- 9
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Guruharsha, K. G., Kankel, M. W., & Artavanis-Tsakonas, S. (2012). The Notch signalling system: recent insights into the complexity of a conserved pathway. Nature Reviews Genetics. https://doi.org/10.1038/nrg3272
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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