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Cited by 483Genetic and Kidney Cyst DiseasesCystic Fibrosis Research AdvancesHedgehog Signaling Pathway Studies

Signaling through the Primary Cilium

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Wheway, Gabrielle, Nazlamova, Liliya, Hancock, John T.·2018·Frontiers in Cell and Developmental Biology
DOI 10.3389/fcell.2018.00008PMC PMC5809511
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Abstract

The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It wasn't until 2003, with the discovery that proteins responsible for transport along the primary cilium are essential for hedgehog signaling in mice, that the fundamental importance of primary cilia in signal transduction was realized. Little more than a decade later, it is now clear that the vast majority of signaling pathways in vertebrates function through the primary cilium. This has led to the adoption of the term "the cells's antenna" as a description for the primary cilium. Primary cilia are particularly important during development, playing fundamental roles in embryonic patterning and organogenesis, with a suite of inherited developmental disorders known as the "ciliopathies" resulting from mutations in genes encoding cilia proteins. This review summarizes our current understanding of the role of these fascinating organelles in a wide range of signaling pathways.

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  • The primary cilium enables extracellular signalling through a variety of ion channels and signalling receptors.

    “The axoneme of the primary cilium protrudes from the cell surface, which enables extracellular signalling through a variety of ion channels and signalling receptors (Wheway et al. 2018; Anvarian et al. 2019).”

    From Astrocyte-specific inhibition of the primary cilium suppresses C3 expression in reactive astrocyte (2024) · cites this paper as Wheway et al. 2018

    In “An introduction to the primary cilium” (page unavailable), the paper says the cilium protrudes from the cell surface and that receptors in its membrane let cells respond to external stimuli. It describes diverse signaling pathways, but the passages found do not identify ion channels as a means of that signaling. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Wheway, G., Nazlamova, L., & Hancock, J. T.
Affiliations
University of the West of England (GB)
Corresponding author
Hancock, John T.
ORCID
Venue
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media SA
Published
2018-02-08
Volume
6
Pages
8-8
ISSN
2296-634X (ISSN-L)
DOI
10.3389/fcell.2018.00008
PMC
PMC5809511
OpenAlex
W2785279167
Cited by
483
References
11
Citations by year
2026: 24 · 2025: 50 · 2024: 66 · 2023: 71 · 2022: 75 · 2021: 79 · 2020: 51 · 2019: 50 · 2018: 14 · 2017: 1
FWCI
6.70
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • UWE Research Repository (UWE Bristol) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Wellcome Trust (Seed Award in Science)
  • National Eye Research Centre (SAC019)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords
primary cilia, ciliary signaling, signal transduction, Hedgehog signaling, ciliopathies, embryonic patterning, organogenesis, epithelial cells

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