YAP/TAZ upstream signals and downstream responses

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works

Role of YAP/TAZ in mechanotransduction

Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works

Local force and geometry sensing regulate cell functions

Vogel, V., & Sheetz, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1890 · Cited by 2,328 · see citing works

Mechanotransduction and extracellular matrix homeostasis

Humphrey, J. D., Dufresne, E. R., & Schwartz, M. A. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3896 · Cited by 2,187 · see citing works

YAP/TAZ at the Roots of Cancer

Zanconato, F., Cordenonsi, M., & Piccolo, S. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.005 · Cited by 1,970 · see citing works

The Biology of YAP/TAZ: Hippo Signaling and Beyond

Piccolo, S., Dupont, S., & Cordenonsi, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00005.2014 · Cited by 1,797 · see citing works

Mechanisms of Hippo pathway regulation

Meng, Z., Moroishi, T., & Guan, K.-L. (2016) · Genes & Development · doi:10.1101/gad.274027.115 · Cited by 1,667 · see citing works

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

Aragona, M., Panciera, T., Manfrin, A., Giulitti, S., Michielin, F., Elvassore, N., Dupont, S., & Piccolo, S. (2013) · Cell · doi:10.1016/j.cell.2013.07.042 · Cited by 1,651 · see citing works

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.037 · Cited by 1,628 · see citing works

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

Bissell, M. J., & Hines, W. C. (2011) · Nature Medicine · doi:10.1038/nm.2328 · Cited by 1,516 · see citing works

Force triggers YAP nuclear entry by regulating transport across nuclear pores

Elosegui-Artola, A., Andreu, I., Beedle, A. E. M., Lezamiz, A., Uroz, M., Kosmalska, A. J., Oria, R., Kechagia, J. Z., Rico-Lastres, P., Le Roux, A.-L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.008 · Cited by 1,491 · see citing works

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478 · see citing works

Mechanobiology of YAP and TAZ in physiology and disease

Panciera, T., Azzolin, L., Cordenonsi, M., & Piccolo, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.87 · Cited by 1,461 · see citing works

Designer matrices for intestinal stem cell and organoid culture

Gjorevski, N., Sachs, N., Manfrin, A., Giger, S., Bragina, M. E., Ordóñez-Morán, P., Clevers, H., & Lutolf, M. P. (2016) · Nature · doi:10.1038/nature20168 · Cited by 1,426 · see citing works

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

Cordenonsi, M., Zanconato, F., Azzolin, L., Forcato, M., Rosato, A., Frasson, C., Inui, M., Montagner, M., Parenti, A. R., Poletti, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.048 · Cited by 1,381 · see citing works

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

Zanconato, F., Forcato, M., Battilana, G., Azzolin, L., Quaranta, E., Bodega, B., Rosato, A., Bicciato, S., Cordenonsi, M., & Piccolo, S. (2015) · Nature Cell Biology · doi:10.1038/ncb3216 · Cited by 1,219 · see citing works

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

Shaffer, S. M., Dunagin, M. C., Torborg, S. R., Torre, E. A., Emert, B., Krepler, C., Beqiri, M., Sproesser, K., Brafford, P. A., Xiao, M., et al. (2017) · Nature · doi:10.1038/nature22794 · Cited by 1,218 · see citing works

Transcriptional Addiction in Cancer

Bradner, J. E., Hnisz, D., & Young, R. A. (2017) · Cell · doi:10.1016/j.cell.2016.12.013 · Cited by 1,188 · see citing works

hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts

Wu, S., Huang, J., Dong, J., & Pan, D. (2003) · Cell · doi:10.1016/s0092-8674(03)00549-x · Cited by 1,101 · see citing works

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

Azzolin, L., Panciera, T., Soligo, S., Enzo, E., Bicciato, S., Dupont, S., Bresolin, S., Frasson, C., Basso, G., Guzzardo, V., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.013 · Cited by 1,094 · see citing works

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

Heallen, T. R., Zhang, M., Wang, J., Bonilla-Claudio, M., Klysik, E., Johnson, R. L., & Martin, J. F. (2011) · Science · doi:10.1126/science.1199010 · Cited by 1,092 · see citing works

Yap1 acts downstream of α-catenin to control epidermal proliferation

Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.031 · Cited by 1,036 · see citing works

TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation

Hong, J.-H., Hwang, E. S., McManus, M. T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B. M., Sharp, P. A., et al. (2005) · Science · doi:10.1126/science.1110955 · Cited by 1,009 · see citing works

Balancing forces: architectural control of mechanotransduction

DuFort, C. C., Paszek, M. J., & Weaver, V. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3112 · Cited by 987 · see citing works

The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis

Harvey, K. F., Pfleger, C. M., & Hariharan, I. K. (2003) · Cell · doi:10.1016/s0092-8674(03)00557-9 · Cited by 983 · see citing works

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.

Justice, R. W., Zilian, O., Woods, D. F., Noll, M., & Bryant, P. J. (1995) · Genes & Development · doi:10.1101/gad.9.5.534 · Cited by 977 · see citing works

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

Johnson, R. L., & Halder, G. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4161 · Cited by 884 · see citing works

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

Plotnikov, S. V., Pasapera, A. M., Sabass, B., & Waterman, C. M. (2012) · Cell · doi:10.1016/j.cell.2012.11.034 · Cited by 866 · see citing works

salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines

Tapon, N., Harvey, K. F., Bell, D. W., Wahrer, D. C. R., Schiripo, T. A., Haber, D. A., & Hariharan, I. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00824-3 · Cited by 858 · see citing works

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

Elosegui-Artola, A., Oria, R., Chen, Y., Kosmalska, A., Pérez-González, C., Castro, N., Zhu, C., Trepat, X., & Roca-Cusachs, P. (2016) · Nature Cell Biology · doi:10.1038/ncb3336 · Cited by 858 · see citing works

Hippo pathway regulation by cell morphology and stress fibers

Wada, K., Itoga, K., Okano, T., Yonemura, S., & Sasaki, H. (2011) · Development · doi:10.1242/dev.070987 · Cited by 852 · see citing works

Identifying tumor suppressors in genetic mosaics: the <i>Drosophila lats</i> gene encodes a putative protein kinase

Xu, T., Wang, W., Zhang, S., Stewart, R. A., & Yu, W. (1995) · Development · doi:10.1242/dev.121.4.1053 · Cited by 799 · see citing works

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikisPreprint

Zhao, B., Li, L., Wang, L., Wang, C.-Y., Yu, J., & Guan, K. (2012) · Genes & Development · doi:10.1101/gad.173435.111 · Cited by 794 · see citing works

The structural and mechanical complexity of cell-growth control

Huang, S., & Ingber, D. E. (1999) · Nature Cell Biology · doi:10.1038/13043 · Cited by 785 · see citing works

Metabolic control of YAP and TAZ by the mevalonate pathway

Sorrentino, G., Ruggeri, N., Specchia, V., Cordenonsi, M., Mano, M., Dupont, S., Manfrin, A., Ingallina, E., Sommaggio, R., Piazza, S., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2936 · Cited by 776 · see citing works

Reparative inflammation takes charge of tissue regeneration

Karin, M., & Clevers, H. (2016) · Nature · doi:10.1038/nature17039 · Cited by 767 · see citing works

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., Schafer, E. J., Zack, T. I., Wang, X., Tsherniak, A., Schinzel, A. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.11.026 · Cited by 757 · see citing works

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

Kapoor, A., Yao, W., Ying, H., Hua, S., Liewen, A., Wang, Q., Zhong, Y., Wu, C.-J., Sadanandam, A., Hu, B., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.003 · Cited by 716 · see citing works

Alternative Wnt Signaling Activates YAP/TAZ

Park, H. W., Kim, Y. C., Yu, B., Moroishi, T., Mo, J., Plouffe, S. W., Meng, Z., Lin, K. C., Yu, F., Alexander, C. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.013 · Cited by 708 · see citing works

The Notch signalling system: recent insights into the complexity of a conserved pathway

Guruharsha, K. G., Kankel, M. W., & Artavanis‐Tsakonas, S. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3272 · Cited by 700 · see citing works

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

Varelas, X., Samavarchi‐Tehrani, P., Narimatsu, M., Weiss, A., Cockburn, K., Larsen, B. G., Rossant, J., & Wrana, J. L. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.11.012 · Cited by 683 · see citing works

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

Yui, S., Azzolin, L., Maimets, M., Pedersen, M. T., Fordham, R. P., Hansen, S. L., Larsen, H. L., Guiu, J., Alves, M. R. P., Rundsten, C. F., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.11.001 · Cited by 678 · see citing works

YAP regulates cell mechanics by controlling focal adhesion assembly

Nardone, G., Cruz, J. O. L., Vrbský, J., Martini, C., Přibyl, J., Skládal, P., Pešl, M., Caluori, G., Pagliari, S., Martino, F. D., et al. (2017) · Nature Communications · doi:10.1038/ncomms15321 · Cited by 669 · see citing works

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

Wang, L., Luo, J., Li, B., Tian, X. Y., Chen, L., Huang, Y., Liu, J., Deng, D., Lau, C. W., Wan, S., et al. (2016) · Nature · doi:10.1038/nature20602 · Cited by 666 · see citing works

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoproteinPreprint

Zhao, B., Li, L., Lu, Q. R., Wang, L. H., Liu, C., Lei, Q., & Guan, K. (2011) · Genes & Development · doi:10.1101/gad.2000111 · Cited by 665 · see citing works

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

Pathak, M. M., Nourse, J. L., Tran, T., Hwe, J., Arulmoli, J., Le, D. T. T., Bernardis, E., Flanagan, L. A., & Tombola, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409802111 · Cited by 657 · see citing works

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

Gregorieff, A., Liu, Y., Inanlou, M. R., Khomchuk, Y., & Wrana, J. L. (2015) · Nature · doi:10.1038/nature15382 · Cited by 647 · see citing works

The extracellular matrix protein agrin promotes heart regeneration in mice

Bassat, E., Mutlak, Y. E., Genzelinakh, A., Shadrin, I. Y., Umansky, K. B., Yifa, O., Kain, D., Rajchman, D., Leach, J. P., Riabov-Bassat, D., et al. (2017) · Nature · doi:10.1038/nature22978 · Cited by 637 · see citing works

A gp130–Src–YAP module links inflammation to epithelial regeneration

Taniguchi, K., Wu, L.-W., Grivennikov, S. I., de Jong, P. R., Lian, I., Yu, F.-X., Wang, K., Ho, S. B., Boland, B. S., Chang, J. T., et al. (2015) · Nature · doi:10.1038/nature14228 · Cited by 633 · see citing works

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

Jiao, S., Wang, H., Shi, Z., Dong, A., Zhang, W., Song, X., He, F., Wang, Y., Zhang, Z., Wang, W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.01.010 · Cited by 605 · see citing works

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

Varelas, X., Miller, B. W., Sopko, R., Song, S., Gregorieff, A., Fellouse, F. A., Sakuma, R., Pawson, T. J., Hunziker, W., McNeill, H., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.007 · Cited by 571 · see citing works

Emerging views of the nucleus as a cellular mechanosensor

Kirby, T. J., & Lammerding, J. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0038-y · Cited by 560 · see citing works

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

Feng, X., Degese, M. S., Iglesias‐Bartolomé, R., Vaque, J. P., Molinolo, A., Rodrigues, M. W., Zaidi, M. R., Ksander, B. R., Merlino, G. T., Sodhi, A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.016 · Cited by 559 · see citing works

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

Mo, J.-S., Meng, Z., Kim, Y. C., Park, H. W., Hansen, C. G., Kim, S., Lim, D.-S., & Guan, K.-L. (2015) · Nature Cell Biology · doi:10.1038/ncb3111 · Cited by 557 · see citing works

AMPK modulates Hippo pathway activity to regulate energy homeostasis

Wang, W., Xiao, Z.-D., Li, X., Aziz, K. E., Gan, B., Johnson, R. L., & Chen, J. (2015) · Nature Cell Biology · doi:10.1038/ncb3113 · Cited by 549 · see citing works

Mechanical strain induces E-cadherin–dependent Yap1 and β-catenin activation to drive cell cycle entry

Benham-Pyle, B. W., Pruitt, B. L., & Nelson, W. J. (2015) · Science · doi:10.1126/science.aaa4559 · Cited by 539 · see citing works

Restriction of intestinal stem cell expansion and the regenerative response by YAP

Barry, E., Morikawa, T., Butler, B. L., Shrestha, K., de la Rosa, R., Yan, K. S., Fuchs, C. S., Magness, S. T., Smits, R., Ogino, S., et al. (2012) · Nature · doi:10.1038/nature11693 · Cited by 537 · see citing works

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Meng, Z., Moroishi, T., Mottier, V., Plouffe, S. W., Hansen, C. G., Hong, A. W., Park, H. W., Mo, J., Lü, W., Lu, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9357 · Cited by 524 · see citing works

Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

Xin, M., Olson, E. N., & Bassel-Duby, R. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3619 · Cited by 514 · see citing works

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

Yin, F., Yu, J., Zheng, Y., Chen, Q., Zhang, N., & Pan, D. (2013) · Cell · doi:10.1016/j.cell.2013.08.025 · Cited by 506 · see citing works

Role of TAZ as Mediator of Wnt Signaling

Azzolin, L., Zanconato, F., Bresolin, S., Forcato, M., Basso, G., Bicciato, S., Cordenonsi, M., & Piccolo, S. (2012) · Cell · doi:10.1016/j.cell.2012.11.027 · Cited by 490 · see citing works

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

Yu, F., Luo, J., Mo, J., Liu, G., Kim, Y. C., Meng, Z., Zhao, L., Peyman, G. A., Ouyang, H. W., Jiang, W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.017 · Cited by 464 · see citing works

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

Tumaneng, K., Schlegelmilch, K., Russell, R. C., Yimlamai, D., Basnet, H., Mahadevan, N., Fitamant, J., Bardeesy, N., Camargo, F. D., & Guan, K.-L. (2012) · Nature Cell Biology · doi:10.1038/ncb2615 · Cited by 453 · see citing works

Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of <i>Yap65</i>

Morin-Kensicki, E. M., Boone, B. N., Howell, M., Stonebraker, J. R., Teed, J., Alb, J. G., Magnuson, T. R., O'Neal, W., & Milgram, S. L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.77-87.2006 · Cited by 429 · see citing works

Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets<i>Cyr61</i>and<i>CTGF</i>

Lai, D., Ho, K. C., Hao, Y., & Yang, X. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2711 · Cited by 416 · see citing works

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

Stein, C., Bardet, A. F., Roma, G., Bergling, S., Clay, I., Ruchti, A., Agarinis, C., Schmelzle, T., Bouwmeester, T., Schübeler, D., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005465 · Cited by 414 · see citing works

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

Enzo, E., Santinon, G., Pocaterra, A., Aragona, M., Bresolin, S., Forcato, M., Grifoni, D., Pession, A., Zanconato, F., Guzzo, G., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490379 · Cited by 414 · see citing works

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

Kim, J., Kim, Y. H., Kim, J., Park, D. Y., Bae, H., Lee, D. H., Kim, K. H., Hong, S. P., Jang, S. P., Kubota, Y., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93825 · Cited by 402 · see citing works

Emerging cytokine networks in colorectal cancer

West, N. R., McCuaig, S., Franchini, F., & Powrie, F. M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3896 · Cited by 401 · see citing works

YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis

Wang, X., Valls, A. F., Schermann, G., Shen, Y., Moya, I. M., Castro, L., Urban, S., Solecki, G. M., Winkler, F., Riedemann, L., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.08.002 · Cited by 370 · see citing works

Signalling dynamics in vertebrate segmentation

Hubaud, A., & Pourquié, O. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3891 · Cited by 365 · see citing works

The Transcriptional Coactivator Yes-Associated Protein Drives p73 Gene-Target Specificity in Response to DNA Damage

Strano, S., Monti, O., Pediconi, N., Baccarini, A., Fontemaggi, G., Lapi, E., Mantovani, F., Damalas, A., Citro, G., Sacchi, A., et al. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.04.008 · Cited by 360 · see citing works

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

Levy, D., Adamovich, Y., Reuven, N. B., & Shaul, Y. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.022 · Cited by 348 · see citing works

α-Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

Silvis, M. R., Kreger, B. T., Lien, W., Klezovitch, O., Rudakova, G. M., Camargo, F. D., Lantz, D. M., Seykora, J. T., & Vasioukhin, V. I. (2011) · Science Signaling · doi:10.1126/scisignal.2001823 · Cited by 342 · see citing works

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiationPreprint

Yu, F., Zhang, Y., Park, H. W., Jewell, J. L., Chen, Q., Deng, Y., Pan, D., Taylor, S. S., Lai, Z.-C., & Guan, K. (2013) · Genes & Development · doi:10.1101/gad.219402.113 · Cited by 337 · see citing works

NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctionsPreprint

Lallemand, D., Curto, M., Saotome, I., Giovannini, M., & McClatchey, A. I. (2003) · Genes & Development · doi:10.1101/gad.1054603 · Cited by 324 · see citing works

Mechanotransduction in tumor progression: The dark side of the force

Broders-Bondon, F., Nguyen Ho-Bouldoires, T. H., Fernandez-Sanchez, M.-E., & Farge, E. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201701039 · Cited by 319 · see citing works

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

Wang, Z., Wu, Y., Wang, H., Zhang, Y., Mei, L., Fang, X., Zhang, X., Zhang, F., Chen, H., Liu, Y., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319190110 · Cited by 315 · see citing works

Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance

Nakajima, H., Yamamoto, K., Agarwala, S., Terai, K., Fukui, H., Fukuhara, S., Ando, K., Miyazaki, T., Yokota, Y., Schmelzer, E., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.02.019 · Cited by 308 · see citing works

Integrin signalling regulates YAP/TAZ to control skin homeostasis

Elbediwy, A., Vincent‐Mistiaen, Z. I., Spencer‐Dene, B., Stone, R. K., Boeing, S., Wculek, S. K., Cordero, J., Tan, E. H., Ridgway, R., Brunton, V. G., et al. (2016) · Development · doi:10.1242/dev.133728 · Cited by 307 · see citing works

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

Lehmann, W., Mossmann, D., Kleemann, J., Mock, K., Meisinger, C., Brummer, T., Herr, R., Brabletz, S., Stemmler, M. P., & Brabletz, T. (2016) · Nature Communications · doi:10.1038/ncomms10498 · Cited by 305 · see citing works

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

Zhang, W., Gao, Y., Li, P., Shi, Z., Guo, T., Li, F., Han, X., Feng, Y., Zheng, C., Wang, Z., et al. (2014) · Cell Research · doi:10.1038/cr.2014.10 · Cited by 300 · see citing works

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

Reginensi, A., Scott, R. P., Gregorieff, A., Bagherie-Lachidan, M., Chung, C., Lim, D., Pawson, T. J., Wrana, J. L., & McNeill, H. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003380 · Cited by 295 · see citing works

Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ

Makita, R., Uchijima, Y., Nishiyama, K., Amano, T., Chen, Q., Takeuchi, T., Mitani, A., Nagase, T., Yatomi, Y., Aburatani, H., et al. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00201.2007 · Cited by 294 · see citing works

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

Totaro, A., Castellan, M., Battilana, G., Zanconato, F., Azzolin, L., Giulitti, S., Cordenonsi, M., & Piccolo, S. (2017) · Nature Communications · doi:10.1038/ncomms15206 · Cited by 294 · see citing works

Switch Enhancers Interpret TGF-β and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells

Beyer, T. A., Weiss, A., Khomchuk, Y., Huang, K., Ogunjimi, A. A., Varelas, X., & Wrana, J. L. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.021 · Cited by 293 · see citing works

YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers

Galli, G. G., Carrara, M., Yuan, W.-C., Valdes-Quezada, C., Gurung, B., Pepe-Mooney, B., Zhang, T., Geeven, G., Gray, N. S., de Laat, W., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.09.001 · Cited by 290 · see citing works

Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ

Kim, M., Kim, T., Johnson, R. L., & Lim, D. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.015 · Cited by 285 · see citing works

Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury

Tao, G., Kahr, P. C., Morikawa, Y., Zhang, M., Rahmani, M., Heallen, T. R., Li, L., Sun, Z. Q., Olson, E. N., Amendt, B. A., et al. (2016) · Nature · doi:10.1038/nature17959 · Cited by 283 · see citing works

YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes

Mizuno, T., Murakami, H., Fujii, M., Ishiguro, F., Tanaka, I., Kondo, Y., Akatsuka, S., Toyokuni, S., Yokoi, K., Osada, H., et al. (2012) · Oncogene · doi:10.1038/onc.2012.5 · Cited by 279 · see citing works

Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation

Peng, C., Zhu, Y., Zhang, W., Liao, Q., Chen, Y., Zhao, X., Guo, Q., Shen, P., Zhen, B., Qian, X., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.10.010 · Cited by 279 · see citing works

A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response

Shao, D., Zhai, P., Re, D. P. D., Sciarretta, S., Yabuta, N., Nojima, H., Lim, D., Pan, D., & Sadoshima, J. (2014) · Nature Communications · doi:10.1038/ncomms4315 · Cited by 276 · see citing works

The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway

Furth, N., & Aylon, Y. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.99 · Cited by 262 · see citing works

YAP is essential for tissue tension to ensure vertebrate 3D body shape

Porazinski, S. R., Wang, H., Asaoka, Y., Behrndt, M., Miyamoto, T., Morita, H., Hata, S., Sasaki, T., Krens, G., Osada, Y., et al. (2015) · Nature · doi:10.1038/nature14215 · Cited by 260 · see citing works

MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis

Tang, Y., Rowe, R. G., Botvinick, E. L., Kurup, A., Putnam, A. J., Seiki, M., Weaver, V. M., Keller, E. T., Goldstein, S. A., Dai, J., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.04.011 · Cited by 253 · see citing works

Correction: Corrigendum: Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

Evrard, S., Lecce, L., Michelis, K. C., Nomura-Kitabayashi, A., Pandey, G. S., Purushothaman, K., d’Escamard, V., Li, J. R., Hadri, L., Fujitani, K., et al. (2017) · Nature Communications · doi:10.1038/ncomms14710 · Cited by 250 · see citing works

YAP Nuclear Localization in the Absence of Cell-Cell Contact Is Mediated by a Filamentous Actin-dependent, Myosin II- and Phospho-YAP-independent Pathway during Extracellular Matrix Mechanosensing

Das, A., Fischer, R. S., Pan, D., & Waterman, C. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.708313 · Cited by 246 · see citing works

An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice

Hu, J. K., Du, W. T., Shelton, S. J., Oldham, M. C., DiPersio, C. M., & Klein, O. D. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.03.023 · Cited by 241 · see citing works

The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

Zhang, X., Qiao, Y., Wu, Q., Chen, Y., Zou, S., Liu, X., Zhu, G., Zhao, Y., Chen, Y., Yu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms15280 · Cited by 234 · see citing works

Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling

Codelia, V. A., Sun, G., & Irvine, K. D. (2014) · Current Biology · doi:10.1016/j.cub.2014.07.034 · Cited by 233 · see citing works

Tead and AP1 Coordinate Transcription and Motility

Liu, X., Li, H., Rajurkar, M., Li, Q., Cotton, J. L., Ou, J., Zhu, L. J., Goel, H. L., Mercurio, A. M., Park, J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.104 · Cited by 231 · see citing works

Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst

Rayón, T., Menchero, S., Nieto, A., Xenopoulos, P., Crespo, M., Cockburn, K., Cañón, S., Sasaki, H., Hadjantonakis, A., de la Pompa, J. L., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.06.019 · Cited by 231 · see citing works

Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ

Panciera, T., Azzolin, L., Fujimura, A., di Biagio, D., Frasson, C., Bresolin, S., Soligo, S. M., Basso, G., Bicciato, S., Rosato, A., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.08.009 · Cited by 228 · see citing works

Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells

Du, X., Wen, J., Wang, Y., Karmaus, P. W. F., Khatamian, A., Tan, H., Li, Y., Guy, C. S., Nguyen, T.-L. M., Dhungana, Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0177-0 · Cited by 224 · see citing works

Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice

Morikawa, Y., Zhang, M., Heallen, T. R., Leach, J. P., Tao, G., Xiao, Y., Bai, Y., Li, W., Willerson, J. T., & Martin, J. F. (2015) · Science Signaling · doi:10.1126/scisignal.2005781 · Cited by 221 · see citing works

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesisPreprint

Chen, Q., Zhang, N., Gray, R. S., Li, H., Ewald, A. J., Zahnow, C. A., & Pan, D. (2014) · Genes & Development · doi:10.1101/gad.233676.113 · Cited by 220 · see citing works

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

Martin, K., Pritchett, J. P., Llewellyn, J., Mullan, A. F., Athwal, V. S., Dobie, R., Harvey, E., Zeef, L. A. H., Farrow, S. N., Streuli, C. H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12502 · Cited by 220 · see citing works

The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells

Geng, J., Yu, S., Zhao, H., Sun, X., Li, X., Wang, P., Xiong, X., Hong, L., Xie, C., Gao, J., et al. (2017) · Nature Immunology · doi:10.1038/ni.3748 · Cited by 220 · see citing works

Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation

Caliari, S. R., Perepelyuk, M., Cosgrove, B. D., Tsai, S. J., Lee, G. Y., Mauck, R. L., Wells, R. G., & Burdick, J. A. (2016) · Scientific Reports · doi:10.1038/srep21387 · Cited by 218 · see citing works

Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway

Chakraborty, S., Njah, K., Pobbati, A. V., Lim, Y. B., Raju, A., Lakshmanan, M., Tergaonkar, V., Lim, C. T., & Hong, W. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.041 · Cited by 218 · see citing works

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

Cox, A. G., Hwang, K. L., Brown, K., Evason, K. J., Beltz, S., Tsomides, A., O’Connor, K., Galli, G. G., Yimlamai, D., Chhangawala, S., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3389 · Cited by 216 · see citing works

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

Hansen, C. G., Ng, Y. L. D., Lam, W.-L. M., Plouffe, S. W., & Guan, K.-L. (2015) · Cell Research · doi:10.1038/cr.2015.140 · Cited by 212 · see citing works

Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling

Hu, B., Castillo, E., Harewood, L., Ostano, P., Reymond, A., Dummer, R., Raffoul, W., Hoetzenecker, W., Hofbauer, G. F. L., & Dotto, G. P. (2012) · Cell · doi:10.1016/j.cell.2012.03.048 · Cited by 211 · see citing works

Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation

Tang, Y., Feinberg, T. Y., Keller, E. T., Li, X.-Y., & Weiss, S. J. (2016) · Nature Cell Biology · doi:10.1038/ncb3394 · Cited by 208 · see citing works

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

Liang, N., Zhang, C., Dill, P., Panasyuk, G., Pion, D., Koka, V., Gallazzini, M., Olson, E. N., Lam, H., Henske, E. P., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20140341 · Cited by 205 · see citing works

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

Foster, C. T., Gualdrini, F., & Treisman, R. (2017) · Genes &amp; Development · doi:10.1101/gad.304501.117 · Cited by 202 · see citing works

Angiomotins link F-actin architecture to Hippo pathway signaling

Mana‐Capelli, S., Paramasivam, M., Dutta, S., & McCollum, D. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-11-0701 · Cited by 202 · see citing works

Nanopillar force measurements reveal actin-cap-mediated YAP mechanotransduction

Shiu, J.-Y., Aires, L., Lin, Z., & Viola Vogel, B. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0030-y · Cited by 198 · see citing works

Dual role of YAP and TAZ in renewal of the intestinal epithelium

Imajo, M., Ebisuya, M., & Nishida, E. (2014) · Nature Cell Biology · doi:10.1038/ncb3084 · Cited by 194 · see citing works

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

Agostino, S. D., Sorrentino, G., Ingallina, E., Valenti, F., Ferraiuolo, M. A., Bicciato, S., Piazza, S., Strano, S., Sal, G. D., & Blandino, G. (2015) · EMBO Reports · doi:10.15252/embr.201540488 · Cited by 194 · see citing works

LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism

Zheng, X. M., Han, H., Liu, G., Ma, Y., Pan, R., Sang, L., Li, R., Yang, L.-J., Marks, J. R., Wang, W., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201797609 · Cited by 190 · see citing works

Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms

Ren, F., Zhang, L., & Jiang, J. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.046 · Cited by 181 · see citing works

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

Li, P., Silvis, M. R., Honaker, Y., Lien, W.-H., Arron, S. T., & Vasioukhin, V. (2016) · Genes &amp; Development · doi:10.1101/gad.274951.115 · Cited by 180 · see citing works

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesisPreprint

Cai, J., Maitra, A., Anders, R. A., Taketo, M. M., & Pan, D. (2015) · Genes & Development · doi:10.1101/gad.264515.115 · Cited by 175 · see citing works

Glucocorticoid receptor signalling activates YAP in breast cancer

Sorrentino, G., Ruggeri, N., Zannini, A., Ingallina, E., Bertolio, R., Marotta, C., Neri, C., Cappuzzello, E., Forcato, M., Rosato, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms14073 · Cited by 174 · see citing works

Structural and Functional Similarity between the Vgll1-TEAD and the YAP-TEAD Complexes

Pobbati, A. V., Chan, S. W., Lee, I., Song, H., & Hong, W. (2012) · Structure · doi:10.1016/j.str.2012.04.004 · Cited by 171 · see citing works

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

Noto, A., Vitis, C. D., Pisanu, M. E., Roscilli, G., Ricci, G., Catizone, A., Sorrentino, G., Chianese, G., Taglialatela‐Scafati, O., Trisciuoglio, D., et al. (2017) · Oncogene · doi:10.1038/onc.2017.75 · Cited by 166 · see citing works

Neuregulin 1–activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration

Haskins, J. W., Nguyen, D. X., & Stern, D. F. (2014) · Science Signaling · doi:10.1126/scisignal.2005770 · Cited by 165 · see citing works

Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways

Santinon, G., Pocaterra, A., & Dupont, S. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.11.004 · Cited by 164 · see citing works

Crosstalk between YAP/TAZ and Notch Signaling

Totaro, A., Castellan, M., Biagio, D. D., & Piccolo, S. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.03.001 · Cited by 163 · see citing works

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors

Lin, C., Pelissier, F. A., Zhang, H., Lakins, J. N., Weaver, V. M., Park, C., & LaBarge, M. A. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-07-0456 · Cited by 159 · see citing works

Cell Competition Drives the Growth of Intestinal Adenomas in Drosophila

Suijkerbuijk, S. J. E., Kolahgar, G., Kuciński, I., & Piddini, E. (2016) · Current Biology · doi:10.1016/j.cub.2015.12.043 · Cited by 158 · see citing works

Sensing the local environment: actin architecture and Hippo signalling

Gaspar, P., & Tapon, N. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.09.003 · Cited by 157 · see citing works

Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction

Nowell, C. S., Odermatt, P. D., Azzolin, L., Hoehnel, S., Wagner, E. F., Fantner, G. E., Lütolf, M. P., Barrandon, Y., Piccolo, S., & Radtke, F. (2015) · Nature Cell Biology · doi:10.1038/ncb3290 · Cited by 155 · see citing works

A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cellsPreprint

Chang, C., Goel, H. L., Gao, H., Pursell, B. M., Shultz, L. D., Greiner, D. L., Ingerpuu, S., Patarroyo, M., Cao, S., Lim, E., et al. (2015) · Genes & Development · doi:10.1101/gad.253682.114 · Cited by 153 · see citing works

Inactivation of a Gαs–PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

Iglesias‐Bartolomé, R., Torres, D., Marone, R., Feng, X., Martı́n, D., Simaan, M., Chen, M., Weinstein, L. S., Taylor, S. S., Molinolo, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3164 · Cited by 147 · see citing works

The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin

Furukawa, K. T., Yamashita, K., Sakurai, N., & Ohno, S. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.032 · Cited by 147 · see citing works

The Conserved Misshapen-Warts-Yorkie Pathway Acts in Enteroblasts to Regulate Intestinal Stem Cells in Drosophila

Li, Q., Li, S., Mana‐Capelli, S., Flach, R. J. R., Danai, L. V., Amcheslavsky, A., Nie, Y., Kaneko, S., Yao, X., Chen, X., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.09.012 · Cited by 142 · see citing works

Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock

Hubaud, A., Regev, I., Mahadevan, L., & Pourquié, O. (2017) · Cell · doi:10.1016/j.cell.2017.08.043 · Cited by 139 · see citing works

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

Nokin, M., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoï, A., Costanza, B., Smargiasso, N., Baiwir, D., et al. (2016) · eLife · doi:10.7554/elife.19375 · Cited by 137 · see citing works

The Spectrin cytoskeleton regulates the Hippo signalling pathway

Fletcher, G., Elbediwy, A., Khanal, I., Ribeiro, P. S., Tapon, N., & Thompson, B. J. (2015) · The EMBO Journal · doi:10.15252/embj.201489642 · Cited by 135 · see citing works

Hippo Signaling Regulates Pancreas Development through Inactivation of Yap

George, N. M., Day, C. E., Boerner, B. P., Johnson, R. L., & Sarvetnick, N. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.01034-12 · Cited by 135 · see citing works

Tead2 expression levels control Yap/Taz subcellular distribution, zyxin expression, and epithelial-mesenchymal transition

Diepenbruck, M., Waldmeier, L., Ivánek, R., Berninger, P., Arnold, P., van Nimwegen, E., & Christofori, G. (2014) · Journal of Cell Science · doi:10.1242/jcs.139865 · Cited by 132 · see citing works

Key Roles of AXL and MER Receptor Tyrosine Kinases in Resistance to Multiple Anticancer Therapies

Schoumacher, M., & Burbridge, M. F. (2017) · Current Oncology Reports · doi:10.1007/s11912-017-0579-4 · Cited by 132 · see citing works

Integrin signalling regulates YAP and TAZ to control skin homeostasis

Elbediwy, A., Vincent‐Mistiaen, Z. I., Spencer‐Dene, B., Stone, R. K., Boeing, S., Wculek, S. K., Cordero, J. B., Tan, E. H., Ridgway, R. A., Brunton, V., et al. (2016) · Journal of Cell Science · doi:10.1242/jcs.192518 · Cited by 127 · see citing works

The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells

Lucas, E. P., Khanal, I., Gaspar, P., et al. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201210073 · Cited by 127 · see citing works

YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis

Lin, C., Yao, E., Zhang, K., Jiang, X., Croll, S., Thompson-Peer, K. L., & Chuang, P. (2017) · eLife · doi:10.7554/elife.21130 · Cited by 127 · see citing works

mTORC2 Regulates Cardiac Response to Stress by Inhibiting MST1

Sciarretta, S., Zhai, P., Maejima, Y., Re, D. P. D., Nagarajan, N., Yee, D., Liu, T., Magnuson, M. A., Volpe, M., Frati, G., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.010 · Cited by 123 · see citing works

β1 integrin–dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin

Sabra, H., Brunner, M., Mandati, V., Wehrle‐Haller, B., Lallemand, D., Ribba, A., Chevalier, G., Guardiola, P., Block, M. R., & Bouvard, D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.808063 · Cited by 121 · see citing works

Spectrin regulates Hippo signaling by modulating cortical actomyosin activity

Deng, H., Wang, W., Yu, J., Zheng, Y., Qing, Y., & Pan, D. (2015) · eLife · doi:10.7554/elife.06567 · Cited by 113 · see citing works

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling

Oudhoff, M. J., Braam, M. J. S., Freeman, S. A., Wong, D., Rattray, D., Wang, J., Antignano, F., Snyder, K., Refaeli, I., Hughes, M. R., et al. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.03.002 · Cited by 110 · see citing works

Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators

Lavado, A., He, Y. Y., Paré, J., Neale, G. A. M., Olson, E. N., Giovannini, M., & Cao, X. (2013) · Development · doi:10.1242/dev.096537 · Cited by 108 · see citing works

Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

Lachowski, D., Cortés, E., Pink, D., Chronopoulos, A., Karim, S. A., Morton, J. P., & Hernández, A. E. D. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-02689-x · Cited by 105 · see citing works

Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest

Manderfield, L. J., Aghajanian, H. K., Engleka, K. A., Lim, L. Y., Lui, F., Jain, R., Li, L., Olson, E. N., & Epstein, J. A. (2015) · Development · doi:10.1242/dev.125807 · Cited by 100 · see citing works

Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ

Lladó, V., Nakanishi, Y., Durán, Á., Reina‐Campos, M., Shelton, P. M., Linares, J. F., Yajima, T., Campos, A. R., Aza‐Blanc, P., Leitges, M., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.007 · Cited by 98 · see citing works

Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness

Artinian, N., Cloninger, C., Holmes, B., Benavides-Serrato, A., Bashir, T., & Gera, J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.656587 · Cited by 95 · see citing works

YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme

Cotton, J. L., Li, Q., Ma, L., Park, J., Wang, J., Ou, J., Zhu, L. J., Ip, Y. T., Johnson, R. L., & Mao, J. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.08.019 · Cited by 92 · see citing works

Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis

de Lima, J. E., Bonnin, M.-A., Birchmeier, C., & Duprez, D. (2016) · eLife · doi:10.7554/elife.15593 · Cited by 89 · see citing works

YAP–IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis

Taniguchi, K., Moroishi, T., de Jong, P., Krawczyk, M., Grebbin, B. M., Luo, H.-Y., Xu, R.-H., Golob-Schwarzl, N., Schweiger, C., Wang, K.-P., et al. (2017) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1620290114 · Cited by 89 · see citing works

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells

Diamantopoulou, Z., White, G. R. M., Fadlullah, M. Z. H., Dreger, M., Pickering, K. A., Maltas, J., Ashton, G., MacLeod, R., Baillie, G. S., Kouskoff, V., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.03.007 · Cited by 87 · see citing works

TNFα-YAP/p65-HK2 axis mediates breast cancer cell migration

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Transcriptional integration of mitogenic and mechanical signals by Myc and YAPPreprint

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Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway

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Two-signal requirement for growth-promoting function of Yap in hepatocytes

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YAP1 is essential for osteoclastogenesis through a TEADs-dependent mechanism

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VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer

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A conserved MST1/2–YAP axis mediates Hippo signaling during lung growth

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Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system

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WIP Drives Tumor Progression through YAP/TAZ-Dependent Autonomous Cell Growth

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Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion

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Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exitPreprint

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Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor

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Regulation of cancer glutamine metabolism by EphA2 RTK-dependent activation of transcriptional co-activators YAP and TAZ

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β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

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Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65

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Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators

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Targeting integrin pathways: mechanisms and advances in therapy

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Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

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Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation

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YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

Planas-Paz, L., Sun, T., Pikiolek, M., Cochran, N. R., Bergling, S., Orsini, V., Yang, Z., Sigoillot, F., Jetzer, J., Syed, M., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.005 · Cited by 216 · see citing works

Angiogenesis in Chronic Inflammatory Skin Disorders

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Mechanical regulation of myofibroblast phenoconversion and collagen contraction

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Therapeutic targeting of TEAD transcription factors in cancer

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YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

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Biophysical regulation of macrophages in health and disease

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STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis

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Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

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Mechanosensing in macrophages and dendritic cells in steady-state and disease

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Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature

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Screening for YAP inhibitors identifies statins as modulators of fibrosis

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Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice

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YAP/TAZ signalling in colorectal cancer: lessons from consensus molecular subtypes

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Mechanical stiffness orchestrates distinct regulation of <scp>MRTFs</scp> and <scp>YAP</scp> / <scp>TAZ</scp> transcriptional cofactors in hepatocytes

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Intrinsic disorder of the extracellular matrix

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Diverse biological functions of extracellular collagen processing enzymes

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Downstream price-cap regulation and upstream market power

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A theoretical approach to analysis on the downstream and upstream road traffic flow rate of a single intersection

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