The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans
Open accessAbstract
Recent years have witnessed a sea change in our understanding of transcription regulation: whereas traditional models focused solely on the events that brought RNA polymerase II (Pol II) to a gene promoter to initiate RNA synthesis, emerging evidence points to the pausing of Pol II during early elongation as a widespread regulatory mechanism in higher eukaryotes. Current data indicate that pausing is particularly enriched at genes in signal-responsive pathways. Here the evidence for pausing of Pol II from recent high-throughput studies will be discussed, as well as the potential interconnected functions of promoter-proximally paused Pol II.
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Citations
Cites
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Self-citationA transcription reinitiation intermediate that is stabilized by activator
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The molecular hallmarks of epigenetic control
Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,635
Coactivator condensation at super-enhancers links phase separation and gene control
Sabari, B. R., Dall’Agnese, A., Boija, A., Klein, I. A., Coffey, E. L., Shrinivas, K., Abraham, B. J., Hannett, N. M., Zamudio, A. V., Manteiga, J. C., et al. (2018) · Science · doi:10.1126/science.aar3958 · Cited by 2,595
Transcriptional Regulation and Its Misregulation in Disease
Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.02.014 · Cited by 1,620
Local regulation of gene expression by lncRNA promoters, transcription and splicing
Engreitz, J. M., Haines, J. E., Perez, E. M., Munson, G., Chen, J., Kane, M., McDonel, P. E., Guttman, M., & Lander, E. S. (2016) · Nature · doi:10.1038/nature20149 · Cited by 1,253
Metadata
- Authors
- Adelman, K., & Lis, J. T.
- Venue
- Nature Reviews Genetics
- Published
- 2012-09-18
- Volume
- 13
- Issue
- 10
- Pages
- 720-731
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2064210252
- Cited by
- 1,181
- References
- 8
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
