The heritability of human disease: estimation, uses and abuses.

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Common SNPs explain a large proportion of the heritability for human height

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Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland

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Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease

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Editorial Perspective: Why is there such a mismatch between traditional heritability estimates and molecular genetic findings for behavioural traits?

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Sex differences in white adipose tissue expansion: emerging molecular mechanisms

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The missing heritability in type 1 diabetes

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A robust and unified framework for estimating heritability in twin studies using generalized estimating equations

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Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies

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Use of a Genealogical Database Demonstrates Heritability of Pulmonary Fibrosis

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Estimating heritable genetic contributions to innate immune and endocrine phenotypic correlations: A need to explore repeatability

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Heritability: What's the point? What is it not for? A human genetics perspective

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Identifying genetically driven clinical phenotypes using linear mixed models

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Retinal microvasculature: population epidemiology and concordance in Australian children aged 11–12 years and their parents

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Heritability of ambulatory and office blood pressure in the Swiss population

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Affective enhancement of working memory is maintained in depression.

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Heritability of language laterality assessed by functional transcranial Doppler ultrasound: a twin study

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‘There and Back Again’—Forward Genetics and Reverse Phenotyping in Pulmonary Arterial Hypertension

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Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes

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Why are education, socioeconomic position and intelligence genetically correlated?Preprint

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Gene-Lifestyle Interactions in Complex Diseases: Design and Description of the GLACIER and VIKING Studies

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Uncovering Evidence for Endocrine-Disrupting Chemicals That Elicit Differential Susceptibility through Gene-Environment Interactions

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Heritability of dental arches and occlusal characteristics: a systematic review and meta-analysis

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No large-effect low-frequency coding variation found for myocardial infarction

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Integrating Nonadditive Genomic Relationship Matrices into the Study of Genetic Architecture of Complex Traits

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Genome-Wide Association Analysis of Single-Breath D l CO

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Familial Segregation of Venous Thromboembolism in Sweden: A Nationwide Family Study of Heritability and Complex Segregation Analysis

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Prediction of the disease causal genes based on heterogeneous network and multi-feature combination method

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Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease

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Dissecting Motor Neuron Disease With Drosophila melanogaster

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Missing Heritability of Complex Traits and Diseases

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Prevalence and genetic parameters for cryptorchidism in Swedish-born Icelandic horses

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Genome-wide heritability analysis of severe malaria resistance reveals evidence of polygenic inheritance

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Genetics of bronchopulmonary dysplasia: When things do not match up, it is only the beginning

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Genetic and environmental impact on variation in the palatal dimensions in permanent dentition: a twin study

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Heritability estimates on Hodgkin’s lymphoma: a genomic- versus population-based approach

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Extending Previous cG×I Findings on 5-HTTLPR 's Moderation of Intervention Effects on Adolescent Substance Misuse Initiation

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Heritability of haemodynamics in the ascending aorta

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Advances and challenges in quantitative delineation of the genetic architecture of complex traits

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Tomato F3 lines development and its selection index based on narrow-sense heritability and factor analysis

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Estimating disease heritability from complex pedigrees allowing for ascertainment and covariates

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Uncovering the heritable components of multimorbidities and disease trajectories using a nationwide cohort

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Genetic effects on serum testosterone and sex hormone-binding globulin in men: a Korean twin and family study

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Heritability of glaucoma and glaucoma-related endophenotypes: systematic review and meta-analysis protocol

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Using partitioned heritability methods to explore genetic architecture

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Quantifying Genetic and Environmental Influence on Gray Matter Microstructure Using Diffusion MRI

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The ‘heritability’ of domestication and its functional partitioning in the pig

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Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review

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Chromosomal characteristics of salt stress heritable gene expression in the rice genome

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Population-Wide Genetic Risk Prediction of Complex Diseases: A Pilot Feasibility Study in Macau Population for Precision Public Healthcare Planning

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Using genetic designs to identify likely causal environmental contributions to psychopathology

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A simulation study for multifactorial genetic disorders to quantify the impact of polygenic risk scores on critical illness insurance

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Dissecting the genetic architecture of quantitative traits using genome‐wide identity‐by‐descent sharing

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Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart Family Study

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Identifying Cancer genes by combining two-rounds RWR based on multiple biological data

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Casual associations between brain structure and sarcopenia: A large‐scale genetic correlation and mendelian randomization study

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Evaluation of the Genetic Variance of Alzheimer’s Disease Explained by the Disease-Associated Chromosomal Regions

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Protein misfolding in endoplasmic reticulum stress with applications to renal diseases

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Association between a genetic index for lameness resistance and the incidence of claw horn lesions in Holstein cows

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The Dead Ends of Sociogenomics

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Rhesus macaque social functioning is paternally, but not maternally, inherited by sons: potential implications for autism

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Quantitative Genetics

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Dissecting heritability, environmental risk, and air pollution causal effects using > 50 million individuals in MarketScan

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Negligible heritability of language laterality assessed by functional transcranial Doppler ultrasound: a twin study

Bishop, D., & Bates, T. C. (2019) · Wellcome Open Research · doi:10.12688/wellcomeopenres.15524.1 · Cited by 6

Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies

Gusev, A. (2023) · Immunological Reviews · doi:10.1111/imr.13253 · Cited by 7

Heritabilities of Intraocular Pressure in the Population of Korea

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The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases

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Heritability estimation in case-control studies

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Genetic Regulation of Immunoglobulin G Glycosylation

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Mendelian Randomization and Infection: Pitfalls and Promises

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Environmental effects on brain functional networks in a juvenile twin population

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Influence of genetic and environmental factors on transverse growth

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Direct additive genetics and maternal effect contribute to the risk of Tourette disorder

Mahjani, B., Klei, L., Grice, A. B., Larsson, H., Hultman, C. M., Sandin, S., Devlin, B., Buxbaum, J. D., & Grice, D. E. (2023) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2022-330239 · Cited by 5

Haplotype-based analysis distinguishes maternal-fetal genetic contribution to pregnancy-related outcomes

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Genetic Variation Is the Major Determinant of Individual Differences in Leukocyte Endothelial Adhesion

Grassi, M. A., Rao, V. R., Winkler, K. P., Zhang, W., Bogaard, J. D., Chen, S., LaCroix, B. L., Lenkala, D., Rehman, J., Malik, A. B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087883 · Cited by 5

Study protocol to quantify the genetic architecture of sonographic cervical length and its relationship to spontaneous preterm birth

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A Behavior Genetic Analysis of Pleasant Events, Depressive Symptoms, and Their Covariation

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Genetics of Brain Aging – Twin Aging

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Detecting the dominance component of heritability in isolated and outbred human populations

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Significant Role for Maternal Genetic Nurture in the Risk Architecture of Attention Deficit Hyperactivity Disorder

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Surgically Treated Degenerative Lumbar Spine Diseases in Twins

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Prediction of genetic contributions to complex traits using whole genome sequencing data

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Genetic and Environmental Contributions to the Covariation Between Cardiometabolic Traits

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Inherited dreams: A twin study of future orientation and heritability among chinese adolescents

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What Have We Learned From Family-Based Studies About Spondyloarthritis?

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Cohort profile and heritability assessment of familial pancreatic cancer: a nation-wide study

Tan, M., Brusgaard, K., Gerdes, A., Mortensen, M. B., Detlefsen, S., de Muckadell, O. B. S., & Jøergensen, M. T. (2021) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2021.1937697 · Cited by 4

Family History of Breast Cancer Is Associated with Elevated Risk of Prostate Cancer: Evidence for Shared Genetic Risks

Chozas, A. C., Mahjani, B., & Rönnegård, L. (2021) · Human Heredity · doi:10.1159/000521215 · Cited by 4

Variational bayesian method of estimating variance components

Arakawa, A., Taniguchi, M., Hayashi, T., & Mikawa, S. (2016) · Animal Science Journal · doi:10.1111/asj.12514 · Cited by 4

Dominance Can Increase Genetic Variance After a Population Bottleneck: A Synthesis of the Theoretical and Empirical Evidence

Mularo, A. J., Bernal, X. E., & DeWoody, J. A. (2022) · Journal of Heredity · doi:10.1093/jhered/esac007 · Cited by 4

Estimate of Disease Heritability Using 7.4 million Familial Relationships Inferred from Electronic Health RecordsPreprint

Polubriaginof, F. C. G., Vanguri, R., Quinnies, K., Belbin, G. M., Yahi, A., Salmasian, H., Lorberbaum, T., Nwankwo, V., Li, L., Shervey, M., et al. (2018) · SSRN Electronic Journal · doi:10.1101/066068 · Cited by 4

Environmental and Genetic Influences on Developmental Outcomes Across the Domains of Language, Cognition, Motor Function, and Social Behavior

Schiavon, M., Burton, B. K., Hemager, N., Greve, A. N., Spang, K. S., Ellersgaard, D., Plessen, K. J., Jepsen, J. R. M., Thorup, A. A. E., Werge, T. M., et al. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70163 · Cited by 3

Fast heritability estimation based on MINQUE and batch training

Tang, M., Hou, T., Tong, X., Shen, X., Zhang, X., Wang, T., & Lu, Q. L. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac115 · Cited by 3

Integrating multi-layered biological priors to improve genomic prediction accuracy in beef cattle

Zhao, Z., Niu, Q., Wu, J., Wu, T., Xie, X., Wang, Z., Zhang, L., Gao, H., Gao, X. J., Xu, L., et al. (2024) · Biology Direct · doi:10.1186/s13062-024-00574-y · Cited by 4

Optimized phenotyping of complex morphological traits: enhancing discovery of common and rare genetic variants

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The Latent Class Twin Method

Baker, S. G. (2016) · Biometrics · doi:10.1111/biom.12460 · Cited by 3

Molecular Biomarkers of Health

Nehlin, J. O., & Andersen, O. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-52663-4_15 · Cited by 3

Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?

Sysojev, A. Ö., Frisell, T., Delcoigne, B., Saevarsdóttir, S., Askling, J., & Westerlind, H. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02873-z · Cited by 3

Heritability, genetic variation, and the number of risk SNPs effect on deep learning and polygenic risk scores AUC

Muneeb, M., Feng, S. F., & Henschel, A. (2022) · International Conference on Bioinformatics and Biomedical Technology (ICBBT) · doi:10.1145/3543377.3543387 · Cited by 3

Evaluation of genomic prediction of resistance to visceral white-spot disease in large yellow croaker (Larimichthys crocea)

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Familial liability to schizophrenia and mood disorders and cognitive impairment in psychosis

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Clinical Multigene Testing for Prostate Cancer

Berro, T., Barrett, E., & AlDubayan, S. H. (2021) · Urologic Clinics of North America · doi:10.1016/j.ucl.2021.03.002 · Cited by 3

Multidimensional Heritability Analysis of Neuroanatomical ShapePreprint

Ge, T., Reuter, M., Winkler, A. M., Holmes, A. J., Lee, P. H., Tirrell, L. S., Roffman, J. L., Buckner, R. L., Smoller, J. W., & Sabuncu, M. R. (2015) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/033407 · Cited by 3

Estimating disease heritability from complex pedigrees allowing for ascertainment and covariates

Speed, D., & Evans, D. M. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.02.010 · Cited by 9

Vom Unsinn der Erblichkeit

(2008) · Schweizer Archiv für Neurologie und Psychiatrie · doi:10.4414/sanp.2008.01918 · Cited by 2

How to estimate heritability, a guide for epidemiologistsPreprint

Barry, C.-J. S., Walker, V. M., Cheesman, R. C. G., Smith, G. D., Morris, T., & Davies, N. M. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2112.08840

Relatedness disequilibrium regression estimates heritability without environmental bias

Young, A. I., Frigge, M. L., Gudbjartsson, D. F., Thorleifsson, G., Bjornsdottir, G., Sulem, P., Masson, G., Thorsteinsdottir, U., Stefansson, K., & Kong, A. (2018) · Nature Genetics · doi:10.1038/s41588-018-0178-9 · Cited by 173

Assessing genetic influences on diseases and risk factors.

Austin, M. A. (2013) · CABI eBooks · doi:10.1079/9781780641812.0010