The DOI matches its Crossref record; 136 of the 137 references it cites were found in a registry or an index.
New genes as drivers of phenotypic evolution
Open accessAbstract
During the course of evolution, genomes acquire novel genetic elements as sources of functional and phenotypic diversity, including new genes that originated in recent evolution. In the past few years, substantial progress has been made in understanding the evolution and phenotypic effects of new genes. In particular, an emerging picture is that new genes, despite being present in the genomes of only a subset of species, can rapidly evolve indispensable roles in fundamental biological processes, including development, reproduction, brain function and behaviour. The molecular underpinnings of how new genes can develop these roles are starting to be characterized. These recent discoveries yield fresh insights into our broad understanding of biological diversity at refined resolution.
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“These data suggest extensive gene gain in cell lineages associated with early segregation of developmental potential leading to ctenophore-specific traits in structures controlling feeding, locomotion and integrative functions; a finding consistent with proposed 'orphan' genes contributing to variation in early development and evolution of novelties 22,23 .”
From The ctenophore genome and the evolutionary origins of neural systems (2014) · cites this paper as [22]
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The ctenophore genome and the evolutionary origins of neural systems
Moroz, L. L., Kocot, K. M., Citarella, M. R., Dosung, S., Norekian, T. P., Povolotskaya, I. S., Grigorenko, A. P., Dailey, C., Berezikov, E., Buckley, K. M., et al. (2014) · Nature · doi:10.1038/nature13400 · Cited by 716
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“…et al., 2009; Figure 4), fruit flies (Zhang, Dean, Brunet, & Long, 2004), apes and human (Baertsch, Diekhans, Kent, Haussler, & Brosius, 2008; Rosso et al., 2008), Arabidopsis (Matsuno et al., 2009) and many other organisms (Carelli et al., 2016; Chen et al., 2013; Kubiak & Makałowska, 2017).”
New Gene Evolution: Little Did We Know
Long, M., VanKuren, N. W., Chen, S., & Vibranovski, M. D. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133301 · Cited by 307
“However, studies in the past decade have found numerous young genes with important, and sometimes essential, functions at the molecular, cellular, and individual level (27).”
BackgroundSelf-citationOss, S. B. V., & Carvunis, A. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008160 · Cited by 302
Metadata
- Authors
- Chen, S., Krinsky, B. H., & Long, M.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Long, Manyuan
- Venue
- Nature Reviews Genetics
- Published
- 2013-08-16
- Volume
- 14
- Issue
- 9
- Pages
- 645-660
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC4236023
- OpenAlex
- W2057844822
- Cited by
- 428
- References
- 137
- Citations by year
- 2026: 21 · 2025: 34 · 2024: 64 · 2023: 46 · 2022: 30 · 2021: 28 · 2020: 30 · 2019: 41 · 2018: 22 · 2017: 26 · 2016: 36 · 2015: 17 · 2014: 27 · 2013: 6
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-08-22)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (1R01100768‑01A1)
- National Institute of General Medical Sciences (R01GM100768, T32GM007197)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- neofunctionalization, novel genes, gene birth, phenotypic evolution, genome evolution, gene duplication, developmental processes, reproduction, brain function, behavior, biodiversity, functional redundancy
- MeSH terms
- Animals, Behavior, Animal, Brain, Biological Evolution, Gene Expression Regulation, Genes, Humans, Phenotype, Plants, Reproduction, Sex Characteristics, Species Specificity, Evolution, Molecular, Biodiversity
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