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Cited by 307Chromosomal and Genetic VariationsEvolution and Genetic DynamicsGenomics and Phylogenetic Studies

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New Gene Evolution: Little Did We Know

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Long, Manyuan, VanKuren, Nicholas W., Chen, Sidi, Vibranovski, Maria D.·2013·Annual Review of Genetics
DOI 10.1146/annurev-genet-111212-133301PMC PMC4281893
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Abstract

Genes are perpetually added to and deleted from genomes during evolution. Thus, it is important to understand how new genes are formed and how they evolve to be critical components of the genetic systems that determine the biological diversity of life. Two decades of effort have shed light on the process of new gene origination and have contributed to an emerging comprehensive picture of how new genes are added to genomes, ranging from the mechanisms that generate new gene structures to the presence of new genes in different organisms to the rates and patterns of new gene origination and the roles of new genes in phenotypic evolution. We review each of these aspects of new gene evolution, summarizing the main evidence for the origination and importance of new genes in evolution. We highlight findings showing that new genes rapidly change existing genetic systems that govern various molecular, cellular, and phenotypic functions.

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Metadata

Authors
Long, M., VanKuren, N. W., Chen, S., & Vibranovski, M. D.
Affiliations
  • University of Chicago (US)
  • Massachusetts Institute of Technology (US)
  • Universidade de São Paulo (BR)
Corresponding author
Long, Manyuan
ORCID
Venue
Annual Review of Genetics
Publisher
Annual Reviews
Published
2013-11-23
Volume
47
Issue
1
Pages
307-333
ISSN
  • 0066-4197 (ISSN-L)
  • 1545-2948
DOI
10.1146/annurev-genet-111212-133301
PMC
PMC4281893
OpenAlex
W2151750549
Cited by
307
References
172
Citations by year
2026: 10 · 2025: 23 · 2024: 43 · 2023: 29 · 2022: 29 · 2021: 35 · 2020: 26 · 2019: 24 · 2018: 17 · 2017: 12 · 2016: 28 · 2015: 12 · 2014: 17 · 2013: 2
FWCI
2.11
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (R01GM100768, T32GM007197)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords
gene birth, genome evolution, gene structure evolution, phenotypic evolution, genetic systems, biodiversity
MeSH terms
Animals, Brain, Drosophila melanogaster, Forecasting, Gene Expression Regulation, Genes, Humans, Mammals, Models, Genetic, Phenotype, Phylogeny, Recombination, Genetic, Selection, Genetic, Sex Characteristics, Transcription, Genetic, Genes, Plant, Genes, Insect, Gene Dosage, Evolution, Molecular, Gene Duplication, RNA, Untranslated, Gene Transfer, Horizontal, Genetic Structures, Gene Regulatory Networks

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