Cited by 837RNA Research and SplicingGenomics and Chromatin DynamicsRNA and protein synthesis mechanisms

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Coupling mRNA processing with transcription in time and space

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Bentley, David L.·2014·Nature Reviews Genetics

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Abstract

Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the evolution of coupling mechanisms that coordinate transcription with mRNA capping, splicing, editing and 3' end formation. Recent experiments using sophisticated new methods for analysis of nascent RNA have provided important insights into the relative amount of co-transcriptional and post-transcriptional processing, the relationship between mRNA elongation and processing, and the role of the Pol II carboxy-terminal domain (CTD) in regulating these processes.

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Additional file 2 of A global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation
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Additional file 1 of A global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation
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Additional file 1 of Coupling of co-transcriptional splicing and 3’ end Pol II pausing during termination in Arabidopsis
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Additional file 4 of LABRAT reveals association of alternative polyadenylation with transcript localization, RNA binding protein expression, transcription speed, and cancer survival
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Additional file 3 of Coupling of co-transcriptional splicing and 3’ end Pol II pausing during termination in Arabidopsis
Zhou, S., Zhao, F., Zhu, D., Zhang, Q., Dai, Z., & Wu, Z. (2023) · Figshare · doi:10.6084/m9.figshare.24123750
Additional file 2 of LABRAT reveals association of alternative polyadenylation with transcript localization, RNA binding protein expression, transcription speed, and cancer survival
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Additional file 6 of WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells
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Authors: Bentley, D. L.
Affiliations: University of Colorado Anschutz (US)
Corresponding author: Bentley, David L.
ORCID: Bentley, David L.
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2014-02-11
Volume: 15
Issue: 3
Pages: 163-175
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg3662
PMC: PMC4304646
OpenAlex: W2040410152
Cited by: 828
References: 188
Citations by year: 2026: 47 · 2025: 49 · 2024: 53 · 2023: 64 · 2022: 68 · 2021: 77 · 2020: 90 · 2019: 88 · 2018: 64 · 2017: 74 · 2016: 73 · 2015: 57 · 2014: 24
FWCI: 7.16
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Cancer Research UK
National Institutes of Health
National Institute of General Medical Sciences (GM58163, R01GM058613, GM 063873, R01GM063873)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: post-transcriptional processing, RNA polymerase II, C-terminal domain, mRNA capping, mRNA splicing, RNA editing, 3' end formation, nascent RNA
MeSH terms: RNA Caps, RNA Polymerase II, RNA Splicing, RNA, Messenger, Transcription, Genetic

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