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Coupling mRNA processing with transcription in time and space
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Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the evolution of coupling mechanisms that coordinate transcription with mRNA capping, splicing, editing and 3' end formation. Recent experiments using sophisticated new methods for analysis of nascent RNA have provided important insights into the relative amount of co-transcriptional and post-transcriptional processing, the relationship between mRNA elongation and processing, and the role of the Pol II carboxy-terminal domain (CTD) in regulating these processes.
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“In addition, these different pre‐mRNA processing steps are functionally coupled to transcription. Indeed, all these steps are initiated co‐transcriptionally, thereby allowing the connection of transcription with mRNA maturation in time and space (Bentley, 2014).”
From RNA polymerase II speed: a key player in controlling and adapting transcriptome composition (2021) · cites this paper as Bentley, 2014
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Expansion of the eukaryotic proteome by alternative splicing
Nilsen, T. W., & Graveley, B. R. (2010) · Nature · doi:10.1038/nature08909 · Cited by 2,270
Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters
Core, L. J., Waterfall, J. J., & Lis, J. T. (2008) · Science · doi:10.1126/science.1162228 · Cited by 1,986
Mayr, C., & Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.06.016 · Cited by 1,613
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
Cramer, P., Bushnell, D. A., & Kornberg, R. D. (2001) · Science · doi:10.1126/science.1059493 · Cited by 1,247
Regulation of Alternative Splicing by Histone Modifications
Luco, R. F., Pan, Q., Tominaga, K., Blencowe, B. J., Pereira‐Smith, O. M., & Misteli, T. (2010) · Science · doi:10.1126/science.1184208 · Cited by 1,099
Komarnitsky, P. B., Cho, E., & Buratowski, S. (2000) · Genes & Development · doi:10.1101/gad.824700 · Cited by 1,098
R Loops: From Transcription Byproducts to Threats to Genome Stability
Aguilera, A., & García‐Muse, T. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.009 · Cited by 1,029
DNA sequence required for efficient transcription termination in yeast
Zaret, K. S., & Sherman, F. (1982) · Cell · doi:10.1016/0092-8674(82)90211-2 · Cited by 988
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
Shukla, S., Kavak, E., Gregory, M., Imashimizu, M., Shutinoski, B., Kashlev, M., Oberdoerffer, P., Sandberg, R., & Oberdoerffer, S. (2011) · Nature · doi:10.1038/nature10442 · Cited by 973
The C-terminal domain of RNA polymerase II couples mRNA processing to transcription
McCracken, S. A., Fong, N., Yankulov, K., Ballantyne, S. M., Pan, G., Greenblatt, J., Patterson, S. D., Wickens, M., & Bentley, D. L. (1997) · Nature · doi:10.1038/385357a0 · Cited by 925
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Kristensen, L. S., Andersen, M. S., Stagsted, L. V. W., Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0158-7 · Cited by 4,823
circRNA biogenesis competes with pre-mRNA splicing
Ashwal-Fluss, R., Meyer, M., Pamudurti, N. R., Ivanov, A., Bartok, O., Hanan, M., Evantal, N., Memczak, S., Rajewsky, N., & Kadener, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.019 · Cited by 3,083
The Biogenesis, Functions, and Challenges of Circular RNAs
Li, X., Yang, L. C., & Chen, L. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.034 · Cited by 2,060
The biogenesis and emerging roles of circular RNAs
Chen, L.-L. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.32 · Cited by 1,743
mRNAs, proteins and the emerging principles of gene expression control
Buccitelli, C., & Selbach, M. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0258-4 · Cited by 1,243
Context-dependent control of alternative splicing by RNA-binding proteins
Fu, X.-D., & Ares, M. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3778 · Cited by 1,044
mRNA-based therapeutics: powerful and versatile tools to combat diseases
Qin, S., Tang, X., Chen, Y., Chen, K., Fan, N., Xiao, W., Zheng, Q., Li, G., Teng, Y., Wu, M., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01007-w · Cited by 852
Organization and regulation of gene transcription
Cramer, P. (2019) · Nature · doi:10.1038/s41586-019-1517-4 · Cited by 793
Enhancers as non-coding RNA transcription units: recent insights and future perspectives
Li, W., Notani, D., & Rosenfeld, M. G. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.4 · Cited by 710
The Biogenesis of Nascent Circular RNAs
Zhang, Y., Xue, W., Li, X., Zhang, J., Chen, S., Zhang, J.-L., Yang, L., & Chen, L.-L. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.058 · Cited by 643
Transcription regulation by the Mediator complex
Soutourina, J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.115 · Cited by 635
A survey of the sorghum transcriptome using single-molecule long reads
Abdel‐Ghany, S. E., Hamilton, M., Jacobi, J. L., Ngam, P. B., Devitt, N. P., Schilkey, F., Ben‐Hur, A., & Reddy, A. S. N. (2016) · Nature Communications · doi:10.1038/ncomms11706 · Cited by 598
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA lossPreprint
Arun, G., Diermeier, S. D., Akerman, M., Chang, K.-C., Wilkinson, J. E., Hearn, S., Kim, Y., MacLeod, A. R., Krainer, A. R., Norton, L., et al. (2015) · Genes & Development · doi:10.1101/gad.270959.115 · Cited by 603
The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
Harlen, K. M., & Churchman, L. S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.10 · Cited by 499
Weirather, J. L., de Cesare, M., Wang, Y., Piazza, P., Sebastiano, V., Wang, X., Buck, D., & Au, K. F. (2017) · F1000Research · doi:10.12688/f1000research.10571.2 · Cited by 499
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Velthuis, A. J. W. T., & Fodor, E. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.87 · Cited by 479
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Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2016) · RNA Biology · doi:10.1080/15476286.2016.1271524 · Cited by 458
Born to run: control of transcription elongation by RNA polymerase II
Chen, F. X., Smith, E. R., & Shilatifard, A. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0010-5 · Cited by 447
Liang, D., Tatomer, D. C., Luo, Z., Wu, H., Yang, L. C., Chen, L., Cherry, S. R., & Wilusz, J. E. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.10.034 · Cited by 446
Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
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Xiao, R., Chen, J., Liang, Z., Luo, D., Chen, G., Lu, Z. J., Chen, Y., Zhou, B., Li, H., Du, X., et al. (2019) · Cell · doi:10.1016/j.cell.2019.06.001 · Cited by 382
RNA promotes the formation of spatial compartments in the nucleus
Quinodoz, S. A., Jachowicz, J. W., Bhat, P., Ollikainen, N., Banerjee, A. K., Goronzy, I. N., Blanco, M. R., Chovanec, P., Chow, A. Y., Markaki, Y., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.014 · Cited by 395
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Zhou, K. I., Shi, H., Lyu, R., Wylder, A. C., Matuszek, Ż., Pan, J. N., He, C., Parisien, M., & Pan, T. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.005 · Cited by 392
The Diversity of Long Noncoding RNAs and Their Generation
Wu, H., Yang, L. C., & Chen, L. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.05.004 · Cited by 386
Polyglutamine spinocerebellar ataxias — from genes to potential treatments
Paulson, H. L., Shakkottai, V. G., Clark, H. B., & Orr, H. T. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.92 · Cited by 385
Enhancer RNAs are an important regulatory layer of the epigenome
Sartorelli, V., & Lauberth, S. M. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-0446-0 · Cited by 380
Mayer, A., di Iulio, J., Maleri, S., Eser, U., Vierstra, J., Reynolds, A., Sandstrom, R., Stamatoyannopoulos, J. A., & Churchman, L. S. (2015) · Cell · doi:10.1016/j.cell.2015.03.010 · Cited by 367
MYC protein interactors in gene transcription and cancer
Lourenco, C., Resetca, D., Redel, C., Lin, P., MacDonald, A. S., Ciaccio, R., Kenney, T. M. G., Wei, Y., Andrews, D. W., Sunnerhagen, M., et al. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00367-9 · Cited by 351
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
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Whittaker, C., & Dean, C. (2017) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100616-060546 · Cited by 346
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Mayr, C. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.012 · Cited by 343
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Dubbury, S. J., Boutz, P. L., & Sharp, P. A. (2018) · Nature · doi:10.1038/s41586-018-0758-y · Cited by 318
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Sciarrillo, R., Wojtuszkiewicz, A., Assaraf, Y. G., Jansen, G., Kaspers, G. J. L., Giovannetti, E., & Cloos, J. J. (2020) · Drug Resistance Updates · doi:10.1016/j.drup.2020.100728 · Cited by 317
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Yang, L. C., Wilusz, J. E., & Chen, L. (2022) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120420-125117 · Cited by 308
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Bludau, I., & Aebersold, R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0231-2 · Cited by 297
The multiple functions of RNA helicases as drivers and regulators of gene expression
Bourgeois, C. F., Mortreux, F., & Auboeuf, D. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.50 · Cited by 297
Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate
Fong, N., Kim, H., Zhou, Y., Ji, X., Qiu, J., Saldi, T., Diener, K., Jones, K., Fu, X.-D., & Bentley, D. L. (2014) · Genes & Development · doi:10.1101/gad.252106.114 · Cited by 287
Self-citationKrajewska, M., Dries, R., Grassetti, A. V., Dust, S., Gao, Y., Huang, H., Sharma, B., Day, D. S., Kwiatkowski, N., Pomaville, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09703-y · Cited by 281
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Jeong-Yu, S. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.2319 · Cited by 286
Machine Learning in Genomic Medicine: A Review of Computational Problems and Data Sets
Leung, M. K. K., Delong, A., Alipanahi, B., & Frey, B. J. (2015) · Proceedings of the IEEE · doi:10.1109/jproc.2015.2494198 · Cited by 284
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
Rogalska, M. E., Vivori, C., & Valcárcel, J. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00556-8 · Cited by 284
Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing
Saldi, T. K., Cortázar, M. A., Sheridan, R. M., & Bentley, D. L. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.04.017 · Cited by 266
Self-citationGoing circular: history, present, and future of circRNAs in cancer
Pisignano, G., Michael, D. C., Visal, T. H., Pîrlog, R., Ladomery, M., & Călin, G. A. (2023) · Oncogene · doi:10.1038/s41388-023-02780-w · Cited by 272
Louloupi, A., Ntini, E., Conrad, T., & Ørom, U. A. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.077 · Cited by 239
Control of mammalian gene expression by selective mRNA export
Wickramasinghe, V. O., & Laskey, R. A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4010 · Cited by 238
Chromatin-associated RNAs as facilitators of functional genomic interactions
Li, X., & Fu, X. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0135-1 · Cited by 236
Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanopores
Drexler, H. L., Choquet, K., & Churchman, L. S. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.11.017 · Cited by 237
Nanopore Technology and Its Applications in Gene Sequencing
Lin, B., Hui, J., & Mao, H. (2021) · Biosensors · doi:10.3390/bios11070214 · Cited by 243
Guo, R., Zheng, L., Park, J. W., Lyu, R., Chen, H., Jiao, F., Xu, W., Mu, S.-R., Wen, H., Qiu, J., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.022 · Cited by 237
Kinetic competition during the transcription cycle results in stochastic RNA processing
Coulon, A., Ferguson, M., de Turris, V., Palangat, M., Chow, C. C., & Larson, D. R. (2014) · eLife · doi:10.7554/elife.03939 · Cited by 229
Cortazar, M. A., Sheridan, R. M., Erickson, B., Fong, N., Glover-Cutter, K., Brannan, K., & Bentley, D. L. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.031 · Cited by 227
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Roles of circular RNAs in immune regulation and autoimmune diseases
Zhou, Z. G., Sun, B., Huang, S., & Zhao, L. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1744-5 · Cited by 224
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Bogard, N., Linder, J., Rosenberg, A. B., & Seelig, G. (2019) · Cell · doi:10.1016/j.cell.2019.04.046 · Cited by 215
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Chabot, B., & Shkreta, L. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201510032 · Cited by 220
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Voong, L. N., Xi, L., Sebeson, A. C., Xiong, B., Wang, J., & Wang, X. (2016) · Cell · doi:10.1016/j.cell.2016.10.049 · Cited by 203
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Debès, C., Papadakis, A., Grönke, S., Karalay, Ö., Tain, L. S., Mizi, A., Nakamura, S., Hahn, O., Weigelt, C., Josipovic, N., et al. (2023) · Nature · doi:10.1038/s41586-023-05922-y · Cited by 214
RNA polymerase II speed: a key player in controlling and adapting transcriptome composition
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“Phosphorylation on Ser5 is normally high at the 5 0 ends of genes where it facilitates mRNA capping, whereas Ser2 phosphorylation is high at 3 0 ends where it is important for mRNA 3 0 end formation (Bura-towski, 2009; Heidemann et al , 2013; Bentley, 2014).”
Hage, A. E., Webb, S., Kerr, A. R. W., & Tollervey, D. W. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004716 · Cited by 213
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Sun, J., Li, B., Shu, C., Ma, Q., & Wang, J. (2020) · Molecular Cancer · doi:10.1186/s12943-019-1121-0 · Cited by 195
Transcription Dynamics in Living Cells
Lenstra, T. L., Rodriguez, J., Chen, H., & Larson, D. R. (2016) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-062215-010838 · Cited by 186
Targeting mRNA processing as an anticancer strategy
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Co-transcriptional splicing regulates 3′ end cleavage during mammalian erythropoiesis
Reimer, K. A., Mimoso, C. A., Adelman, K., & Neugebauer, K. M. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.018 · Cited by 180
Noncoding RNA and its associated proteins as regulatory elements of the immune system
Turner, M., Galloway, A., & Vigorito, E. (2014) · Nature Immunology · doi:10.1038/ni.2887 · Cited by 174
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Nilson, K. A., Guo, J., Turek, M. E., Brogie, J. E., Delaney, E., Luse, D. S., & Price, D. H. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.032 · Cited by 170
RNA editing in nascent RNA affects pre-mRNA splicingPreprint
Hsiao, Y.-H. E., Bahn, J. H., Yang, Y., Lin, X., Tran, S. S., Yang, E.-W., Quinones-Valdez, G., & Xiao, X. G. (2018) · Genome Research · doi:10.1101/gr.231209.117 · Cited by 166
The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3′ processing
Abe, K., Yamamoto, R., Franke, V., Cao, M., Suzuki, Y., Suzuki, M. G., Vlahoviček, K., Svoboda, P., Schultz, R. M., & Aoki, F. (2015) · The EMBO Journal · doi:10.15252/embj.201490648 · Cited by 168
The core promoter: At the heart of gene expression
Danino, Y. M., Even, D. Y., Ideses, D., & Juven‐Gershon, T. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.04.003 · Cited by 179
The RNA Splicing Response to DNA Damage
Shkreta, L., & Chabot, B. (2015) · Biomolecules · doi:10.3390/biom5042935 · Cited by 156
Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications
Licht, K., & Jantsch, M. F. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201511041 · Cited by 154
Harlen, K. M., Trotta, K. L., Smith, E. E., Mosaheb, M. M., Fuchs, S. M., & Churchman, L. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.010 · Cited by 150
Heptad-Specific Phosphorylation of RNA Polymerase II CTD
Schüller, R., Forné, I., Straub, T., Schreieck, A., Texier, Y., Shah, N., Decker, T.-M., Cramer, P., Imhof, A., & Eick, D. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.003 · Cited by 150
Transcriptional Signatures of Aging
Stegeman, R., & Weake, V. M. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.06.019 · Cited by 146
Regulation of RNA editing by RNA-binding proteins in human cells
Quinones-Valdez, G., Tran, S. S., Jun, H.-I., Bahn, J. H., Yang, E.-W., Zhan, L., Brümmer, A., Wei, X., Nostrand, E. L. V., Pratt, H., et al. (2019) · Communications Biology · doi:10.1038/s42003-018-0271-8 · Cited by 139
The RNAs of RNA-directed DNA methylation
Wendte, J. M., & Pikaard, C. S. (2017) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.08.004 · Cited by 140
SCAF4 and SCAF8, mRNA Anti-Terminator Proteins
Gregersen, L. H., Mitter, R., Ugalde, A. P., Nojima, T., Proudfoot, N. J., Agami, R., Stewart, A., & Svejstrup, J. Q. (2019) · Cell · doi:10.1016/j.cell.2019.04.038 · Cited by 140
Post-transcriptional splicing of nascent RNA contributes to widespread intron retention in plants
Jia, J., Long, Y., Zhang, H., Li, Z., Liu, Z., Zhao, Y., Lu, D., Jin, X., Deng, X. M., Xia, R., et al. (2020) · Nature Plants · doi:10.1038/s41477-020-0688-1 · Cited by 137
Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle
Kinouchi, K., Magnan, C., Ceglia, N., Liu, Y., Cervantes, M., Pastore, N., Huynh, T., Ballabio, A., Baldi, P., Masri, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.077 · Cited by 135
The RNA Polymerase II CTD: The Increasing Complexity of a Low-Complexity Protein Domain
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Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development
Tang, S. J., Shen, H., An, Ö., Hong, H., Li, J., Song, Y., Han, J., Tay, D. J. T., Ng, V. H. E., Molías, F. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14621-5 · Cited by 134
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Quaresma, A. J. C., Bugai, A., & Barborič, M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw585 · Cited by 134
Yu, Y., & Reed, R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506282112 · Cited by 132
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Huang, J., Gu, L., Zhang, Y., Yan, T., Kong, G., Kong, L., Guo, B., Qiu, M., Wang, Y., Jing, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02233-5 · Cited by 125
DNA methylation directs microRNA biogenesis in mammalian cells
Glaich, O., Parikh, S., Bell, R. E., Mekahel, K., Donyo, M., Leader, Y., Shayevitch, R., Sheinboim, D., Yannai, S., Hollander, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13527-1 · Cited by 124
Phizicky, E. M., & Hopper, A. K. (2023) · RNA · doi:10.1261/rna.079620.123 · Cited by 122
Sheridan, R. M., Fong, N., D’Alessandro, A., & Bentley, D. L. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.10.031 · Cited by 123
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Metadata
- Authors
- Bentley, D. L.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Bentley, David L.
- ORCID
- Bentley, David L.
- Venue
- Nature Reviews Genetics
- Published
- 2014-02-11
- Volume
- 15
- Issue
- 3
- Pages
- 163-175
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC4304646
- OpenAlex
- W2040410152
- Cited by
- 828
- References
- 188
- Citations by year
- 2026: 47 · 2025: 49 · 2024: 53 · 2023: 64 · 2022: 68 · 2021: 77 · 2020: 90 · 2019: 88 · 2018: 64 · 2017: 74 · 2016: 73 · 2015: 57 · 2014: 24
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Cancer Research UK
- National Institutes of Health
- National Institute of General Medical Sciences (GM58163, R01GM058613, GM 063873, R01GM063873)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- post-transcriptional processing, RNA polymerase II, C-terminal domain, mRNA capping, mRNA splicing, RNA editing, 3' end formation, nascent RNA
- MeSH terms
- RNA Caps, RNA Polymerase II, RNA Splicing, RNA, Messenger, Transcription, Genetic
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