The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Every amino acid matters: essential contributions of histone variants to mammalian development and disease
Open accessAbstract
Despite a conserved role for histones as general DNA packaging agents, it is now clear that another key function of these proteins is to confer variations in chromatin structure to ensure dynamic patterns of transcriptional regulation in eukaryotes. The incorporation of histone variants is particularly important to this process. Recent knockdown and knockout studies in various cellular systems, as well as direct mutational evidence from human cancers, now suggest a crucial role for histone variant regulation in processes as diverse as differentiation and proliferation, meiosis and nuclear reprogramming. In this Review, we provide an overview of histone variants in the context of their unique functions during mammalian germ cell and embryonic development, and examine the consequences of aberrant histone variant regulation in human disease.
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Cites
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Cited by
Pan, R.-Y., He, L., Zhang, J., Liu, X., Liao, Y., Gao, J., Liao, Y., Yan, Y., Li, Q., Zhou, X., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.02.013 · Cited by 862
Epigenetic regulation of ageing: linking environmental inputs to genomic stability
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The roles of histone variants in fine-tuning chromatin organization and function
Martire, S., & Banaszynski, L. A. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0262-8 · Cited by 392
The emerging field of epigenetics in neurodegeneration and neuroprotection
Hwang, J.-Y., Aromolaran, K. A., & Zukin, R. S. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.46 · Cited by 346
Single-cell chromatin modification profiling reveals increased epigenetic variations with aging
Cheung, P., Vallania, F., Warsinske, H. C., Donato, M., Schaffert, S., Chang, S. E., Dvorak, M., Dekker, C. L., Davis, M. M., Utz, P. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.079 · Cited by 323
“Cell-cycle-independent incorporation of histone variants further diversifies chromatin states and provides an additional layer of regulation to DNA-templated processes (Maze et al., 2014).”
Metadata
- Authors
- Maze, I., Noh, K.-M., Soshnev, A. A., & Allis, C. D.
- Venue
- Nature Reviews Genetics
- Published
- 2014-03-11
- Volume
- 15
- Issue
- 4
- Pages
- 259-271
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2007639313
- Cited by
- 349
- References
- 144
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Maze, I., Noh, K.-M., Soshnev, A. A., & Allis, C. D. (2014). Every amino acid matters: essential contributions of histone variants to mammalian development and disease. Nature Reviews Genetics. https://doi.org/10.1038/nrg3673
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