The Polycomb complex PRC2 and its mark in life

High-Resolution Profiling of Histone Methylations in the Human Genome

Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845 · see citing works

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361 · see citing works

Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs

Rinn, J. L., Kertesz, M., Wang, J. K., Squazzo, S. L., Xu, X. H., Brugmann, S. A., Goodnough, L. H., Helms, J. A., Farnham, P., Segal, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.022 · Cited by 4,246 · see citing works

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129 · see citing works

A gene complex controlling segmentation in Drosophila

Lewis, E. B. (1978) · Nature · doi:10.1038/276565a0 · Cited by 3,813 · see citing works

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 1× · see citing works

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872 · see citing works

The polycomb group protein EZH2 is involved in progression of prostate cancer

Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717 · see citing works

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536 · see citing works

Polycomb complexes repress developmental regulators in murine embryonic stem cells

Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,518 · see citing works

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R., Chevalier, B. S., Johnstone, S. E., Cole, M. F., Isono, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,238 · see citing works

Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation

Zemach, A., McDaniel, I. E., Silva, P., & Zilberman, D. (2010) · Science · doi:10.1126/science.1186366 · Cited by 1,796 · see citing works

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

Morin, R. D., Johnson, N. A., Severson, T., Mungall, A. J. J., An, J., Goya, R., Paul, J. E., Boyle, M., Woolcock, B. W., Kuchenbauer, F. C., et al. (2010) · Nature Genetics · doi:10.1038/ng.518 · Cited by 1,670 · see citing works

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Kleer, C. G., Cao, Q., Varambally, S., Shen, R., Ota, I., Tomlins, S. A., Ghosh, D., Sewalt, R. G. A. B., Otte, A. P., Hayes, D. F., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1933744100 · Cited by 1,649 · see citing works

Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome

Zhao, J. C., Sun, B. K., Erwin, J. A., Song, J., & Lee, J. T. (2008) · Science · doi:10.1126/science.1163045 · Cited by 1,580 · see citing works

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

Yap, K. L., Li, S., Muñoz-Cabello, A. M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M. J., & Zhou, M.-M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.021 · Cited by 1,391 · see citing works

Mechanisms of Polycomb gene silencing: knowns and unknowns

Simon, J. A., & Kingston, R. E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2763 · Cited by 1,320 · see citing works

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsPreprint

Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., & Helin, K. (2006) · Genes & Development · doi:10.1101/gad.381706 · Cited by 1,258 · see citing works

Role of the polycomb protein EED in the propagation of repressive histone marks

Margueron, R., Justin, N., Ohno, K., Sharpe, M. L., Son, J., Drury, W. J., Voigt, P., Martin, S. R., Taylor, W. R., Marco, V. D., et al. (2009) · Nature · doi:10.1038/nature08398 · Cited by 1,203 · see citing works

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.

Bracken, A. P., Pasini, D., Capra, M., Prosperini, E., Colli, E., & Helin, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg542 · Cited by 1,196 · see citing works

Kcnq1ot1 Antisense Noncoding RNA Mediates Lineage-Specific Transcriptional Silencing through Chromatin-Level Regulation

Pandey, R. R., Mondal, T., Mohammad, F., Enroth, S., Redrup, L., Komorowski, J., Nagano, T., Mancini‐DiNardo, D., & Kanduri, C. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.022 · Cited by 1,192 · see citing works

Role of Histone H3 Lysine 27 Methylation in X Inactivation

Plath, K., Fang, J., Mlynarczyk‐Evans, S., Cao, R., Worringer, K. A., Wang, H., de la Cruz, C. C., Otte, A. P., Panning, B., & Zhang, Y. (2003) · Science · doi:10.1126/science.1084274 · Cited by 1,190 · see citing works

Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin

Peters, A. H. F. M., Kubicek, S., Mechtler, K., O’Sullivan, R. J., Derijck, A. A. H. A., Perez-Burgos, L., Kohlmaier, A., Opravil, S., Tachibana, M., Shinkai, Y., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00477-5 · Cited by 1,148 · see citing works

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

Ernst, T., Chase, A. J., Score, J., Hidalgo-Curtis, C. E., Bryant, C., Jones, A. V., Waghorn, K., Zoi, K., Ross, F. M., Reiter, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.621 · Cited by 1,139 · see citing works

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

Shen, X., Liu, Y., Hsu, Y.-J., Fujiwara, Y., Kim, J., Mao, X., Yuan, G.-C., & Orkin, S. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.016 · Cited by 1,021 · see citing works

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

Ku, M., Koche, R. P., Rheinbay, E., Mendenhall, E. M., Endoh, M., Mikkelsen, T. S., Aiden, A. P., Nusbaum, C., Xie, X. S., Chi, A. S., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000242 · Cited by 996 · see citing works

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

Mohn, F., Weber, M., Rebhan, M., Roloff, T. C., Richter, J., Stadler, M. B., Bibel, M., & Schübeler, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.007 · Cited by 912 · see citing works

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

Margueron, R., Li, G., Sarma, K., Blais, A., Zavadil, J., Woodcock, C. L. F., Dynlacht, B. D., & Reinberg, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.11.004 · Cited by 889 · see citing works

The Polycomb group proteins bind throughout the <i>INK4A-ARF</i> locus and are disassociated in senescent cells

Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., et al. (2007) · Genes &amp; Development · doi:10.1101/gad.415507 · Cited by 850 · see citing works

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

Scheuermann, J. C., Alonso, A. G. D. A., Oktaba, K., Ly‐Hartig, N., McGinty, R. K., Fraterman, S., Wilm, M. S., Muir, T. W., & Müller, J. (2010) · Nature · doi:10.1038/nature08966 · Cited by 816 · see citing works

SUZ12 Is Required for Both the Histone Methyltransferase Activity and the Silencing Function of the EED-EZH2 Complex

Cao, R., & Zhang, Y. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.020 · Cited by 809 · see citing works

Distinct epigenomic landscapes of pluripotent and lineage-committed human cells

Hawkins, R. D., Hon, G. C., Lee, L. K., Ngo, Q., Lister, R., Pelizzola, M., Edsall, L. E., Kuan, S., Luu, Y., Klugman, S., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.018 · Cited by 806 · see citing works

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

Nikoloski, G., Langemeijer, S. M. C., Kuiper, R. P., Knops, R., Massop, M., Tönnissen, E., van der Heijden, A., Scheele, T. N., Vandenberghe, P., de Witte, T., et al. (2010) · Nature Genetics · doi:10.1038/ng.620 · Cited by 754 · see citing works

Chromatin structure and the inheritance of epigenetic information

Margueron, R., & Reinberg, D. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2752 · Cited by 733 · see citing works

A model for transmission of the H3K27me3 epigenetic mark

Hansen, K. H., Bracken, A. P., Pasini, D., Dietrich, N., Gehani, S. S., Monrad, A., Rappsilber, J., Lerdrup, M., & Helin, K. (2008) · Nature Cell Biology · doi:10.1038/ncb1787 · Cited by 720 · see citing works

Whole-Genome Analysis of Histone H3 Lysine 4 and Lysine 27 Methylation in Human Embryonic Stem Cells

Pan, G., Tian, S., Nie, J., Yang, C., Ruotti, V., Wei, H., Jonsdottir, G. A., Stewart, R., & Thomson, J. A. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.003 · Cited by 711 · see citing works

The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation

Pasini, D., Bracken, A. P., Hansen, J. B., Capillo, M., & Helin, K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01432-06 · Cited by 696 · see citing works

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

Stock, J. K., Giadrossi, S., Casanova, M., Brookes, E., Vidal, M., Koseki, H., Brockdorff, N., Fisher, A. G., & Pombo, A. (2007) · Nature Cell Biology · doi:10.1038/ncb1663 · Cited by 650 · see citing works

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

Cui, K., Zang, C., Roh, T., Schones, D. E., Childs, R. W., Peng, W., & Zhao, K. (2009) · Cell stem cell · doi:10.1016/j.stem.2008.11.011 · Cited by 620 · see citing works

Whole-Genome Mapping of Histone H3 Lys4 and 27 Trimethylations Reveals Distinct Genomic Compartments in Human Embryonic Stem Cells

Zhao, X. D., Han, X., Chew, J. L., Liu, J., Chiu, K. P., Choo, A. B. H., Orlov, Y. L., Sung, W.-K. K., Shahab, A., Kuznetsov, V. A., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.08.004 · Cited by 616 · see citing works

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement

Su, I.-H., Basavaraj, A., Krutchinsky, A. N., Hobert, O., Ullrich, A., Chait, B. T., & Tarakhovsky, A. (2002) · Nature Immunology · doi:10.1038/ni876 · Cited by 614 · see citing works

Genome-wide analysis of Polycomb targets in Drosophila melanogaster

Schwartz, Y. B., Kahn, T. G., Nix, D. A., Li, X., Bourgon, R., Biggin, M. D., & Pirrotta, V. (2006) · Nature Genetics · doi:10.1038/ng1817 · Cited by 610 · see citing works

Facultative Heterochromatin: Is There a Distinctive Molecular Signature?

Trojer, P., & Reinberg, D. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.011 · Cited by 609 · see citing works

Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem Cells

Ezhkova, E., Pasolli, H. A., Parker, J. S., Stokes, N., Su, I.-H., Hannon, G. J., Tarakhovsky, A., & Fuchs, E. V. (2009) · Cell · doi:10.1016/j.cell.2008.12.043 · Cited by 599 · see citing works

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiationPreprint

G, C., Padova, M. D., GE, L., Lyons, G. E., & Sartorelli, V. (2004) · Genes & Development · doi:10.1101/gad.1241904 · Cited by 595 · see citing works

CBP-mediated acetylation of histone H3 lysine 27 antagonizesDrosophilaPolycomb silencing

Tie, F., Banerjee, R., Stratton, C. A., Prasad-Sinha, J., Stepanik, V. A., Zlobin, A., Dı́az, M. O., Scacheri, P. C., & Harte, P. J. (2009) · Development · doi:10.1242/dev.037127 · Cited by 575 · see citing works

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

Pasini, D., Cloos, P. A., Walfridsson, J., Olsson, L., Bukowski, J., Johansen, J. V., Bak, M., Tommerup, N., Rappsilber, J., & Helin, K. (2010) · Nature · doi:10.1038/nature08788 · Cited by 562 · see citing works

Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

Eskeland, R., Leeb, M., Grimes, G. R., Kress, C., Boyle, S., Sproul, D., Gilbert, N., Fan, Y., Skoultchi, A. I., Wutz, A., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.02.032 · Cited by 553 · see citing works

Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells

Peng, J. C., Valouev, A., Swigut, T., Zhang, J., Zhao, Y., Sidow, A., & Wysocka, J. (2009) · Cell · doi:10.1016/j.cell.2009.12.002 · Cited by 533 · see citing works

Jarid2 and PRC2, partners in regulating gene expressionPreprint

Li, G., Margueron, R., Ku, M., Chambon, P., Bernstein, B., & Reinberg, D. (2010) · Genes & Development · doi:10.1101/gad.1886410 · Cited by 499 · see citing works

Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells

Shen, X., Kim, W., Fujiwara, Y., Simon, M. D., Liu, Y., Mysliwiec, M. R., Yuan, G., Lee, Y., & Orkin, S. H. (2009) · Cell · doi:10.1016/j.cell.2009.12.003 · Cited by 426 · see citing works

Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice

Schuettengruber, B., & Cavalli, G. (2009) · Development · doi:10.1242/dev.033902 · Cited by 424 · see citing works

Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing

Schoeftner, S., Sengupta, A. K., Kubicek, S., Mechtler, K., Spahn, L., Koseki, H., Jenuwein, T., & Wutz, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601187 · Cited by 399 · see citing works

Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNAPreprint

Kaneko, S., Li, G., Son, J., Xu, C., Margueron, R., Neubert, T. A., & Reinberg, D. (2010) · Genes & Development · doi:10.1101/gad.1983810 · Cited by 399 · see citing works

A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activitiesPreprint

Klymenko, T., Papp, B., Fischle, W., Köcher, T., Schelder, M., Fritsch, C., Wild, B., Wilm, M. S., & Müller, J. (2006) · Genes & Development · doi:10.1101/gad.377406 · Cited by 397 · see citing works

A Chromosomal Memory Triggered by Xist Regulates Histone Methylation in X Inactivation

Kohlmaier, A., Savarese, F., Lachner, M., Martens, J. H. A., Jenuwein, T., & Wutz, A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020171 · Cited by 386 · see citing works

Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

Tolhuis, B., Muijrers, I., de Wit, E., Teunissen, H., Talhout, W., van Steensel, B., & van Lohuizen, M. (2006) · Nature Genetics · doi:10.1038/ng1792 · Cited by 380 · see citing works

Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2

Kanhere, A., Viiri, K. M., Araújo, C. C., Rasaiyaah, J., Bouwman, R. D., Whyte, W. A., Pereira, C., Brookes, E., Walker, K., Bell, G. W., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.019 · Cited by 370 · see citing works

Chromatin signature of embryonic pluripotency is established during genome activation

Vastenhouw, N. L., Zhang, Y., Woods, I. G., Imam, F. B., Regev, A., Liu, X. S., Rinn, J. L., & Schier, A. F. (2010) · Nature · doi:10.1038/nature08866 · Cited by 367 · see citing works

Polycomb complexes act redundantly to repress genomic repeats and genesPreprint

Leeb, M., Pasini, D., Novatchkova, M., Jaritz, M., Helin, K., & Wutz, A. (2010) · Genes & Development · doi:10.1101/gad.544410 · Cited by 342 · see citing works

H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment

Creyghton, M. P., Markoulaki, S., Levine, S. S., Hanna, J. H., Lodato, M. A., Sha, K., Young, R. A., Jaenisch, R., & Boyer, L. A. (2008) · Cell · doi:10.1016/j.cell.2008.09.056 · Cited by 340 · see citing works

Polycomb Repressive Complex 2 Is Dispensable for Maintenance of Embryonic Stem Cell Pluripotency

Chamberlain, S. J., Yee, D., & Magnuson, T. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0102 · Cited by 338 · see citing works

Functional Anatomy of Polycomb and Trithorax Chromatin Landscapes in Drosophila Embryos

Schuettengruber, B., Ganapathi, M., Leblanc, B., Portoso, M., Jaschek, R., Tolhuis, B., van Lohuizen, M., Tanay, A., & Cavalli, G. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000013 · Cited by 331 · see citing works

H3K27 Demethylases, at Long Last

Swigut, T., & Wysocka, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.026 · Cited by 327 · see citing works

ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing

Jacob, Y., Feng, S., LeBlanc, C., Bernatavichute, Y. V., Stroud, H., Cokus, S. J., Johnson, L. M., Pellegrini, M. A., Jacobsen, S. E., & Michaels, S. D. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1611 · Cited by 324 · see citing works

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

Landeira, D., Sauer, S., Poot, R. A., Dvorkina, M., Mazzarella, L., Jørgensen, H. F., Pereira, C., Leleu, M., Piccolo, F. M., Spivakov, M., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2065 · Cited by 319 · see citing works

A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness

Woo, C. J., Kharchenko, P. V., Daheron, L. M., Park, P. J., & Kingston, R. E. (2010) · Cell · doi:10.1016/j.cell.2009.12.022 · Cited by 316 · see citing works

Suz12 binds to silenced regions of the genome in a cell-type-specific mannerPreprint

Squazzo, S. L., O’Geen, H., Komashko, V., Krig, S. R., Jin, V. X., Jang, S.-W., Margueron, R., Reinberg, D., Green, R., & Farnham, P. (2006) · Genome Research · doi:10.1101/gr.5306606 · Cited by 310 · see citing works

Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis

Wang, L., Jin, Q., Lee, J., Su, I.-H., & Ge, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000031107 · Cited by 299 · see citing works

Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity

Endoh, M., Endo, T. A., Endoh, T., Fujimura, Y., Ohara, O., Toyoda, T., Otte, A. P., Okano, M., Brockdorff, N., Vidal, M., et al. (2008) · Development · doi:10.1242/dev.014340 · Cited by 286 · see citing works

Ezh2 Requires PHF1 To Efficiently Catalyze H3 Lysine 27 Trimethylation In Vivo

Sarma, K., Margueron, R., Ivanov, A. V., Pirrotta, V., & Reinberg, D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02017-07 · Cited by 286 · see citing works

Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liverPreprint

Brunner, A. L., Johnson, D. S., Kim, S. W., Valouev, A., Reddy, T. E., Neff, N. F., Anton, E., Medina, C., Nguyen, L., Chiao, E. T., et al. (2009) · Genome Research · doi:10.1101/gr.088773.108 · Cited by 283 · see citing works

Pcl‐PRC2 is needed to generate high levels of H3‐K27 trimethylation at Polycomb target genes

Nekrasov, M., Klymenko, T., Fraterman, S., Papp, B., Oktaba, K., Köcher, T., Cohen, A., Stunnenberg, H. G., Wilm, M. S., & Müller, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601837 · Cited by 280 · see citing works

Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

Chen, D., Bohrer, L. R., Rai, A. N., Pan, Y., Gan, L., Zhou, X., Bagchi, A., Simon, J. A., & Huang, H. (2010) · Nature Cell Biology · doi:10.1038/ncb2116 · Cited by 277 · see citing works

Diversity of Polycomb group complexes in plants: same rules, different players?

Hennig, L., & Derkacheva, M. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.07.002 · Cited by 274 · see citing works

In Vivo Residue-specific Histone Methylation Dynamics*

Zee, B. M., Levin, R. S., Xu, B., Leroy, G., Wingreen, N., & Garcia, B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.063784 · Cited by 262 · see citing works

Determination of enriched histone modifications in non-genic portions of the human genome

Rosenfeld, J., Wang, Z., Schones, D. E., Zhao, K., DeSalle, R., & Zhang, M. Q. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-143 · Cited by 246 · see citing works

A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain

Sing, A., Pannell, D., Karaiskakis, A., Sturgeon, K., Djabali, M., Ellis, J., Lipshitz, H. D., & Cordes, S. P. (2009) · Cell · doi:10.1016/j.cell.2009.08.020 · Cited by 237 · see citing works

2-D Structure of the A Region of Xist RNA and Its Implication for PRC2 Association

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AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2

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Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential

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Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex

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A Brief History of EpigeneticsPreprint

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Epigenetics and cardiovascular disease

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Gene Silencing Triggers Polycomb Repressive Complex 2 Recruitment to CpG Islands Genome Wide

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Chromatin Connections to Pluripotency and Cellular Reprogramming

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Universal DNA methylation age across mammalian tissues

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Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

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Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks

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A Long ncRNA Links Copy Number Variation to a Polycomb/Trithorax Epigenetic Switch in FSHD Muscular Dystrophy

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The roles of histone variants in fine-tuning chromatin organization and function

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Interactions between JARID2 and Noncoding RNAs Regulate PRC2 Recruitment to Chromatin

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Epigenetics and Bacterial InfectionsPreprint

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Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation

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An update on LNCipedia: a database for annotated human lncRNA sequences

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Chromatin repressive complexes in stem cells, development, and cancer

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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

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Every amino acid matters: essential contributions of histone variants to mammalian development and disease

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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The FLC Locus: A Platform for Discoveries in Epigenetics and Adaptation

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Basic biology and therapeutic implications of lncRNA

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Transcriptional and Epigenetic Control of T Helper Cell Specification: Molecular Mechanisms Underlying Commitment and Plasticity

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Role of PRC 2‐associated factors in stem cells and disease

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Polycomb Repressive Complex 2 Structure and Function

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A Structural Perspective on Gene Repression by Polycomb Repressive Complex 2

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Structural and Mechanistic Insights into Polycomb Repressive Complex 2 Regulation in Gene Silencing

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PRC2 activity, recruitment, and silencing: a comparative perspective

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