Cited by 750Genetic diversity and population structureForensic and Genetic ResearchEvolution and Genetic Dynamics

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Genealogical trees, coalescent theory and the analysis of genetic polymorphisms

Rosenberg, Noah A., Nordborg, Magnus·2002·Nature Reviews Genetics

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Abstract

Improvements in genotyping technologies have led to the increased use of genetic polymorphism for inference about population phenomena, such as migration and selection. Such inference presents a challenge, because polymorphism data reflect a unique, complex, non-repeatable evolutionary history. Traditional analysis methods do not take this into account. A stochastic process known as the 'coalescent' presents a coherent statistical framework for analysis of genetic polymorphisms.

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Authors: Rosenberg, N. A., & Nordborg, M.
Affiliations: University of Southern California (US)
Corresponding author: Nordborg, Magnus
ORCID: Rosenberg, Noah A.
Nordborg, Magnus
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2002-05
Volume: 3
Issue: 5
Pages: 380-390
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg795
OpenAlex: W2114058116
Cited by: 750
References: 110
Citations by year: 2026: 6 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 50 · 2021: 24 · 2020: 23 · 2019: 33 · 2018: 60 · 2017: 41 · 2016: 33 · 2015: 31 · 2014: 49 · 2013: 32 · 2012: 33
FWCI: 3.02
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: genealogical trees, coalescent theory, genetic polymorphism, population genetics, migration, natural selection, genotyping, stochastic processes, evolutionary history
MeSH terms: Animals, Genetics, Population, Humans, Pedigree, Polymorphism, Genetic, Recombination, Genetic, Stochastic Processes, Evolution, Molecular

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Genealogical trees, coalescent theory and the analysis of genetic polymorphisms

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