Cited by 1,076Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and AnimalsHealth, Environment, Cognitive Aging

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Candidate-gene approaches for studying complex genetic traits: practical considerations

Tabor, Holly K., Risch, Neil J., Myers, Richard M.·2002·Nature Reviews Genetics

DOI 10.1038/nrg796

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Abstract

Association studies with candidate genes have been widely used for the study of complex diseases. However, this approach has been criticized because of non-replication of results and limits on its ability to include all possible causative genes and polymorphisms. These challenges have led to pessimism about the candidate-gene approach and about the genetic analysis of complex diseases in general. We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation.

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Authors: Tabor, H. K., Risch, N. J., & Myers, R. M.
Affiliations: Stanford Medicine (US)
Kaiser Permanente (US)
Corresponding author: Myers, Richard M.
ORCID: Tabor, Holly K.
Risch, Neil J.
Myers, Richard M.
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2002-05
Volume: 3
Issue: 5
Pages: 391-397
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg796
OpenAlex: W1969673534
Cited by: 1,076
References: 63
Citations by year: 2026: 5 · 2025: 12 · 2024: 26 · 2023: 21 · 2022: 24 · 2021: 28 · 2020: 34 · 2019: 36 · 2018: 37 · 2017: 47 · 2016: 40 · 2015: 57 · 2014: 39 · 2013: 54 · 2012: 53
FWCI: 8.17
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion, public-domain)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords: candidate gene association, complex traits, complex diseases, replication of results, genetic polymorphism, causal genes, epidemiological principles, genetic epidemiology
MeSH terms: Animals, Humans, Reproducibility of Results, Linkage Disequilibrium, Molecular Epidemiology, Multifactorial Inheritance, Polymorphism, Single Nucleotide

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Candidate-gene approaches for studying complex genetic traits: practical considerations

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